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Techniques in Coloproctology
Erschienen in:

23.03.2020 | Review

Anastomotic leak and cancer-specific outcomes after curative rectal cancer surgery: a systematic review and meta-analysis

verfasst von: A. Karim, V. Cubas, S. Zaman, S. Khan, H. Patel, P. Waterland

Erschienen in: Techniques in Coloproctology | Ausgabe 6/2020

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Abstract

Background

The aim of the present study was to perform a systematic review and meta-analysis of cancer-specific outcomes after curative rectal cancer surgery comparing anastomotic leak (AL) with no leak.

Methods

PubMed, Medline and Embase databases were searched to identify studies comparing cancer-specific outcomes after rectal cancer surgery in patients with AL and without. A meta-analysis with a random-effects model was used to calculate pooled odds ratios (OR) and confidence intervals (CI) for each outcome measure.

Results

A total of 18 studies were included for meta-analysis, comprising a total of 18,039 patients after curative rectal resection (1764 AL, 16,275 without AL). The overall rate of AL was 9.8%. After AL and excluding 30-day mortality there was an increased risk of local recurrence (OR 1.50; CI 1.23, 1.82), worse overall survival (OR 0.69; CI 0.60–0.81), decreased disease free survival (OR 0.51; CI 0.36–0.73) and cancer specific survival (OR 0.71; CI 0.54–0.94). Distant recurrence (OR 1.10; CI 0.89–1.37) and overall recurrence (OR 1.33; CI 0.64–2.76) were not significantly different between the two groups.

Conclusions

AL may negatively impact cancer-specific outcomes after curative rectal cancer surgery and could be considered an independent negative prognostic factor.
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Metadaten
Titel
Anastomotic leak and cancer-specific outcomes after curative rectal cancer surgery: a systematic review and meta-analysis
verfasst von
A. Karim
V. Cubas
S. Zaman
S. Khan
H. Patel
P. Waterland
Publikationsdatum
23.03.2020
Verlag
Springer International Publishing
Erschienen in
Techniques in Coloproctology / Ausgabe 6/2020
Print ISSN: 1123-6337
Elektronische ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-020-02153-5

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