Introduction
Subjects and methods
Patients
Gender ratio (male:female) | 1:1.7 (19:32) |
Mean age (±SD), years | 46.6 (±8.4) |
Mean age at diagnosis (±SD), years | 39.2 (±9.0) |
Median disease duration (range), months | 60 (6–240) |
Clinical manifestations: n (%) | |
Asymmetrical polyarthritis | 39 (76.5) |
Symmetrical polyarthritis | 7 (13.7) |
Oligo-arthritis | 5 (9.8) |
Spondylitis | 10 (19.6) |
Dactylitis | 24 (47.1) |
Enthesitis | 10 (19.6) |
Disease severity | |
Less severe | 32 (62.7) |
Severe | 19 (37.3) |
Controls
Genotyping
Statistical analysis
Results
ACE gene | Patients (n = 51) | Controls (n = 100) |
P values | OR (95% CI) |
---|---|---|---|---|
Genotype no (%) | ||||
DD | 25 (49) | 41 (41) | 0.4 | 1.38 (0.7–2.7) |
ID | 19 (37) | 45 (45) | 0.4 | 0.7 (0.4–1.4) |
II | 7 (14) | 14 (14) | 1.0 | 1.0 (0.4–2.5) |
Allele frequency | ||||
D | 0.7 | 0.6 | 0.6 | 1.2 (0.7–2.0) |
I | 0.3 | 0.4 | 0.6 | 0.8 (0.5–1.4) |
PsA patient characteristic |
n = 51 | Genotype no. (%) | Allele | |||
---|---|---|---|---|---|---|
DD | ID | II | D | I | ||
Age at onset of PsA | ||||||
Onset ≤ 40 years | 27 | 14 (53) | 12 (44) | 1 (3) | 0.74 | 0.26 |
Onset > 40 years | 24 | 11 (46) | 7 (29) | 6 (25)a
| 0.60 | 0.40 |
Family history | ||||||
Positive | 22 | 9 (41) | 11 (50) | 2 (9) | 0.73 | 0.27 |
Negative | 29 | 16 (55) | 8 (28) | 5 (17) | 0.65 | 0.35 |