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20.10.2017 | Ausgabe 7/2018

Abdominal Radiology 7/2018

Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma

Zeitschrift:
Abdominal Radiology > Ausgabe 7/2018
Autoren:
Altan F. Ahmed, Naziya Samreen, Joseph R. Grajo, Ivan Zendejas, Chris L. Sistrom, Amy Collinsworth, Ashwini Esnakula, Jehan L. Shah, Roniel Cabrera, Brian S. Geller, Beau B. Toskich
Wichtige Hinweise
Altan F. Ahmed and Naziya Samreen are co-first authors, listed alphabetically.

Abstract

Purpose

To assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.

Methods

Twelve patients with HCC underwent ablative (≥ 190 Gy) and/or non-ablative (< 190 Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT. Responses were graded using EASL and mRECIST criteria. Histologic findings including percent tumor necrosis and adjacent hepatic substrate effects were correlated with imaging features.

Results

Complete pathologic necrosis (CPN) was observed in 7/12 tumors post-TARE. Ablative and non-ablative dosing resulted in CPN in 5/6 and 2/6 tumors, respectively. Hyperintensity on T2-weighted imaging, the absence of hepatocyte-specific gadolinium contrast uptake, and plateau or persistent enhancement kinetics in the angiosome correlated with CPN and performed similarly to EASL and mRECIST criteria in predicting CPN.

Conclusions

The absence of hepatocyte-specific contrast uptake, increased signal on T2-weighted sequences, and plateau or persistent enhancement in the angiosome may represent MRI surrogates of CPN following TARE of HCC. These findings correlated with EASL and mRECIST response criteria. Further investigation is needed to determine the role of these findings as possible adjuncts to conventional imaging criteria.

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