Ausgabe 9/2025
Inhalt (60 Artikel)
Tandem autologous hematopoietic stem cell transplantation in multiple myeloma: A historical perspective and current challenges
- Open Access
- Review
Xueting Wang, Yushan Cui, Yaomei Wang, Baijun Fang
Expanding the frontier of CAR therapy: comparative insights into CAR-T, CAR-NK, CAR-M, and CAR-DC approaches
- Open Access
- Review
Yiling Zhang, Rong Hu, Xiaoling Xie, Yuhua Li
An unconquered challenge in MDS: review of pathophysiology, clinical manifestations, and management options of MDS with thrombocytopenia
- Open Access
- Review
Xiaoyi Chen, Mihir Shukla, Jun H. Choi
Prime-time for LncRNA signatures in acute myeloid leukemia?
- Open Access
- Review
Zhiyao Ren, Barbara De Moerloose, Tim Lammens
Impact of FLT3 mutation on its intracellular localization and implications for anti-leukemia strategy
- Open Access
- Review
Fei Song, Long Su, Sujun Gao
Prognostic factors and effect modifiers in patients with relapsed or refractory follicular lymphoma who failed at least two lines of therapy: a systematic literature and expert clinical review
- Open Access
- Review
Pau Abrisqueta, Ana Jiménez-Ubieto, Ángel Serna, Irene Zamanillo, Yuting Kuang, Jennifer Uyei, Mohsin Shah, Laura Walsh, Eileen Thorley, Krystal Cantos, Emaan Rashidi, Qiufei Ma, Jessica J. Jalbert, Alexi N. Archambault, Yingxin Xu, Shivani Aggarwal, Srikanth Ambati, Hesham Mohamed, Christian Hampp, Bastian von Tresckow
Genetic biomarkers and crucial cell subsets of iron metabolism in Beta-Thalassemia: insights from bioinformatics and experimental validation
- Open Access
- Research
Renrong Wei, Dan Qiu, Xiangxing Zeng
Elevated fibrosis‑4 index is associated with 30-day mortality in adult hemophagocytic lymphohistiocytosis patients
- Open Access
- Research
Jun Zhou, Mengxiao Xie, Mingjun Xie, Zhi-Qi Wu Wu, Hua-Guo Xu
Framework for the comprehensive screening for endocrine disorders in patients with transfusion-dependent thalassemia in low-resource settings
- Open Access
- Research
Saadia Abbas, Muhammad Osama Khan, Aahan Arif, Hafsa Majid, Lena Jafri, Aisha Shaikh, Khadija Humayun, Aysha Habib Khan, Bushra Moiz
Comprehensive analysis of the clinical feature, myeloid neoplasm-related gene mutation profiles and T cell diversity acquired pure red cell aplasia
- Open Access
- Research
Yuemin Gong, Xingxing Chai, Xiaoqing Liu, Yawen Zhang, Yue Li, Yunlong Li, Jianping Hao, Guangsheng He
Severity patterns and predictors of sickle cell anaemia among Gambian children: A cross-sectional analysis
- Open Access
- Research
Lamin Makalo, Muhammed Manka, Orlianys Ruiz Perez, Sheikh Joof, Fatoumatta Jitteh, Musa Touray, Cessare Medri
Hemoglobin levels and frailty status in generally healthy and active community-dwelling adults age 70 years and older in the three-year DO-HEALTH study
- Open Access
- Research
Simon Broghammer, Michael Gagesch, Maud Wieczorek, Reto W. Kressig, Markus G. Manz, E. John Orav, Heike A. Bischoff-Ferrari
Is splenectomy one of the contributory factors to pulmonary hypertension? An analysis of splenectomized hemolytic anemia and immune thrombocytopenia patients
- Open Access
- Research
Zeliha Birsin, Ayşe Salihoğlu, Kardelen Ohtaroğlu Tokdil, Betül Zehra Pirdal, Seçkin Bilgiç, Burçak Kılıçkıran Avcı, Deniz Özmen, Ahmet Emre Eşkazan, Muhlis Cem Ar, Zafer Başlar, Tuğrul Elverdi
