Angiotensin II receptor blocker irbesartan attenuates sleep apnea–induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation
- 09.10.2021
- Sleep Breathing Physiology and Disorders • Original Article
Erschienen in:
- Verfasst von
- Pei-Ying Pai
- Yi-Yuan Lin
- Shao-Hong Yu
- Ching-Yuang Lin
- Yi-Fan Liou
- Xu-Bo Wu
- James K. S. Wong
- Chih-Yang Huang
- Shin-Da Lee
- Erschienen in
- Sleep and Breathing | Ausgabe 3/2022
Abstract
Background
The purpose of this study was to investigate whether or not angiotensin II type 1 receptor blocker irbesartan (ARB) with a partial agonist of PPAR-γ could protect against chronic nocturnal intermittent hypoxia (CIH)–induced cardiac Fas/FasL-mediated to mitochondria-mediated apoptosis.
Methods
Sprague–Dawley rats were in a normoxic control group (CON-G), or rats were in a chronic nocturnal intermittent hypoxia group (HP-G, from 3 to 7% oxygen versus 21% oxygen per forty seconds cycle, nocturnally 8 h per day for 1 month), or rats were in a chronic nocturnal intermittent hypoxia group pretreated with ARB (50 mg/kg/day, S.C.) (ARB-HP-G). Echocardiography, H&E staining, TUNEL staining, and Western blotting were measured in the left ventricle.
Results
Hypoxia-induced SIRT1 degradation, Fas receptors, FADD, active caspase-8 and caspase-3 (Fas/FasL apoptotic pathway) and Bax, tBid, active caspase-9 and -3 (mitochondrial apoptotic pathway) and TUNEL-positive apoptosis were reduced in ARB-HP-G when compared with HP-G. IGF-I, IGF1 receptor, p-PI3k, p-Akt, Bcl2, and Bcl-XL (IGF1/PI3K/AKT pro-survival pathway) were increased in ARB-HP-G compared to HP-G.
Conclusions
Our findings suggest that the ARB may prevent cardiac Fas/FasL to mitochondrial apoptotic pathways and enhance cardiac IGF1/PI3K/AKT pro-survival pathway in the sleep apnea model associated with JNK de-activation and SIRT1 upregulation. ARB prevents chronic sleep apnea–enhanced cardiac apoptosis via enhancing survival pathways.
Anzeige
- Titel
- Angiotensin II receptor blocker irbesartan attenuates sleep apnea–induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation
- Verfasst von
-
Pei-Ying Pai
Yi-Yuan Lin
Shao-Hong Yu
Ching-Yuang Lin
Yi-Fan Liou
Xu-Bo Wu
James K. S. Wong
Chih-Yang Huang
Shin-Da Lee
- Publikationsdatum
- 09.10.2021
- Verlag
- Springer International Publishing
- Erschienen in
-
Sleep and Breathing / Ausgabe 3/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709 - DOI
- https://doi.org/10.1007/s11325-021-02499-6
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
