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Archives of Gynecology and Obstetrics

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31.01.2019 | Gynecologic Endocrinology and Reproductive Medicine

Androgen receptor gene polymorphism and sexual function in midlife women

verfasst von: Barbara Sutter, Manuela Fehr, Conny Hartmann, Stefan Schmid, Michael Zitzmann, Petra Stute

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2019

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Abstract

Purpose

To assess the impact of serum androgen levels and androgen receptor CAG polymorphism on sexual function in 45 healthy midlife women living in a heterosexual relationship.

Methods

Cross-sectional study [Cantonal Ethics Committee Bern (Ref.-Nr. KEK-BE: 087/13)]. Main outcome measures: Association between androgen serum levels, androgen receptor CAG polymorphism and sexual function was assessed by the FSFI-d questionnaire.

Results

In our cohort of healthy, midlife, well-educated, middle-class, mostly postmenopausal women living in a heterosexual satisfying partnership, sexual function was perceived to remain stable or to decline during menopausal transition with sexual desire scoring lowest (FSFI-d 3.3 ± 0.9). Androgen serum levels did not correlate with sexual function. Mean CAG repeat number was 21.6 ± 1.9. There was a highly inverse though non-significant correlation between female sexual function and AR CAG repeat polymorphism with specifically higher numbers of CAG repeats being significantly positively correlated to more frequent or more severe pain during or after sexual intercourse.

Conclusion

The AR polymorphism is a non-negligible factor in female sexual function. Future studies on female sexual (dys)function should incorporate its assessment.

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Titel: Androgen receptor gene polymorphism and sexual function in midlife women
verfasst von: Barbara Sutter
Manuela Fehr
Conny Hartmann
Stefan Schmid
Michael Zitzmann
Petra Stute
Publikationsdatum: 31.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05052-9

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Androgen receptor gene polymorphism and sexual function in midlife women

Abstract

Purpose

Methods

Results

Conclusion

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