Background
Methods
Research objective
Questionnaire content and method
Statistical analysis
Results
General basic data analysis
Univariate analysis
Demographic and sociological indicators
Indicators | Case group (n = 27) | Control group (n = 59) |
χ
2
|
P
| |
---|---|---|---|---|---|
Gender | Male | 6 (22.2 %) | 7 (11.9 %) | 0.330* | |
Female | 21 (77.8 %) | 52 (88.1 %) | |||
Education level | Junior high school、primary school or lower | 17 (63.0 %) | 31 (52.5 %) | 0.816 | 0.366 |
Senior high school, university or higher | 10 (37.0 %) | 28 (47.5 %) | |||
Occupational status | Unemployed | 6 (22.2 %) | 6 (10.2 %) | 5.371 | 0.068 |
Student | 0 (0 %) | 8 (13.6 %) | |||
Farmer | 10 (37.0 %) | 16 (27.1 %) | |||
Worker | 4 (14.8 %) | 13 (22.0 %) | |||
Cadre or other | 7 (25.9 %) | 16 (27.1 %) | |||
Marital status | Unmarried | 0 (0 %) | 10 (16.9 %) | 5.941 | 0.051 |
Married | 24 (88.9 %) | 45 (76.3 %) | |||
Divorced or widowed | 3 (11.1 %) | 4 (6.8 %) | |||
Residence | Rural areas and suburbs | 22 (81.5 %) | 38 (64.4 %) | 2.560 | 0.110 |
City | 5 (8.5 %) | 21 (35.6 %) | |||
Household income | Less than 60,000/year | 14 (51.9 %) | 25 (42.4 %) | 0.672 | 0.413 |
More than 60,000/year | 13 (48.1 %) | 34 (57.6 %) | |||
Smoking history | No | 16 (59.3 %) | 47 (79.7 %) | 4.345 | 0.114 |
Less than 20/day | 5 (18.5 %) | 4 (6.8 %) | |||
More than 20/day | 6 (22.2 %) | 8 (16.3 %) | |||
Drinking history(per day) | No | 21 (77.78 %) | 52 (88.14 %) | 0.330* | |
Yes | 6 (22.22 %) | 7 (11.86 %) | |||
History of caffeine intake | No | 22 (81.48 %) | 52 (88.14 %) | 0.505* | |
Yes | 5 (18.52 %) | 7 (11.86 %) | |||
Other drug history and substance addiction | No | 21 (77.8 %) | 50 (84.7 %) | 0.542* | |
Yes | 6 (22.2 %) | 9 (15.3 %) | |||
Family history of headache | No | 12 (44.4 %) | 23 (39.0 %) | 0.229 | 0.632 |
Yes | 15 (55.6 %) | 36(61.0 %) | |||
MOH family history | No | 24 (88.9 %) | 57 (96.6 %) | 0.176* | |
Yes | 3 (11.1 %) | 2 (3.4 %) | |||
Family history of addiction to other drugs and substances | No | 22 (81.5 %) | 52 (88.1 %) | 0.505* | |
Yes | 5 (18.5 %) | 7 (11.9 %) |
MOH characteristics before drug withdrawal
Indicators | Case group | Control group | Statistic |
P
|
---|---|---|---|---|
Medication overuse over time(year) | 4.04 ± 1.126 | 3.37 ± 1.731 | t = 2.124 | 0.037 |
Headache frequency (days/month) | 24.07 ± 4.811 | 21.76 ± 4.573 | t = 2.140 | 0.035 |
The degree of headache (VAS) | 6 ~ 9 (8) | 6 ~ 9 (8) | Z = −1.528 | 0.127 |
Duration of each attack (h) | 10.15 ± 6.707 | 7.90 ± 5.473 | t = 1.646 | 0.103 |
Characteristics of primary headache
Indicators | Case group | Control group | Statistic |
P
|
---|---|---|---|---|
Course of primary headache | 10 ~ 45 (20) | 2 ~ 35 (8) | Z = −5.973 | < 0.001 |
Headache frequency (days/month) | 8.70 ± 2.072 | 7.12 ± 2.607 | t = 2.780 | 0.007 |
Duration of each attack (h) | 1 ~ 6 (3) | 1 ~ 12 (2) | Z = −1.922 | 0.055 |
Headache degree (VAS) | 6.22 ± 1.050 | 5.78 ± 0.966 | t = 1.918 | 0.058 |
