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Current Hematologic Malignancy Reports

31.08.2023

An Update on the Management of Advanced Phase Chronic Myeloid Leukemia

verfasst von: Nicholas J. Short, Jayastu Senapati, Elias Jabbour

Erschienen in: Current Hematologic Malignancy Reports

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Abstract

Purpose of Review

While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are expected to have a normal life expectancy, some patients present with or progress to a more aggressive accelerated phase (AP) or blast phase (BP) of CML. Herein, we discuss the diagnostic considerations of advanced phase CML and review its contemporary management.

Recent Findings

Later-generation, more potent BCR::ABL1 tyrosine kinase inhibitors (TKIs) such as ponatinib may result in superior outcomes in patients with advanced phase CML. For CML-BP, combination approaches directed against the blast immunophenotype appear superior to TKI monotherapy. The role of allogeneic stem cell transplantation is controversial in CML-AP but has consistently been shown to improve outcomes for patients with CML-BP.

Summary

Advanced phase CML, particularly CML-BP, remains a poor risk subtype of CML. However, novel combination approaches using later-generation TKIs are being explored in clinical trials and may lead to improved outcomes.
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Metadaten
Titel
An Update on the Management of Advanced Phase Chronic Myeloid Leukemia
verfasst von
Nicholas J. Short
Jayastu Senapati
Elias Jabbour
Publikationsdatum
31.08.2023
Verlag
Springer US
Erschienen in
Current Hematologic Malignancy Reports
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-023-00709-4

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