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Erschienen in: The Journal of Obstetrics and Gynecology of India 1/2016

14.06.2016 | Original Article

An Overview on Fertility Outcome in Renal Transplant Recipients

verfasst von: Vineet V. Mishra, Sakshi S. Nanda, Kavita Mistry, Sumesh Choudhary, Rohina Aggarwal, Bhumika M. Vyas

Erschienen in: The Journal of Obstetrics and Gynecology of India | Sonderheft 1/2016

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Abstract

Background

The number of patients undergoing renal transplant are increasing with time. Most of these patients fall in the reproductive age group, who are going to conceive sooner or later. But there are few recipients who either are infertile before transplant or became infertile due to underlying renal pathology responsible for transplantation.

Objective

To study fertility outcome in female renal transplant recipients.

Materials and Methods

Study design: This is a retrospective study conducted at tertiary health center in Ahmedabad, from 2004 to 2014. Inclusion criteria: Renal transplant recipients in the reproductive age group (20–40 years of age) were followed up in gynecology outdoor patient department. Sample size: There were 211 female renal transplant recipients, out of which 113 (53.5 %) patients had complete family, 3 (1.41 %) patients were infertile, 16 (7.58 %) patients have conceived, 33 (15.63 %) patients were lost to follow-up and remaining 46 (21.8 %) did not try for pregnancy. Exclusion criteria: Unmarried patients, divorced and widow patients were excluded.

Results

Out of 19 patients, 16 patients conceived and 3 were infertile. The main cause of infertility in these patients was ovarian factor in 2 patients and tubal factor in 1 patient. Among 16 patients, 8 patients had missed abortion, 2 patients had preterm deliveries and 6 patients had term deliveries.