Prognostic value of laboratory biomarkers for mortality risk stratification in thrombotic thrombocytopenic purpura
- Open Access
- Research
Xu Xiang, Yue-qing Dai
Genetic analysis of thalassemia in putian: comparative insights into mutation spectra with other global regions
- Open Access
- Research
Liumin Yu, Guanghui Xu, Zhanfei Chen, Kun Lin, Jinqiu Li, Hua Lin
AI-based detection of neutrophil dysplasia: an accessible and sensitive model for MDS diagnosis from peripheral blood
- Open Access
- Research
Nicole H. Romano, Christian Ruiz, Pascal Schlaepfer, Stefan Balabanov, Stefan Habringer, Corinne C. Widmer
PNH clones prevalence study in ph-negative myeloproliferative neoplasms: a multicenter Italian study
- Open Access
- Research
Alessandra D’Addio, Michela Rondoni, Marzia Salvucci, Giovanni Marconi, Massimiliano Bonifacio, Ilaria Tanasi, Omar Perbellini, Giuseppe Carli, Patrizia Tosi, Simona Tomassetti, Giovanni Poletti, Evita Massari, Marco Rosetti, Elisabetta Fabbri, Chiara Zingaretti, Alessandro Lucchesi, Maria Teresa Bochicchio, Giorgia Simonetti, Mauro Krampera, Francesco Lanza
Challenges in accuracy in molecular genetic diagnosis of childhood AML: case series
- Open Access
- Research
Fernanda de Oliveira Mota, Silva Regina Caminada de Toledo, Francine Tesser-Gamba, Michele Gaboardi de Carvalho Pires, Juliana Thomazini Gouveia, Indhira Dias Oliveira, Nancy da Silva Santos, Elizabete Delbuono, Bruno Nicolaz Rhein, Renata Fittipaldi da Costa Guimarães, Victor Gottardello Zecchin, Maria Lucia de Martino Lee, Ana Virginia Lopes de Sousa
Comparative efficacy of venetoclax and hypomethylating agents in acute myeloid leukemia treatment: a meta-analysis of clinical trials and Real-World outcomes
- Open Access
- Research
Antonio Sanz-Solas, Miriam Saiz-Rodríguez, Sara Calvo Simal, Rebeca Rodríguez-Veiga, Antonio Solana-Altabella, Pau Montesinos, Jorge Labrador
Survival analysis and prognosis model construction of elderly patients with acute promyelocyticleukemia: a retrospective study based on SEER database
- Open Access
- Research
Jinhong Jiang, Yonghua Liu, Yuxiao Zeng, Yifen Lan, Bingmu Fang
Genetic insights into myeloproliferative neoplasms and unusual sites thrombosis
- Open Access
- Research
Erika Morsia, Paola Ranalli, Stefano Baldoni, Stefania. Mancini, Sonia Morè, Chiara Cantò, Dorela Lame, Gaetano La Barba, Antonella Poloni, Serena Rupoli, Mauro Di Ianni
Comparison of prognostication by IPSS-M, IPSS-R and AIPSS-MDS in the context of limited availability of molecular data in daily clinical practice
- Open Access
- Research
Felicitas Schulz, Carolin Kellersmann, Beate Betz, Barbara Hildebrandt, Annika Kasprzak, Corinna Strupp, Felicitas Thol, Michael Heuser, Christina Ganster, Fabian Beier, Katja Sockel, Wolf-Karsten Hofmann, Andrea Kuendgen, Paul Jaeger, Michael Pfeilstoecker, Michael Lauseker, Sascha Dietrich, Nobert Gattermann, Kathrin Nachtkamp, Detlef Haase, Ulrich Germing
Clinical outcomes with high dose cytarabine and idarubicin consolidation for adult AML patients
- Open Access
- Research
Bingxin Qian, Guiqin Huang, Xiaoya Cai, Ying Liu, Dengju Li, Jin Yin
Internal tandem duplications of FLT3 containing exogenous sequences are associated with poor clinical outcomes in acute myeloid leukemia
- Open Access
- Research
Shao-Tong Li, Xiu-Min Shi, Qiu-Ju Liu, Ye-Hui Tan, Hai Lin, Yan-Ping Yang, Jing-Nan Sun, Yun-Wei Zhang, Long Su, Su-Jun Gao
