Skip to main content
Erschienen in: Pediatric Cardiology 6/2016

09.05.2016 | Original Article

An Observation from Liver Biopsies Two Decades Post-Fontan

verfasst von: William N. Evans, Ruben J. Acherman, Leigh C. Reardon, Alvaro Galindo, Abraham Rothman, Michael L. Ciccolo, Sergio A. Carrillo, Brody J. Winn, Noel S. Yumiaco, Humberto Restrepo

Erschienen in: Pediatric Cardiology | Ausgabe 6/2016

Einloggen, um Zugang zu erhalten

Abstract

This brief report describes an observation from liver biopsy results in nonfailing Fontan patients, currently in their second postoperative decade. In three patients, with either atriopulmonary or atrioventricular connections and functional left ventricles, we found no portal fibrosis. In contrast, we found portal fibrosis in three clinically similar, nonfailing Fontan patients with lateral tunnel connections and functional left ventricles. We recognize the results may be secondary to chance; nevertheless, we speculate about possible relevancy.
Literatur
1.
Zurück zum Zitat Bjork VO, Olin CL, Bjarke BB, Thoren CA (1979) Right atrial-right ventricular anastomosis for correction of tricuspid atresia. J Thorac Cardiovasc Surg 77:452–458PubMed Bjork VO, Olin CL, Bjarke BB, Thoren CA (1979) Right atrial-right ventricular anastomosis for correction of tricuspid atresia. J Thorac Cardiovasc Surg 77:452–458PubMed
2.
Zurück zum Zitat Kreutzer GO, Vargas FJ, Schlichter AJ, Laura JP, Suarez JC, Coronel AR, Kreutzer EA (1982) Atriopulmonary anastomosis. J Thorac Cardiovasc Surg 83:427–436PubMed Kreutzer GO, Vargas FJ, Schlichter AJ, Laura JP, Suarez JC, Coronel AR, Kreutzer EA (1982) Atriopulmonary anastomosis. J Thorac Cardiovasc Surg 83:427–436PubMed
3.
Zurück zum Zitat Puga FJ, Chiavarelli M, Hagler DJ (1987) Modification of the Fontan operation applicable to patients with left atrioventricular valve atresia or single atrioventricular valve. Circulation 76(suppl III):III-53–III-60 Puga FJ, Chiavarelli M, Hagler DJ (1987) Modification of the Fontan operation applicable to patients with left atrioventricular valve atresia or single atrioventricular valve. Circulation 76(suppl III):III-53–III-60
4.
Zurück zum Zitat De Leval MR, Kilner P, Gewillig M, Bull C (1988) Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. J Thorac Cardiovasc Surg 96:682–695PubMed De Leval MR, Kilner P, Gewillig M, Bull C (1988) Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. J Thorac Cardiovasc Surg 96:682–695PubMed
5.
Zurück zum Zitat Marcelletti C, Corno A, Giannico S, Marino B (1990) Inferior vena cava-pulmonary artery extracardiac conduit. A new form of right heart bypass. J Thorac Cardiovasc Surg 100:228–232PubMed Marcelletti C, Corno A, Giannico S, Marino B (1990) Inferior vena cava-pulmonary artery extracardiac conduit. A new form of right heart bypass. J Thorac Cardiovasc Surg 100:228–232PubMed
6.
Zurück zum Zitat Evans WN, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Acherman RJ, Restrepo H (2014) Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization. Pediatr Cardiol 35:1273–1278CrossRefPubMed Evans WN, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Acherman RJ, Restrepo H (2014) Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization. Pediatr Cardiol 35:1273–1278CrossRefPubMed
7.
