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The authors declare that they have no competing interests.
Z-h Z have made substantial contributions to design, acquisition and analysis of data and writing the manuscript, S-q C have made substantial contributions to conception and design, X-q L have made the substantial contributions to design and modify the manuscript, DZ revised the manuscript, W-n L have participated in the drafting the manuscript, FH have contribution to analysis and interpretation of data, X-n C have contribution to acquisition of data, Y-l Z have participated in the design, X-x P have contribution to analysis and interpretation of data, K-q R have participated in the drafting the manuscript, J W have contribution to analysis and interpretation of data. All authors read and approved the final manuscript.
The work of developing clinical practice guidelines began just a little more than ten years ago in China. Up to now, there have been few studies about them.
To review and analyze the status of Chinese clinical practice guidelines in 1997–2007.
All Chinese guidelines from 1997–2007 were collected, and made a regression analysis, and a citation analysis for evaluating the impact of guidelines. To analyze the developing quality, the most influential guidelines were evaluated with AGREE instrument, and each guideline was evaluated to check for any updating. In order to analyze the objective and target population, all guidelines were classified and counted separately according to disease/symptom center, and whether towards specialists or general practitioners.
143 guidelines were collected. An exponential function equation was established for the trend in the number of guidelines. The immediacy index in every year was very low while the average citation rate was not. Both the percentages of highly cited and never cited were high. For the evaluation with AGREE, only the average score of clarity and presentation was high (89.9%); the remaining were much lower. Editorial independence scored 0. Only 27 (18.9%) of 143 guidelines, were found to be evidence-based. Only a few had ever been updated, with an average updating interval of 5.2 years. Only 2.1% were symptom-centered, and only 4.2% were aimed at general practitioners.
Much progress has been obtained for Chinese guidelines development. However, there were still defects, and greater efforts should be made in the future.