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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Diabetology & Metabolic Syndrome 1/2014

Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats

Zeitschrift:
Diabetology & Metabolic Syndrome > Ausgabe 1/2014
Autoren:
Erik Salum, Mark Butlin, Jaak Kals, Mihkel Zilmer, Jaan Eha, Alberto P Avolio, Andres Arend, Marina Aunapuu, Priit Kampus
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1758-5996-6-57) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

ES performed the experiments, participated in performing the statistical analysis, and drafted the manuscript. MB and APA performed statistical analysis, participated in the study design and coordination, and helped to draft the manuscript. ES, PK, JK, MZ, JE conceived of the study, participated in its design and coordination, and helped to draft the manuscript. MA and AA performed the histological analyses and helped revising the manuscript. All authors have read and approved the final manuscript.

Abstract

Background

Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction. The present study aimed to investigate the effects of telmisartan, an angiotensin II type 1 receptor blocker (ARB), on blood pressure, aortic stiffening, and aortic remodelling in experimental type 1 diabetes in rats.

Methods

Diabetes was induced by streptozotocin (STZ) (65 mg/kg) in male Wistar rats. One diabetic group was treated for 10 weeks with telmisartan (10 mg/kg/day p/o). Pressure-independent aortic pulse wave velocity (PWV) was measured under anaesthesia after intravenous infusion of phenylephrine and nitroglycerine. Aortic wall samples were collected for histomorphometrical analysis.

Results

Untreated diabetes imposed differential effects on aortic stiffening, as demonstrated by increased isobaric PWV over a range of high blood pressures, but not at lower blood pressures. This was associated with loss and disruption of elastin fibres and an increase in collagen fibres in the aortic media. Treatment with telmisartan decreased resting blood pressure, reduced aortic stiffness, and partially prevented the degradation of elastin network within the aortic wall.

Conclusions

Telmisartan improved the structural and functional indices of aortic stiffening induced by untreated STZ-diabetes, demonstrating the importance of ARBs in the therapeutic approach to diabetic vascular complications.
Zusatzmaterial
Authors’ original file for figure 1
13098_2013_322_MOESM1_ESM.pdf
Authors’ original file for figure 2
13098_2013_322_MOESM2_ESM.tiff
Authors’ original file for figure 3
13098_2013_322_MOESM3_ESM.tiff
Authors’ original file for figure 4
13098_2013_322_MOESM4_ESM.tiff
Literatur
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