Zurück zum Zitat Evans WN, Acherman RJ, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Restrepo H (2015) Fontan hepatic fibrosis and pulmonary vascular development. Pediatr Cardiol 36:657–661CrossRefPubMed Evans WN, Acherman RJ, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Restrepo H (2015) Fontan hepatic fibrosis and pulmonary vascular development. Pediatr Cardiol 36:657–661CrossRefPubMed
8.
Zurück zum Zitat Evans WN, Acherman RJ, Reardon LC, Ciccolo ML, Galindo A, Rothman A, Winn BJ, Yumiaco NS, Restrepo H (2016) Fontan outcomes and pulmonary blood flow at birth. Pediatr Cardiol 37:30–36CrossRefPubMed Evans WN, Acherman RJ, Reardon LC, Ciccolo ML, Galindo A, Rothman A, Winn BJ, Yumiaco NS, Restrepo H (2016) Fontan outcomes and pulmonary blood flow at birth. Pediatr Cardiol 37:30–36CrossRefPubMed
9.
Zurück zum Zitat Wu FM, Jonas MM, Opotowsky AR, Harmon A, Raza R, Ukomadu C, Landzberg MJ, Singh MN, Valente AM, Egidy Assenza G, Perez-Atayde AR (2015) Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes. J Heart Lung Transplant 34:883–891CrossRefPubMed Wu FM, Jonas MM, Opotowsky AR, Harmon A, Raza R, Ukomadu C, Landzberg MJ, Singh MN, Valente AM, Egidy Assenza G, Perez-Atayde AR (2015) Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes. J Heart Lung Transplant 34:883–891CrossRefPubMed
10.
Zurück zum Zitat Kiesewetter CH, Sheron N, Vettukattill JJ, Hacking N, Stedman B, Millward-Sadler H, Haw M, Cope R, Salmon AP, Sivaprakasam MC, Kendall T, Keeton BR, Iredale JP, Veldtman GR (2007) Hepatic changes in the failing Fontan circulation. Heart 93:579–584CrossRefPubMed Kiesewetter CH, Sheron N, Vettukattill JJ, Hacking N, Stedman B, Millward-Sadler H, Haw M, Cope R, Salmon AP, Sivaprakasam MC, Kendall T, Keeton BR, Iredale JP, Veldtman GR (2007) Hepatic changes in the failing Fontan circulation. Heart 93:579–584CrossRefPubMed
11.
Zurück zum Zitat Kendall TJ, Stedman B, Hacking N, Haw M, Vettukattill JJ, Salmon AP, Cope R, Sheron N, Millward-Sadler H, Veldtman GR, Iredale JP (2008) Hepatic fibrosis and cirrhosis in the Fontan circulation: a detailed morphological study. J Clin Pathol 61:504–508CrossRefPubMed Kendall TJ, Stedman B, Hacking N, Haw M, Vettukattill JJ, Salmon AP, Cope R, Sheron N, Millward-Sadler H, Veldtman GR, Iredale JP (2008) Hepatic fibrosis and cirrhosis in the Fontan circulation: a detailed morphological study. J Clin Pathol 61:504–508CrossRefPubMed
12.
Zurück zum Zitat Schwartz MC, Sullivan L, Cohen MS, Russo P, John AS, Guo R, Guttenberg M, Rand EB (2012) Hepatic pathology may develop before the Fontan operation in children with functional single ventricle: an autopsy study. J Thorac Cardiovasc Surg 143:904–909CrossRefPubMed Schwartz MC, Sullivan L, Cohen MS, Russo P, John AS, Guo R, Guttenberg M, Rand EB (2012) Hepatic pathology may develop before the Fontan operation in children with functional single ventricle: an autopsy study. J Thorac Cardiovasc Surg 143:904–909CrossRefPubMed
13.
Zurück zum Zitat Johnson JA, Cetta F, Graham RP, Smyrk TC, Driscoll DJ, Phillips SD, John AS (2013) Identifying predictors of hepatic disease in patients after the Fontan operation: a postmortem analysis. J Thorac Cardiovasc Surg 146:140–145CrossRefPubMed Johnson JA, Cetta F, Graham RP, Smyrk TC, Driscoll DJ, Phillips SD, John AS (2013) Identifying predictors of hepatic disease in patients after the Fontan operation: a postmortem analysis. J Thorac Cardiovasc Surg 146:140–145CrossRefPubMed
