Mastocytosis as a risk factor for insect venom allergy
- 08.05.2020
- Angioödem
- Übersicht
- Verfasst von
- Patrizia Bonadonna
- Elisa Boni
- Roberta Zanotti
- Erschienen in
- Allergo Journal | Ausgabe 3/2020
Auszug
Hymenoptera venom allergy (HVA) is a typical IgE-mediated disease, which clinical manifestations are the result of the mast cells (MCs) degranulation, triggered by the binding of the venom allergens to specific IgEs. Anaphylaxis is the most severe expression of these clinical manifestations, which is actually a severe and potentially fatal hypersensitivity reaction that can affect patients of all ages. It is the result of MC and basophil acute activation mediated by immunological or nonimmunological mechanisms, with consecutive massive release of vasoactive and proinflammatory substances from MCs, leading to the clinical signs and symptoms of anaphylaxis. In allergic reactions, degranulation of MCs develops in the first seconds after MC activation with binding of immunoglobulins E (IgEs) to the high affinity receptor FCεRI [1]. …
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- Titel
- Mastocytosis as a risk factor for insect venom allergy
- Verfasst von
-
Patrizia Bonadonna
Elisa Boni
Roberta Zanotti
- Publikationsdatum
- 08.05.2020
- Verlag
- Springer Medizin
- Schlagwörter
-
Angioödem
Anaphylaxie
Mastozytose
Kutane Mastozytose
Systemische Mastozytose
Anaphylaxie
Innere Medizin
Allergologie in der HNO-Heilkunde
Allergien und Intoleranzreaktionen
Allergische Erkrankungen in der Hausarztpraxis - Erschienen in
-
Allergo Journal / Ausgabe 3/2020
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405 - DOI
- https://doi.org/10.1007/s15007-020-2516-3
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