Skip to main content
Erschienen in: European Radiology 2/2018

07.09.2017 | Musculoskeletal

An open-label, prospective, observational study of the efficacy of bisphosphonate therapy for painful osteoid osteoma

verfasst von: Valérie Bousson, Tifenn Leturcq, Hang-Korng Ea, Olivier Hauger, Nadia Mehsen-Cetre, Bassam Hamzé, Caroline Parlier-Cuau, Jean-Denis Laredo, Thierry Schaeverbeke, Philippe Orcel

Erschienen in: European Radiology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To assess the efficacy of bisphosphonate therapy on bone pain in patients with osteoid osteoma (OO) (main objective), and to describe bisphosphonate-induced changes in nidus mineralisation and regional bone-marrow oedema (BMO).

Methods

A prospective, observational study was conducted from 2011 to 2014. Patients with risk factors for complications of percutaneous or surgical ablation or recurrence after ablation, were offered once monthly intravenous bisphosphonate treatment until significant pain alleviation was achieved.

Results

We included 23 patients. The first two patients received pamidronate and the next 21 zoledronic acid (mean, 2.95 infusions per patient). Bisphosphonate therapy was successful in 19 patients (83%), whose mean pain visual analogue scale score decreased by 76.7%; this pain-relieving effect persisted in 17 patients (74%) with a mean follow-up time of 36 months. Computed tomography (CT) demonstrated a mean nidus density increase of 177.7% (p = 0.001). By magnetic resonance imaging (MRI), mean decreases were 38.4% for BMO surface area and 30.3% for signal intensity (p = 0.001 and p = 0.000, respectively).

Conclusions

In 17/23 patients with painful OO managed conservatively with bisphosphonates, long-term final success was achieved. Bisphosphonates may accelerate the spontaneous healing of OO.

