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01.10.2010 | Head and Neck

An exploratory pilot study into the association between microcirculatory parameters derived by MRI-based pharmacokinetic analysis and glucose utilization estimated by PET-CT imaging in head and neck cancer

verfasst von: Sotirios Bisdas, Oliver Seitz, Markus Middendorp, Nicole Chambron-Pinho, Theodosios Bisdas, Thomas J. Vogl, Renate Hammerstingl, Ulrike Ernemann, Martin G. Mack

Erschienen in: European Radiology | Ausgabe 10/2010

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Abstract

Objectives:

To examine the feasibility of deriving quantitative microcirculatory parameters and to investigate the relationship between vascular and metabolic characteristics of head and neck tumours in vivo, using dynamic contrast-enhanced (DCE) MRI and fluorodeoxyglucose (FDG) PET imaging.

Methods:

Twenty-seven patients with primary squamous cell carcinoma (SCCA) underwent DCE-MRI and combined PET/CT imaging. DCE-MRI data were post-processed by using commercially available software. Transfer constant (K ^trans), extravascular extracellular blood volume (v _e), transfer constant from the extracellular extravascular space to plasma (k _ep) and iAUC (initial area under the signal intensity–time curve) were calculated. 3D static PET data were acquired and standardised uptake values (SUV) calculated.

Results:

All microcirculatory parameters in tumours were higher than in normal muscle tissue (P ≤ 0.0019). Significant correlations were shown between k _ep and K ^trans (ρ = 0.77), v _e and k _ep (ρ = −0.7), and iAUC and v _e (ρ = 0.53). Significant correlations were observed for SUV_mean and v _e as well as iAUC (ρ = 0.42 and ρ = 0.66, respectively). SUV_max was significantly correlated with iAUC (ρ = 0.69).

Conclusions:

The demonstrated relationships between vascular and metabolic characteristics of primary SCCA imply a complex interaction between vascular delivery characteristics and tumour metabolism. The lack of correlation between SUV and K ^trans/k _ep suggests that both diagnostic techniques may provide complementary information.

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Titel: An exploratory pilot study into the association between microcirculatory parameters derived by MRI-based pharmacokinetic analysis and glucose utilization estimated by PET-CT imaging in head and neck cancer
verfasst von: Sotirios Bisdas
Oliver Seitz
Markus Middendorp
Nicole Chambron-Pinho
Theodosios Bisdas
Thomas J. Vogl
Renate Hammerstingl
Ulrike Ernemann
Martin G. Mack
Publikationsdatum: 01.10.2010
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 10/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1803-x

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An exploratory pilot study into the association between microcirculatory parameters derived by MRI-based pharmacokinetic analysis and glucose utilization estimated by PET-CT imaging in head and neck cancer

Abstract

Objectives:

Methods:

Results:

Conclusions:

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