Clinical profile and treatment outcomes in paediatric and adult acute promyelocytic leukemia: experience from a tertiary care centre in Northern India
- Open Access
- Research
Harshal Mamlekar, Nandhini Gangadaran, Sanjeev Yadav, Rajesh Kashyap, Khaliqur Rahman, Ruchi Gupta, Manish Singh, Dinesh Chandra, Mona Vijayaran, Prisha Nankana
Treatment persistence and overall survival in myelofibrosis treated with ruxolitinib were not affected by the covid-19 pandemic, despite the reduced starting dose: Analysis of AIFA registries
- Open Access
- Research
Massimo Breccia, Simone Celant, Francesca Palandri, Francesco Passamonti, Pier Paolo Olimpieri, Valentina Summa, Annalisa Guarcello, Giuseppe Alberto Palumbo, Fabrizio Pane, Paola Guglielmelli, Pierluigi Zinzani, Paolo Corradini, Pierluigi Russo
Transcriptome-based molecular subgroup identification and prognosis stratification in pediatric AML
- Open Access
- Research
YuWei Huang, MuYao Yang, JiaQi Hu, TingYuan Lang, JianWen Xiao
Impact of best response to ibrutinib plus Bendamustine and rituximab on PFS in MCL: a secondary analysis of SHINE
- Open Access
- Research
Yuko Mishima, Daigo Hashimoto, Michiko Ichii, Noriko Fukuhara, Toshiki Uchida, Koji Kato, Ai Omi, Yosuke Koroki, Kaname Shiga, Dai Maruyama
Efficacy of radiotherapy in primary mediastinal diffuse large B-cell lymphoma: a systematic review and meta-analysis of 1,392 patients
- Open Access
- Research
Dongyu Zhuang, Silan Huang, Peng Zhang, Dexin Lei, Yanlou Wang, Honglian Liu, Man Nie, Yi Xia
Follicular lymphoma or diffuse large B-cell lymphoma: a population based analysis of epidemiological and health economic aspects in Germany
- Open Access
- Research
Karin Berger, Bernhard Moertl, Michael von Bergwelt-Baildon, Dominik Obermüller, Dorota Pawlowska-Phelan, Martin Dreyling
T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults
- Open Access
- Research
Emna Azza, Aya Ben Othmen, Maroua Bahri, Roua Hsasna, Raihane Ben Lakhel, Yosr Ben Abdennebi, Lamia Aissaoui
Real-world study on patient characteristics, treatment patterns and outcomes for treated patients with chronic lymphocytic leukemia during 2013–2022 in Finland
- Open Access
- Research
Juha Ranti, Sanaz Jamalzadeh, Eleonora Mäkelä, Johanna Vikkula, Essi Havula, Sari Luopajärvi, Vesa Lindström
Lenalidomide–rituximab with high-dose methotrexate for treatment of patients with newly diagnosed primary cns lymphoma: a promising first-line approach
- Open Access
- Research
Xiaoli Chang, Huanyuan Wang, Yixian Guo, Qiang Ma, Zhilian Zhao, Dongmei Zou, Jing Ni, Ronghua Hu, Hong Zhao, Wuhan Hui, Li Su, Wanling Sun
Impact of clinical response and treatment tolerability on HRQoL in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia patients treated with ponatinib or imatinib
- Open Access
- Research
Ajibade Ashaye, Ling Shi, Ibrahim Aldoss, Pau Montesinos, Pankit Vachhani, Vanderson Rocha, Cristina Papayannidis, Jessica T. Leonard, Maria R. Baer, Jose-Maria Ribera, Yanyu Wu, Meliessa Hennessy, Alexandar Vorog, Shien Guo
Real-world outcomes and prognostic factors in primary mediastinal B-cell lymphoma: a multicenter study of 157 patients
- Open Access
- Research