Key points

19/23 patients with OO managed with bisphosphonates experienced significant pain relief
Pain relief was sustained in 17/23 patients, mean follow-up of 36 months
CT demonstrated a significant increase in nidus mineralisation
MRI demonstrated a significant decrease in bone marrow oedema
Bisphosphonate therapy may accelerate the spontaneous healing of OO
Literatur
1.
Zurück zum Zitat Jaffe H (1935) “Osteoid osteoma”. A benign osteoblastic tumor composed of osteoid and atypical bone. Arch Surg 31:709–728CrossRef Jaffe H (1935) “Osteoid osteoma”. A benign osteoblastic tumor composed of osteoid and atypical bone. Arch Surg 31:709–728CrossRef
2.
Zurück zum Zitat Klein MH, Shankman S (1992) Osteoid osteoma: radiologic and pathologic correlation. Skelet Radiol 21:23–31CrossRef Klein MH, Shankman S (1992) Osteoid osteoma: radiologic and pathologic correlation. Skelet Radiol 21:23–31CrossRef
4.
Zurück zum Zitat Gangi A, Alizadeh H, Wong L, Buy X, Dietemann J-L, Roy C (2007) Osteoid osteoma: percutaneous laser ablation and follow-up in 114 patients. Radiology 242:293–301CrossRefPubMed Gangi A, Alizadeh H, Wong L, Buy X, Dietemann J-L, Roy C (2007) Osteoid osteoma: percutaneous laser ablation and follow-up in 114 patients. Radiology 242:293–301CrossRefPubMed
5.
Zurück zum Zitat Rybak LD, Gangi A, Buy X, La Rocca Vieira R, Wittig J (2010) Thermal ablation of spinal osteoid osteomas close to neural elements: technical considerations. AJR Am J Roentgenol 195:293–298CrossRef Rybak LD, Gangi A, Buy X, La Rocca Vieira R, Wittig J (2010) Thermal ablation of spinal osteoid osteomas close to neural elements: technical considerations. AJR Am J Roentgenol 195:293–298CrossRef
6.
Zurück zum Zitat Boonekamp PM, van der Wee-Pals LJ, van Wijk-van Lennep MM, Thesing CW, Bijvoet OL (1986) Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1:27–39PubMed Boonekamp PM, van der Wee-Pals LJ, van Wijk-van Lennep MM, Thesing CW, Bijvoet OL (1986) Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1:27–39PubMed
8.
Zurück zum Zitat Arzoo K, Sadeghi S, Pullarkat V (2001) Pamidronate for bone pain from osteolytic lesions in Langerhans’-cell histiocytosis. N Engl J Med 345:225CrossRefPubMed Arzoo K, Sadeghi S, Pullarkat V (2001) Pamidronate for bone pain from osteolytic lesions in Langerhans’-cell histiocytosis. N Engl J Med 345:225CrossRefPubMed
9.
Zurück zum Zitat Chapurlat RD, Delmas PD, Liens D, Meunier PJ (1997) Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. J Bone Miner Res 12:1746–1752CrossRefPubMed Chapurlat RD, Delmas PD, Liens D, Meunier PJ (1997) Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. J Bone Miner Res 12:1746–1752CrossRefPubMed
10.
Zurück zum Zitat Cornelis F, Truchetet ME, Amoretti N et al (2014) Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy. Bone 58:11–16CrossRefPubMed Cornelis F, Truchetet ME, Amoretti N et al (2014) Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy. Bone 58:11–16CrossRefPubMed
11.
Zurück zum Zitat Vickers C, Pugh D, Ivins J (1959) Osteoid osteoma. A fifteen-year follow-up of an untreated patient. J Bone Jt Surg 41:357–358CrossRef Vickers C, Pugh D, Ivins J (1959) Osteoid osteoma. A fifteen-year follow-up of an untreated patient. J Bone Jt Surg 41:357–358CrossRef
13.
Zurück zum Zitat Högler W, Yap F, Little D, Ambler G, McQuade M, Cowell CT (2004) Short-term safety assessment in the use of intravenous zoledronic acid in children. J Pediatr 145:701–704CrossRefPubMed Högler W, Yap F, Little D, Ambler G, McQuade M, Cowell CT (2004) Short-term safety assessment in the use of intravenous zoledronic acid in children. J Pediatr 145:701–704CrossRefPubMed
14.
Zurück zum Zitat Munns CF, Rajab MH, Hong J et al (2007) Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone 41:366–370CrossRefPubMed Munns CF, Rajab MH, Hong J et al (2007) Acute phase response and mineral status following low dose intravenous zoledronic acid in children. Bone 41:366–370CrossRefPubMed
15.
Zurück zum Zitat Brown JJ, Zacharin MR (2009) Safety and efficacy of intravenous zoledronic acid in paediatric osteoporosis. J Pediatr Endocrinol Metab 22:55–63CrossRefPubMed Brown JJ, Zacharin MR (2009) Safety and efficacy of intravenous zoledronic acid in paediatric osteoporosis. J Pediatr Endocrinol Metab 22:55–63CrossRefPubMed
16.
Zurück zum Zitat de Berg JC, Pattynama PM, Obermann WR, Bode PJ, Vielvoye GJ, Taminiau AH (1995) Percutaneous computed-tomography-guided thermocoagulation for osteoid osteomas. Lancet 346:350–351CrossRefPubMed de Berg JC, Pattynama PM, Obermann WR, Bode PJ, Vielvoye GJ, Taminiau AH (1995) Percutaneous computed-tomography-guided thermocoagulation for osteoid osteomas. Lancet 346:350–351CrossRefPubMed
17.
Zurück zum Zitat Goto T, Shinoda Y, Okuma T et al (2011) Administration of nonsteroidal anti-inflammatory drugs accelerates spontaneous healing of osteoid osteoma. Arch Orthop Trauma Surg 131:619–625CrossRefPubMed Goto T, Shinoda Y, Okuma T et al (2011) Administration of nonsteroidal anti-inflammatory drugs accelerates spontaneous healing of osteoid osteoma. Arch Orthop Trauma Surg 131:619–625CrossRefPubMed
18.
