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Erschienen in: Cardiovascular Drugs and Therapy 6/2014

01.12.2014 | ORIGINAL ARTICLE

Angiotensin-(1–7) Modulates Angiotensin II-Induced Vasoconstriction in Human Mammary Artery

verfasst von: Luís Mendonça, Pedro Mendes-Ferreira, Ana Bento-Leite, Rui Cerqueira, Mário Jorge Amorim, Paulo Pinho, Cármen Brás-Silva, Adelino F. Leite-Moreira, Paulo Castro-Chaves

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 6/2014

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Abstract

Purpose

The renin-angiotensin system plays a key role in cardiovascular pathophysiology and one of its members, angiotensin-(1–7) (ANG-(1–7)), is now recognized as a peptide with the ability to counter-regulate angiotensin II (ANGII) effects. We sought to investigate ANG-(1–7) actions in human vessels, particularly its effect on ANGII-induced vasoconstriction in human mammary arteries (HMA).

Methods

Samples of HMA from patients submitted to coronary revascularization (22 patients, mean age 67 years) were cut into small rings, mounted in a myograph bath system, normalized and allowed to contract and dilate isometrically. In baseline experiments, the rings were incubated with ANG-(1–7) or vehicle, followed by increasing concentrations of ANGII. This protocol was repeated in the presence of A-779, PD123177, losartan and after mechanical endothelium removal. Western blot analysis and immunofluorescence were also performed in order to verify the presence of Mas receptor in HMA.

Results

ANG-(1–7) significantly attenuated ANGII-induced contraction, producing a maximal inhibition of approximately 65.2 %. This effect was not abolished by A-779, PD123177 or endothelium removal. In the presence of losartan, ANGII response was attenuated and no differences were observed between ANG-(1–7) and vehicle treated rings. Finally, we observed, for the first time, that the Mas receptor is expressed in HMA endothelium.

Conclusions

ANG-(1–7) significantly attenuates ANGII-induced vasoconstriction and, although the Mas receptor is expressed in HMA, this effect seems to be independent of its activation. Additionally, AT2 receptor and endothelium are not involved in this mechanism, which suggests a direct effect on smooth muscle cells.
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Metadaten
Titel
Angiotensin-(1–7) Modulates Angiotensin II-Induced Vasoconstriction in Human Mammary Artery
verfasst von
Luís Mendonça
Pedro Mendes-Ferreira
Ana Bento-Leite
Rui Cerqueira
Mário Jorge Amorim
Paulo Pinho
Cármen Brás-Silva
Adelino F. Leite-Moreira
Paulo Castro-Chaves
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 6/2014
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-014-6555-4

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