Skip to main content
main-content

20.10.2015 | Retinal Disorders | Ausgabe 7/2016

Graefe's Archive for Clinical and Experimental Ophthalmology 7/2016

ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 7/2016
Autoren:
Qianyi Lu, Wenjun Zou, Bin Chen, Chen Zou, Minjie Zhao, Zhi Zheng
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00417-015-3187-8) contains supplementary material, which is available to authorized users.
Qianyi Lu and Wenjun Zou contributed equally to this work.

Abstract

Purpose

To investigate the relationship between angiopoietin-like protein 4 (ANGPTL-4) and vascular endothelial growth factor (VEGF) in the serum and vitreous of eyes in patients with proliferative diabetic retinopathy (PDR).

Methods

Thirty-five eyes of 35 patients with PDR, 20 eyes of 20 patients with non-proliferative diabetic retinopathy, 20 eyes of 20 patients with diabetes but no diabetic retinopathy, and 14 eyes of 14 nondiabetic patients with an idiopathic macular hole (IMH) were recruited from Shanghai First People’s Hospital. The ANGPTL-4 and VEGF concentrations were determined using enzyme-linked immunosorbent assays. Group means were compared using one-way analysis of variance with GraphPad Prism 4.0 and SPSS ver. 17.0. The research followed the tenets of the Declaration of Helsinki.

Results

The ANGPTL-4 and VEGF levels were significantly higher in the vitreous and serum of patients with PDR compared with patients with IMH. There were significant correlations between the ANGPTL-4 and VEGF levels in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated in patients with PDR. The ANGPTL-4 in both the vitreous and serum correlated with the serum triglyceride and high-density lipoprotein cholesterol levels.

Conclusions

The ANGPTL-4 levels were markedly elevated and the ANGPTL-4 expression was directly correlated with the VEGF expression in the vitreous and serum of patients with PDR. The vitreous and serum ANGPTL-4 levels were also significantly correlated with serum lipids in patients with PDR. Our results suggest that the ANGPTL-4 may be used as a new therapeutic target for the treatment of PDR.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Zusatzmaterial
Supplementary Table 1 One-sample Kolmogorov–Smirnov test. (DOC 36 kb)
417_2015_3187_MOESM1_ESM.doc
Supplementary Table 2 Pearson’s correlation tests with r and p values between ANGPTL-4 and other factors in PDR patients. (DOC 31 kb)
417_2015_3187_MOESM2_ESM.doc
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 7/2016

Graefe's Archive for Clinical and Experimental Ophthalmology 7/2016 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

07.09.2018 | Video plus | Ausgabe 11/2018

Einseitige kombinierte Augenmuskeloperation zur Korrektur der Esotropie

Videobeitrag zur Rücklagerung des M. rectus medialis und Faltung des M. rectus lateralis

24.08.2018 | Leitlinien, Stellungnahmen und Empfehlungen | Ausgabe 10/2018

Stellungnahme von BVA, DOG und RG zur intravitrealen Therapie des visusmindernden Makulaödems bei retinalem Venenverschluss

Therapeutische Strategien, Stand 24.04.2018

20.08.2018 | Rehabilitation | CME | Ausgabe 10/2018 Open Access

Aktuelle Möglichkeiten der visuellen Rehabilitation

17.08.2018 | Das therapeutische und diagnostische Prinzip | Ausgabe 11/2018

Suprachoroidale Hydrogelplombe