Conclusion

Peritransplant and preconceptional counseling plays an important role for renal transplant recipients to help them understand the effect of renal pathology and transplantation on their fertility. They can have good fertility and pregnancy outcome with optimum functioning graft.
Literatur
1.
Zurück zum Zitat Anantharaman P, Schmidt RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis. 2007;14:119–25.CrossRefPubMed Anantharaman P, Schmidt RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis. 2007;14:119–25.CrossRefPubMed
2.
Zurück zum Zitat Raiz L, Davies EA, Ferguson RM. Sexual functioning following renal transplantation. Health Soc Work. 2003;28:264–72.CrossRefPubMed Raiz L, Davies EA, Ferguson RM. Sexual functioning following renal transplantation. Health Soc Work. 2003;28:264–72.CrossRefPubMed
3.
Zurück zum Zitat Fischer MJ, Lehnerz SD, Hebert JR, et al. Kidney disease is an independent risk factor for adverse fetal and maternal outcomes in pregnancy. Am J Kidney Dis. 2004;43:415–23.CrossRefPubMed Fischer MJ, Lehnerz SD, Hebert JR, et al. Kidney disease is an independent risk factor for adverse fetal and maternal outcomes in pregnancy. Am J Kidney Dis. 2004;43:415–23.CrossRefPubMed
4.
Zurück zum Zitat Saha MT, Saha HH, Niskanen LK, et al. Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron. 2002;92:735–7.CrossRefPubMed Saha MT, Saha HH, Niskanen LK, et al. Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron. 2002;92:735–7.CrossRefPubMed
5.
Zurück zum Zitat Rathi M, Ramachandran R. Sexual and gonadal dysfunction in chronic kidney disease: pathophysiology. Indian J Endocrinol Metab. 2012;16(2):214–9.CrossRefPubMedPubMedCentral Rathi M, Ramachandran R. Sexual and gonadal dysfunction in chronic kidney disease: pathophysiology. Indian J Endocrinol Metab. 2012;16(2):214–9.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Holley JL, Schmidt RJ, Bender FH, et al. Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis. 1997;29:685–90.CrossRefPubMed Holley JL, Schmidt RJ, Bender FH, et al. Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis. 1997;29:685–90.CrossRefPubMed
7.
Zurück zum Zitat McKay D, Josephson M. Reproduction and transplantation: report on the AST consensus conference on reproductive issues and transplantation. Am J Transplant. 2005;5:1–8.CrossRef McKay D, Josephson M. Reproduction and transplantation: report on the AST consensus conference on reproductive issues and transplantation. Am J Transplant. 2005;5:1–8.CrossRef
8.
Zurück zum Zitat Pezeshki M, Taherian AA, Gharavy M, et al. Menstrual characteristics and pregnancy in women after renal transplantation. Int J Gynaecol Obstet. 2004;85(2):119–25.CrossRefPubMed Pezeshki M, Taherian AA, Gharavy M, et al. Menstrual characteristics and pregnancy in women after renal transplantation. Int J Gynaecol Obstet. 2004;85(2):119–25.CrossRefPubMed
9.
Zurück zum Zitat Lessan-Pezeshki M. Pregnancy after renal transplantation: points to consider. Nephrol Dial Transplant. 2002;17:703–7.CrossRefPubMed Lessan-Pezeshki M. Pregnancy after renal transplantation: points to consider. Nephrol Dial Transplant. 2002;17:703–7.CrossRefPubMed
10.
Zurück zum Zitat Leroy C, Rigot J-M, Leroy M, et al. Immunosuppressive drugs and fertility Orphanet. J Rare Dis. 2015;10:136.CrossRef Leroy C, Rigot J-M, Leroy M, et al. Immunosuppressive drugs and fertility Orphanet. J Rare Dis. 2015;10:136.CrossRef
11.
Zurück zum Zitat Josephson MA, McKay DB. Considerations in the medical management of pregnancy in transplant recipients. Adv Chronic Kidney Dis. 2007;14:156–67.CrossRefPubMed Josephson MA, McKay DB. Considerations in the medical management of pregnancy in transplant recipients. Adv Chronic Kidney Dis. 2007;14:156–67.CrossRefPubMed
12.
Zurück zum Zitat Yildirim Y, Uslu A. Pregnancy in patients with previous successful renal transplantation. Int J Gynaecol Obstet. 2005;90(3):198–202.CrossRefPubMed Yildirim Y, Uslu A. Pregnancy in patients with previous successful renal transplantation. Int J Gynaecol Obstet. 2005;90(3):198–202.CrossRefPubMed
13.
Zurück zum Zitat Tamaki M, Ami M, Kimata N, et al. Successful singleton pregnancy outcome resulting from in vitro fertilization after renal transplantation. Transplantation. 2003;75:1082–3.CrossRefPubMed Tamaki M, Ami M, Kimata N, et al. Successful singleton pregnancy outcome resulting from in vitro fertilization after renal transplantation. Transplantation. 2003;75:1082–3.CrossRefPubMed
14.
Zurück zum Zitat Nouri K, Bader Y, Helmy S, et al. Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J Assist Reprod Genet. 2011;28(4):351–3.CrossRefPubMed Nouri K, Bader Y, Helmy S, et al. Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J Assist Reprod Genet. 2011;28(4):351–3.CrossRefPubMed
15.
Zurück zum Zitat Lockwood GM, Ledger WL, Barlow DH. Successful pregnancy outcome in a renal transplant patient following in vitro fertilization. Hum Reprod. 1995;10:1528–30.CrossRefPubMed Lockwood GM, Ledger WL, Barlow DH. Successful pregnancy outcome in a renal transplant patient following in vitro fertilization. Hum Reprod. 1995;10:1528–30.CrossRefPubMed
16.
Zurück zum Zitat Wang JX, Norman RJ, Kristiansson P. The effect of various infertility treatments on the risk of preterm birth. Hum Reprod. 2002;17:945–9.CrossRefPubMed Wang JX, Norman RJ, Kristiansson P. The effect of various infertility treatments on the risk of preterm birth. Hum Reprod. 2002;17:945–9.CrossRefPubMed
Metadaten
Titel
An Overview on Fertility Outcome in Renal Transplant Recipients
verfasst von
Vineet V. Mishra
Sakshi S. Nanda
Kavita Mistry
Sumesh Choudhary
Rohina Aggarwal
Bhumika M. Vyas
Publikationsdatum
14.06.2016
Verlag
Springer India
Erschienen in
The Journal of Obstetrics and Gynecology of India / Ausgabe Sonderheft 1/2016
Print ISSN: 0971-9202
Elektronische ISSN: 0975-6434
DOI
https://doi.org/10.1007/s13224-016-0919-6

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