Overuse of drugs
Indicators | Case group (n = 27) | Control group (n = 59) |
χ
2
|
P
|
---|---|---|---|---|
Use only a single component drug | 9 (33.3 %) | 14 (23.7 %) | 0.872 | 0.350 |
Use only NSAID | 6 (22.2 %) | 10 (17.0 %) | 0.340 | 0.560 |
Use only Chinese patent medicine | 3 (11.1 %) | 3 (5.1 %) | 0.373* | |
Use only benzodiazepines | 0 | 1 (1.7 %) | 1.000* | |
Combination of compound preparations or painkillers | 18 (66.7 %) | 45 (76.23 %) | 0.872 | 0.350 |
Drug use and withdrawal situation
Indicators | Case group | Control group | Statistic |
P
|
---|---|---|---|---|
Drug use frequency (days/month) | 24.26 ± 5.035 | 22.12 ± 4.521 | t = 1.982 | 0.051 |
Headache frequency After drug withdrawal (days/month) | 7.67 ± 1.961 | 3.42 ± 1.499 | t = 11.026 | < 0.001 |
Duration of each attack (h) | 1 ~ 4 (2) | 1 ~ 6 (2) | Z = −1.104 | 0.270 |
Headache degree (VAS) after drug withdrawal | 5.52 ± 1.341 | 4.85 ± 0.943 | t = 2.348 | 0.024 |
Comorbidity after drug withdrawal
Indicators | Case group (n = 27) | Control group (n = 59) |
χ
2
|
P
|
---|---|---|---|---|
Sleep disorders | 17 (62.96 %) | 27(45.76 %) | 2.193 | 0.139 |
Anxiety | 8 (29.63 %) | 11(18.64 %) | 1.299 | 0.254 |
Depression | 0 (0 %) | 1 (1.70 %) | 1.000* | |
Other symptoms | 7 (25.9 %) | 8 (13.6 %) | 0.221* |
Prevention of drug use
Application time of prevention drug | Case group (n = 27) | Control group (n = 59) |
χ
2
|
P
|
---|---|---|---|---|
< 6 months | 11 (40.74 %) | 9 (15.25 %) | 6.742 | 0.009 |
> 6 months | 16 (59.26 %) | 50 (84.75 %) |
Risk factors for preliminary screening
Indicators | Statistics |
P
|
---|---|---|
Medication overuse time | t = 2.124 | 0.037 |
Headache frequency before drug withdrawal | t = 2.140 | 0.035 |
Duration of primary headache | Z = −5.973 | < 0.001 |
Primary headache frequency | t = 2.780 | 0.007 |
Headache frequency after drug withdrawal | t = 11.026 | < 0.001 |
Severity of headache after drug withdrawal | t = 2.348 | 0.024 |
Application time of prevention drug | χ2 = 6.742 | 0.009 |
Multivariate analysis
Name of factors | B | S.E. | Wals | Df | Sig. | Exp (B) | EXP(B) 的 95 % C.I. | |
---|---|---|---|---|---|---|---|---|
lower limit | upper limit | |||||||
Years of medication overuse | 1.541 | 1.055 | 2.131 | 1 | 0.144 | 4.669 | 0.590 | 36.953 |
Headache frequency before drug withdrawal | 0.559 | 0.271 | 4.237 | 1 | 0.040 | 1.748 | 1.027 | 2.976 |
Frequency of Primary headache | 0.543 | 0.511 | 1.130 | 1 | 0.288 | 1.721 | 0.633 | 4.683 |
Duration of primary headache | 0.226 | 0.114 | 3.930 | 1 | 0.047 | 1.254 | 1.003 | 1.567 |
Headache frequency after drug withdrawal | 3.078 | 1.351 | 5.192 | 1 | 0.023 | 21.721 | 1.538 | 306.780 |
Severity of headache after drug withdrawal | -.830 | 1.002 | 0.686 | 1 | 0.407 | 0.436 | 0.061 | 3.107 |
Application time of prevention drug | −1.445 | 1.591 | 0.825 | 1 | 0.364 | 0.236 | 0.010 | 5.331 |
Constant | −38.412 | 19.384 | 3.927 | 1 | 0.048 | 0. |