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01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Journal of Medical Case Reports 1/2016

An uncommon response to metronomic therapy in a heavily pretreated patient with metastatic carcinosarcoma: a case report

Journal of Medical Case Reports > Ausgabe 1/2016
Debora de Melo Gagliato, Rudinei Diogo Marques Linck, Regis Otaviano Franca Bezerra, Mirela Souto, Gabriel Lima Lopes, Glauco Baiocchi, Max Senna Mano
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Conception and design: DdMG and MM. Manuscript writing: all authors. All authors read and approved the final manuscript.



Uterine carcinosarcoma is well known for its aggressive behavior. There is little evidence regarding the gold standard combination chemotherapy in metastatic or locally advanced carcinosarcoma, due to poor survival outcomes obtained with conventional scheduled chemotherapy. This case report represents the first-ever reported objective response to a metronomic chemotherapy regimen and adds to the current literature.

Case presentation

We describe a case of a Caucasian woman diagnosed with metastatic carcinosarcoma that had already been treated with multiple lines of conventional chemotherapy, with progressive disease. This patient had a surprising clinical and imaging response when treated with oral metronomic cyclophosphamide.


We reviewed the mechanism of action implicated in metronomic chemotherapy, and correlated it with the biology of disease in carcinosarcoma. This information may add to the current literature, providing important insights to future clinical trials in this patient population.

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