14.
Zurück zum Zitat Schwartz MC, Sullivan LM, Glatz AC, Rand E, Russo P, Goldberg DJ, Rome JJ, Cohen MS (2013) Portal and sinusoidal fibrosis are common on liver biopsy after Fontan surgery. Pediatr Cardiol 34:135–142CrossRefPubMed Schwartz MC, Sullivan LM, Glatz AC, Rand E, Russo P, Goldberg DJ, Rome JJ, Cohen MS (2013) Portal and sinusoidal fibrosis are common on liver biopsy after Fontan surgery. Pediatr Cardiol 34:135–142CrossRefPubMed
15.
Zurück zum Zitat Bronicki RA (2014) Cardiopulmonary interactions. In: Wheeler DS, Wong HR, Shanley TP (eds) Pediatric critical care medicine, volume 2, respiratory cardiovascular and central nervous systems. Springer, London, p 324 Bronicki RA (2014) Cardiopulmonary interactions. In: Wheeler DS, Wong HR, Shanley TP (eds) Pediatric critical care medicine, volume 2, respiratory cardiovascular and central nervous systems. Springer, London, p 324
16.
Zurück zum Zitat Honda T, Itatani K, Takanashi M, Mineo E, Kitagawa A, Ando H, Kimura S, Nakahata Y, Oka N, Miyaji K, Ishii M (2014) Quantitative evaluation of hemodynamics in the Fontan circulation: a cross-sectional study measuring energy loss in vivo. Pediatr Cardiol 35:361–367CrossRefPubMed Honda T, Itatani K, Takanashi M, Mineo E, Kitagawa A, Ando H, Kimura S, Nakahata Y, Oka N, Miyaji K, Ishii M (2014) Quantitative evaluation of hemodynamics in the Fontan circulation: a cross-sectional study measuring energy loss in vivo. Pediatr Cardiol 35:361–367CrossRefPubMed
17.
Zurück zum Zitat Quinton E, Nightingale P, Hudsmith L, Thorne S, Marshall H, Clift P, de Bono J (2015) Prevalence of atrial tachyarrhythmia in adults after Fontan operation. Heart 101:1672–1677CrossRefPubMed Quinton E, Nightingale P, Hudsmith L, Thorne S, Marshall H, Clift P, de Bono J (2015) Prevalence of atrial tachyarrhythmia in adults after Fontan operation. Heart 101:1672–1677CrossRefPubMed
18.
Zurück zum Zitat Schwartz MC, Glatz AC, Daniels K, Goldberg DJ, Rand E, Epelman MS, Cohen MS (2015) Hepatic Abnormalities Are Present Before and Early After the Fontan Operation. Ann Thorac Surg 100:2298–2304CrossRefPubMed Schwartz MC, Glatz AC, Daniels K, Goldberg DJ, Rand E, Epelman MS, Cohen MS (2015) Hepatic Abnormalities Are Present Before and Early After the Fontan Operation. Ann Thorac Surg 100:2298–2304CrossRefPubMed
19.
Zurück zum Zitat Chopski SG, Fox CS, Riddle ML, McKenna KL, Patel JP, Rozolis JT, Throckmorton AL (2015) Pressure-flow experimental performance of new intravascular blood pump designs for Fontan patients. Artif Organs. doi:10.1111/aor.12549 Chopski SG, Fox CS, Riddle ML, McKenna KL, Patel JP, Rozolis JT, Throckmorton AL (2015) Pressure-flow experimental performance of new intravascular blood pump designs for Fontan patients. Artif Organs. doi:10.​1111/​aor.​12549
Metadaten
Titel
An Observation from Liver Biopsies Two Decades Post-Fontan
verfasst von
William N. Evans
Ruben J. Acherman
Leigh C. Reardon
Alvaro Galindo
Abraham Rothman
Michael L. Ciccolo
Sergio A. Carrillo
Brody J. Winn
Noel S. Yumiaco
Humberto Restrepo
Publikationsdatum
09.05.2016
Verlag
Springer US
Erschienen in
Pediatric Cardiology / Ausgabe 6/2016
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-016-1403-x

Weitere Artikel der Ausgabe 6/2016

Pediatric Cardiology 6/2016 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.