Selin Küçükyurt, Oguzhan Koca, Esra Terzi Demirsoy, Serkan Akın, Ali Doğan, Deniz Gören, Ahmet Yiğitbaşı, Osman Şahin, Yıldız İpek, Rafiye Çiftçiler, Fahri Şahin, Meral Uluköylü Mengüç, Işıl Erdoğan Özünal, Özge Soyer Kösemehmetoğlu, Yasemin Özgür, Figen Atalay, Hacer Berna Afacan Öztürk, Merve Yüksel, Nesibe Taşer Kanat, Ayşe Uysal, Utku İltar, Abdulkerim Yıldız, Fatma Keklik Karadağ, Mehmet Baysal, Mehmet Can Uğur, Serkan Güven, İbrahim Ethem Pınar, Özgür Mehtap, İbrahim Barışta, Ahmet Muzaffer Demir, Mahmut Yeral, Cem Selim, Güray Saydam, Işık Kaygusuz Atagündüz, Pınar Tığlıoğlu, İmdat Dilek, Mesut Ayer, Ahmet Kürşad Güneş, Meltem Kurt Yüksel, Ali Ünal, Ozan Salim, Nur Soyer, Elif Birtaş Ateşoğlu, Ahmet Emre Eşkazan
The clinical features and outcomes of aggressive large B cell lymphoma with concomitant hemophagocytic lymphohistiocytosis at diagnosis
- Open Access
- Research
Lixia Zhu, Mengqi Xiong, Zixi Wang, Li Li, Jingsong He, Lijun Wang, He Huang, Xiujin Ye
Integrating genomic and transcriptome features for characterization and prognostic prediction of angioimmunoblastic T-cell lymphoma
- Open Access
- Research
Chong Wei, Congwei Jia, Yan Zhang, Danqing Zhao, Wei Zhang, Daobin Zhou
Global burden of acute lymphoblastic leukemia following the COVID-19 pandemic
- Open Access
- Research
Hongxuan Fan, Yafen Yang, Yanyan Lu, Jiahui Li, Zhuolin Huang, Zhaoyu Ren, Boda Zhou
Prognostic value of baseline body composition parameters from 18F-FDG PET/CT in angioimmunoblastic T-cell lymphoma patients
- Open Access
- Research
Huanyu Gong, Jingjie Shang, Jianyong Li, Chongyang Ding, Hao Xu, Lijun Tang, Yong Cheng
Outcomes of primary CNS lymphoma treated with combined immunochemotherapy with whole-brain radiotherapy
- Open Access
- Research
Ya Hwee Tan, Ryan Mao Heng Lim, Jing Yuan Tan, Boon Yee Lim, Nur Ayuni Binte, Muhammad Taib, Choon Kiat Ong, Chee Leong Cheng, Kheng Wei Yeoh, Soon Thye Lim, Jason Yongsheng Chan
An Italian real-world multicenter study of patients with refractory/relapsed functional high-risk multiple myeloma patients treated with second-line therapies
- Open Access
- Research
Danilo De Novellis, Salvatore Palmieri, Stefano Rocco, Daniele Derudas, Roberta Della Pepa, Daniela Roccotelli, Daniela Esposito, Chiara Masucci, Emilia Gigliotta, Maria Lucia Barone, Emanuela Morelli, Antonio Lazzaro, Rosario Bianco, Fabrizio Accardi, Luana Marano, Matteo Bonanni, Anna Maria Della Corte, Bianca Serio, Eleonora Urciuoli, Michela Rizzo, Raffaele Fontana, Manuela Arcamone, Rossella Iula, Anna Dandolo, Aldo Leone, Maria Gabriella Rascato, Maria Di Perna, Antonietta Pia Falcone, Lucia Morello, Gianpaolo Marcacci, Nunziata Giuseppe Rodolfo, Ferdinando Frigeri, Catello Califano, Angelo Michele Carella, Antonio Maria Risitano, Mario Annunziata, Fabrizio Pane, Valentina Giudice, Cirino Botta, Carmine Selleri
An international prognostic index to predict the early chemoimmunotherapy failure of diffuse large B-cell lymphoma
- Open Access
- Research
Qifan Xu, Yang Li, Beibei Xin, Chenyang Wang, Xinya Tao, Shihai Li, Hui Xiong, Xiaohua Zhou, Li Wang, Weili Zhao
“B” symptoms and CBV conditioning negatively impact survival in mantle cell lymphoma patients undergoing autologous stem cell transplantation
- Open Access
- Research
Karolina Chromik, Agata Wieczorkiewicz-Kabut, Patrycja Zielińska, Anna Koclęga, Sabina Kadłubek, Jakub Kamiński, Grzegorz Helbig
Advancement of clinical practice in delivering CAR T-cell therapy: impact on healthcare resource utilization and comparison with autologous stem cell transplantation in patients with relapsed/refractory large B-cell lymphomas