Zurück zum Zitat Kneisl JS, Simon MA (1992) Medical management compared with operative treatment for osteoid-osteoma. J Bone Joint Surg Am 74:179–185CrossRefPubMed Kneisl JS, Simon MA (1992) Medical management compared with operative treatment for osteoid-osteoma. J Bone Joint Surg Am 74:179–185CrossRefPubMed
19.
Zurück zum Zitat Yanagawa T, Watanabe H, Shinozaki T, Ahmed AR, Shirakura K, Takagishi K (2001) The natural history of disappearing bone tumours and tumour-like conditions. Clin Radiol 56:877–886CrossRefPubMed Yanagawa T, Watanabe H, Shinozaki T, Ahmed AR, Shirakura K, Takagishi K (2001) The natural history of disappearing bone tumours and tumour-like conditions. Clin Radiol 56:877–886CrossRefPubMed
20.
Zurück zum Zitat Ilyas I, Younge DA Medical management of osteoid osteoma. Can J Surg 45:435–437 Ilyas I, Younge DA Medical management of osteoid osteoma. Can J Surg 45:435–437
21.
Zurück zum Zitat Coulier B, Mailleux P, Munting E (2005) Spontaneous remission of an osteoid osteoma of the axis. JBR-BTR 88:43PubMed Coulier B, Mailleux P, Munting E (2005) Spontaneous remission of an osteoid osteoma of the axis. JBR-BTR 88:43PubMed
22.
Zurück zum Zitat Jayakumar P, Harish S, Nnadi C, Noordeen H, Saifuddin A (2007) Symptomatic resolution of spinal osteoid osteoma with conservative management: imaging correlation. Skelet Radiol 36:S72–S76CrossRef Jayakumar P, Harish S, Nnadi C, Noordeen H, Saifuddin A (2007) Symptomatic resolution of spinal osteoid osteoma with conservative management: imaging correlation. Skelet Radiol 36:S72–S76CrossRef
23.
Zurück zum Zitat Aiba H, Hayashi K, Inatani H et al (2014) Conservative treatment for patients with osteoid osteoma: a case series. Anticancer Res 34:3721–3725PubMed Aiba H, Hayashi K, Inatani H et al (2014) Conservative treatment for patients with osteoid osteoma: a case series. Anticancer Res 34:3721–3725PubMed
24.
Zurück zum Zitat Yokouchi M, Nagano S, Shimada H et al (2014) Early complete remission of osteoid osteoma with conservative medical management. Pediatr Rep 6:5311CrossRefPubMedPubMedCentral Yokouchi M, Nagano S, Shimada H et al (2014) Early complete remission of osteoid osteoma with conservative medical management. Pediatr Rep 6:5311CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Touraine S, Emerich L, Bisseret D, Genah I, Parlier-Cuau C, Hamze B, Petrover D, Laredo JD, Bousson V (2014) Is pain duration associated with morphologic changes of osteoid osteomas at CT? Radiology 271(3):795–804. doi:10.1148/radiol.14131629 Touraine S, Emerich L, Bisseret D, Genah I, Parlier-Cuau C, Hamze B, Petrover D, Laredo JD, Bousson V (2014) Is pain duration associated with morphologic changes of osteoid osteomas at CT? Radiology 271(3):795–804. doi:10.​1148/​radiol.​14131629
26.
Zurück zum Zitat Fuchs S, Gebauer B, Stelter L et al (2014) Postinterventional MRI findings following MRI-guided laser ablation of osteoid osteoma. Eur J Radiol 83:696–702CrossRefPubMed Fuchs S, Gebauer B, Stelter L et al (2014) Postinterventional MRI findings following MRI-guided laser ablation of osteoid osteoma. Eur J Radiol 83:696–702CrossRefPubMed
27.
Zurück zum Zitat de Chadarévian J-P, Katsetos CD, Pascasio JM, Geller E, Herman MJ (2007) Histological study of osteoid osteoma’s blood supply. Pediatr Dev Pathol 10:358–368CrossRefPubMed de Chadarévian J-P, Katsetos CD, Pascasio JM, Geller E, Herman MJ (2007) Histological study of osteoid osteoma’s blood supply. Pediatr Dev Pathol 10:358–368CrossRefPubMed
28.
Zurück zum Zitat Klein MJ, Parisien MV, Schneider-Stock R (2002) Osteoid osteoma. In: Fletcher CDM, Unni KK, Mertens F (eds) Pathology and genetics—tumors of soft tissue and bone. IARC Press, Lyon, pp 260–261 Klein MJ, Parisien MV, Schneider-Stock R (2002) Osteoid osteoma. In: Fletcher CDM, Unni KK, Mertens F (eds) Pathology and genetics—tumors of soft tissue and bone. IARC Press, Lyon, pp 260–261
29.
Zurück zum Zitat Wood J, Bonjean K, Ruetz S et al (2002) Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 302:1055–1061CrossRefPubMed Wood J, Bonjean K, Ruetz S et al (2002) Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 302:1055–1061CrossRefPubMed
30.
Zurück zum Zitat Igarashi K, Hirafuji M, Adachi H, Shinoda H, Mitani H (1997) Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1. Prostaglandins Leukot Essent Fat Acids 56:121–125CrossRef Igarashi K, Hirafuji M, Adachi H, Shinoda H, Mitani H (1997) Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1. Prostaglandins Leukot Essent Fat Acids 56:121–125CrossRef
31.
Zurück zum Zitat Mungo DV, Zhang X, O’Keefe RJ, Rosier RN, Puzas JE, Schwarz EM (2002) COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res 20:159–162CrossRefPubMed Mungo DV, Zhang X, O’Keefe RJ, Rosier RN, Puzas JE, Schwarz EM (2002) COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res 20:159–162CrossRefPubMed
Metadaten
Titel
An open-label, prospective, observational study of the efficacy of bisphosphonate therapy for painful osteoid osteoma
verfasst von
Valérie Bousson
Tifenn Leturcq
Hang-Korng Ea
Olivier Hauger
Nadia Mehsen-Cetre
Bassam Hamzé
Caroline Parlier-Cuau
Jean-Denis Laredo
Thierry Schaeverbeke
Philippe Orcel
Publikationsdatum
07.09.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5019-1

Weitere Artikel der Ausgabe 2/2018

European Radiology 2/2018 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.