01.12.2017 | Research article | Ausgabe 1/2017 Open Access

An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Background
Methods
Study population
Physical functioning
Physical activity
Covariates
Statistical analyses
Results
Participant characteristics
Total
|
Recovery of physical functioning
|
||
---|---|---|---|
Yes
|
No
|
||
46%
|
54%
|
||
(
n = 327)
|
(
n = 149)
|
(
n = 178)
|
|
Socio-demographic characteristics
a
|
|||
Age (y)
b
|
65 ± 10
|
66 ± 9
|
65 ± 10
|
Male
|
198 (61%)
|
87 (58%)
|
111 (62%)
|
Education level
|
|||
Low
|
155 (47%)
|
69 (46%)
|
86 (48%)
|
Middle
|
66 (20%)
|
31 (21%)
|
35 (20%)
|
High
|
106 (32%)
|
49 (33%)
|
57 (32%)
|
Living with partner
|
263 (80%)
|
119 (80%)
|
144 (81%)
|
Lifestyle characteristics
|
|||
Smoking status
|
|||
Never
|
99 (30%)
|
50 (34%)
|
49 (28%)
|
Former
|
188 (58%)
|
85 (58%)
|
103 (58%)
|
Current smoker before surgery
|
38 (12%)
|
12 (8%)
|
26 (15%)
|
Body mass index before surgery (kg/m
2)
|
|||
< 20
|
13 (4%)
|
9 (6%)
|
4 (2%)
|
≥ 20–25
|
134 (41%)
|
63 (42%)
|
71 (40%)
|
≥ 25–30
|
141 (43%)
|
68 (46%)
|
73 (41%)
|
≥ 30
|
39 (12%)
|
9 (6%)
|
30 (17%)
|
≥ 150 min/week physical activity before surgery
|
281 (86%)
|
126 (85%)
|
155 (87%)
|
Physical activity before surgery (h/week)
|
9.0 (4.5–17.8)
|
8.5 (4.0–17.8)
|
9.8 (4.9–17.3)
|
Physical activity at six months post-diagnosis (h/week)
|
6.0 (2.0–11.5)
|
8.0 (4.0–14.1)
|
4.1 (0.8–8.3)
|
Physical activity difference (h/week)
|
−2.5 (-8.0–0.7)
|
−1.0 (-5.0–3.0)
|
−4.0 (-12.0--0.3)
|
Increase of ≥60 min/week of physical activity
|
81 (25%)
|
55 (37%)
|
26 (15%)
|
Clinical characteristics
|
|||
Colon cancer
|
233 (71%)
|
116 (78%)
|
117 (66%)
|
Rectal cancer
|
92 (28%)
|
32 (21%)
|
60 (34%)
|
Disease stage (pTNM)
|
|||
Stage I
|
96 (29%)
|
41 (28%)
|
55 (31%)
|
Stage II
|
112 (34%)
|
70 (47%)
|
42 (24%)
|
Stage III
|
119 (36%)
|
38 (26%)
|
81 (46%)
|
Neo-adjuvant therapy
|
73 (22%)
|
25 (17%)
|
48 (27%)
|
Adjuvant chemotherapy
|
91 (28%)
|
28 (19%)
|
63 (35%)
|
Ostomy
|
103 (32%)
|
35 (23%)
|
68 (38%)
|
Ostomy reversal
|
32 (10%)
|
14 (9%)
|
18 (10%)
|
Length of hospital stay > 10 days
|
82 (25%)
|
35 (23%)
|
47 (27%)
|
Days after surgery
b
|
164 ± 25
|
167 ± 24
|
162 ± 25
|
Health status characteristics
|
|||
Comorbidity before surgery
c
|
142 (43%)
|
57 (40%)
|
85 (60%)
|
Physical functioning before surgery
|
93.3 (86.7–100)
|
93.3 (80.0–100)
|
93.3 (86.7–100)
|
Physical functioning at six months post-diagnosis
|
86.7 (73.3–93.3)
|
93.3 (86.7–100)
|
73.3 (60.0–86.7)
|
Change in physical functioning
|
−6.7 (-13.3–0.0)
|
0.0 (0.0–6.7)
|
−13.3 (-26.7--6.7)
|
Increase in physical activity after surgery
Moderate-to-vigorous activity level
|
No. events/ at risk
|
Adjusted PR (95% CI)
|
Adjusted PR (95% CI)
|
---|---|---|---|
Stable activity
|
25/42
|
1.00
|
|
Inactive
a with stable activity
|
12/20
|
1.00
|
|
Active
b with stable activity
|
13/22
|
0.91 (0.65–1.26)
|
|
Increased activity
|
26/81
|
0.57 (0.39–0.82)
|
|
Inactive with increasing activity
|
6/19
|
0.53 (0.29–0.97)
|
|
Active with increasing activity
|
20/62
|
0.55 (0.39–0.78)
|