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Current Hematologic Malignancy Reports

Erschienen in:

22.07.2017 | B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (D Persky, Section Editor)

An Update on the Use of Immunotherapy in the Treatment of Lymphoma

verfasst von: Thomas U. Marron, Matko Kalac, Joshua Brody

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 4/2017

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Abstract

Purpose of Review

Throughout the field of oncology, immunotherapy is moving further towards the first-line setting, and there is encouraging data for the use of these novel therapies in the management of lymphomas, utilizing treatments approved for both solid and hematologic malignancies. Herein, we review promising advances in this rapidly moving field from the past year.

Recent Findings

In the last year, we have seen promising clinical data on engineered antibody therapies for the treatment of lymphomas, as well as further optimization of engineered antibody fragments fused onto linkers or chimeric T cell receptors, both of the modalities capable of transforming non-specific T cells into tumor-specific, serial killer cells.

Summary

Here we will review the promising data on these advances in antibody-based therapies, as well as some of the immunomodulators and checkpoint-blocking therapies that shown to have promising results in the treatment of lymphomas within the past year.

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Titel: An Update on the Use of Immunotherapy in the Treatment of Lymphoma
verfasst von: Thomas U. Marron
Matko Kalac
Joshua Brody
Publikationsdatum: 22.07.2017
Verlag: Springer US
Erschienen in: Current Hematologic Malignancy Reports / Ausgabe 4/2017
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-017-0396-8

Chimeric Antigen Receptor Therapy in Acute Lymphoblastic Leukemia Clinical Practice

Acute Lymphocytic Leukemias (K Ballen, Section Editor)

Patient and Caregiver Adjustment to Hematopoietic Stem Cell Transplantation: a Systematic Review of Dyad-Based Studies

Health Economics (N Khera, Section Editor)

Therapeutic Options for Aggressive T-Cell Lymphomas

B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (D Persky, Section Editor)

Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy

CART and Immunotherapy (M Ruella, Section Editor)

Coordination of Care in Survivorship After Treatment of Hematological Malignancies—The Journey is Not Over Yet

Health Economics (N Khera, Section Editor)

Novel Immunotherapies for Multiple Myeloma

CART and Immunotherapy (M Ruella, Section Editor)

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An Update on the Use of Immunotherapy in the Treatment of Lymphoma