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Irish Journal of Medical Science (1971 -)

Erschienen in:

08.04.2018 | Review Article

An animal model of faecal incontinence and sacral neuromodulation

verfasst von: James F. X. Jones

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2018

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Abstract

The pudendal nerves can be injured during traumatic vaginal childbirth and result in faecal incontinence. Some of these incontinent patients benefit from chronic sacral neuromodulation and the mechanism of action of this therapy has been a focus of many studies. In 2008, a rodent model of neuropathic faecal incontinence was introduced and subsequently validated through a series of investigations. This review summarizes the decade-long contribution of Professor Ronan O’Connell to the inception and application of this rodent model of faecal incontinence and sacral neuromodulation.

Carrington EV, Evers J, Grossi U, Dinning PG, Scott SM, O’Connell PR, Jones JF, Knowles CH (2014) A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 26(9):1222–1237CrossRefPubMedCentral

Evers J, Jones JFX, O’Connell PR (2017) Systematic review of animal models used in research of origins and treatments of fecal incontinence. Dis Colon Rectum 60(6):614–626CrossRef

Healy CF, O’Herlihy C, O’Brien C, O’Connell PR, Jones JFX (2008) Experimental models of neuropathic fecal incontinence. Diseases Colon Rectum 51(11):1619–1626CrossRef

Banahan M, Peirce C, Buffini M, O’Herlihy C, O'Connell PR, Jones JF. (2010). Atrophy of the sphincters of continence in an experimental model. Colorectal Disease 12 (7 Online):e153–7

Griffin KM, O’Herlihy C, O’Connell PR, Jones JF (2012) Combined ischemic and neuropathic insult to the anal canal in an animal model of obstetric-related trauma. Dis Colon Rectum 55(1):32–41CrossRefPubMedCentral

Peirce C, Healy CF, O’Herlihy C, O’Connell PR, Jones JF (2009) Reduced somatosensory cortical activation in experimental models of neuropathic fecal incontinence. Dis Colon Rectum 52(8):1417–1422CrossRefPubMedCentral

Buffini M, O’Halloran KD, O’Herlihy C, O’Connell R, Jones JF (2010) Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat. J Anat 217(3):187–195CrossRefPubMedCentral

Healy CF, McMorrow C, O’Herlihy C, O’Connell PR, JFX J (2008) External anal sphincter fatigue is not improved by N-acetylcysteine in an animal model. Neurogastroenterology Motility 20(6):719–724CrossRefPubMedCentral

Peirce C, Alexander LE, O’Herlihy C, O’Connell PR, Jones JF (2010) Central representation of the inferior rectal nerve of the rat. Dis Colon Rectum 53(3):315–320CrossRefPubMedCentral

10.

Buffini M, O’Halloran KD, O’Herlihy C, O’Connell PR, Jones JF (2012) Comparison of the motor discharge to the voluntary sphincters of continence in the rat. Neurogastroenterol Motil 24(4):e175–e184CrossRefPubMedCentral

11.

Soetan BK, O’Connell PR, Jones JF (2014) Behavioural studies of faecal continence in the rat. Ir J Med Sci 183(4):629–632CrossRefPubMedCentral

12.

Devane LA, Lucking E, Evers J, Buffini M, Scott SM, Knowles CH, O’Connell PR, Jones JF Altered defecatory behaviour and faecal incontinence in a video-tracked animal model of pudendal neuropathy. Colorectal Dis 60(6):614–626

13.

Devane LA, Evers J, Scott MS, Knowles CH, O’Connell P, Jones JF (2016) Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model. Neurogastroenterol Motil 28(3):358–363CrossRefPubMedCentral

14.

Peirce C, O’Herlihy C, O’Connell PR, Jones JF (2011) Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence. British J Surgery 98(8):1155–1159CrossRef

15.

Griffin KM, Pickering M, O’Herlihy C, O’Connell PR, Jones JF (2011) Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model. British J Surgery 98(8):1160–1169CrossRef

16.

Griffin KM, Blau CW, Kelly ME, O’Herlihy C, O’Connell PR, Jones JF, Kerskens CM (2010) Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat. NeuroImage 51(4):1395–1404CrossRefPubMedCentral

17.

Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O’Connell PR, Jones JF (2014) Effects of stimulation frequency and intensity in sacral neuromodulation on anorectal inputs to the somatosensory cortex in an experimental model. Br J Surg Sep 101(10):1317–1328CrossRef

18.

Carrington EV, Evers J, Scott SM, Knowles CH, O’Connell PR, Jones JF (2015) Mechanically evoked cortical potentials: a physiological approach to assessment of anorectal sensory pathways. J Neurosci Methods 256:198–202CrossRefPubMedCentral

19.

Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O’Connell PR, Jones JF (2016) Reversal of sensory deficit through sacral neuromodulation in an animal model of fecal incontinence. Neurogastroenterol Motil 28(5):665–673CrossRefPubMedCentral

Titel: An animal model of faecal incontinence and sacral neuromodulation
verfasst von: James F. X. Jones
Publikationsdatum: 08.04.2018
Verlag: Springer London
Erschienen in: Irish Journal of Medical Science (1971 -) / Ausgabe 4/2018
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-018-1805-2

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