- Open Access
- Research
Martin Fehr, Matthias Naegele, Michael Greiling
Comparative efficacy and safety of BCMA-targeted CAR T cells and BiTEs in relapsed/refractory multiple myeloma: a meta-analysis of interventional and real-world studies
- Open Access
- Research
Pisanupong Techaapornkun, Waranyoo Rojpalakorn, Nuthchaya Mejun, Asmita Khaniya, Arsa Thammahong, May Soe Thu, Nattiya Hirankarn, Palada Pitakkitnukun
Mesenchymal stem cells for the adjunctive treatment of cytomegalovirus pneumonia in hematopoietic stem cell transplant recipients: a Single-center prospective study
- Open Access
- Research
Xianghui Liu, Xin Xia, Lingyun Bian, Zaihong Shen, Kun Zhou, Liping Wan, Xianmin Song, Yin Tong
A cohort of allogeneic hematopoietic stem cell transplantation for pediatric rare diseases (allo-HSCT-PRD): design and preliminary results
- Open Access
- Research
Shiwen Hu, Ping Wang, Zifeng Li, Wenjin Jiang, Lian Liu, Wenjuan Ma, Ying Huang, Xiaochuan Wang, Xiaonan Du, Xiaowen Qian, Hongsheng Wang, Yi Wang, Yunhui Zhang, Xiaowen Zhai
“In situ” MYC rearrangement and amplification as a secondary change in a case of High-grade B cell lymphoma with 11q aberration
- Open Access
- Case Report
Gioia Di Stefano, Susanne Bens, Anja Fischer, Manuel Ciceri, Luca Nassi, Reiner Siebert, Raffaella Santi
Anti-plasma cell therapy in patients with monoclonal gammopathy-associated refractory pure red cell aplasia: A report of three cases and literature review
- Open Access
- Case Report
Li Huang, Meng Li, Ting Niu, Hong Chang
Rare germline ETV6 variant associated with thrombocytopenia and acute leukemia
- Open Access
- Case Report
Akhil Rajendra Kurup, Janet Malcolmson, Anita Villani, Raymond H. Kim, Karen WL Yee
Ravulizumab stabilizes life-threating intravascular hemolysis following delayed hemolytic transfusion reaction due to alloantibodies anti-e and anti-Jka: the first successful administration
- Open Access
- Case Report
Zoe Bezirgiannidou, Iliana Stamatiou, Theodoros M. Theodoridis, Eftychia Kontekaki, Emmanouil Panagiotopoulos, Christina Misidou, George Vrachiolias, Bouse Malkots, Menelaos Papoutselis, Ioannis Kotsianidis, Emmanouil Spanoudakis, Konstantinos Liapis
Rapid withdrawal of voxelotor can precipitate sickle cell disease related crisis
- Open Access
- Case Report
Salam Alkindi, Ahmed Al Subhi, Anil Pathare
High complicated incidence of Gilbert’s syndrome in patients with thalassemia: deserve earlier identification and less oversight
- Open Access
- Correspondence
Tianyi Lai, Yaonan Hong, Peicheng Wang, Qi Liu, Yingying Shen, Wanzhi Jiang, Xiawan Yang, Yiping Shen, Shan Liu, Dijiong Wu
Enasidenib as treatment for AML with IDH2 mutation: multicenter real-life study of the early-access program in Spain
- Open Access
- Correspondence
Carlos Jiménez-Vicente, Paola Beneit, Isabel Cano-Ferri, Brayan Merchán, Montserrat Arnan, Antoni García Guiñón, Cristina Martínez-Bilbao, Ana Alfonso, Pilar Martínez-Sánchez, Juan Manuel Alonso-Domínguez, Oriana López-Godino, Sandra Castaño-Díez, Inés Zugasti, Jordi Esteve, Marina Díaz-Beyá, Adolfo de la Fuente
TRAF3IP3::FGFR1: a novel FGFR1 fusion identified in an aggressive case of acute myeloid leukemia
- Open Access
- Correspondence
Xue Chen, Lili Yuan, Xiaoli Ma, Fang Wang, Yang Zhang, Panxiang Cao, Ping Wu, Tong Wang, Jiaqi Chen, Xiaosu Zhou, Hongxing Liu
The c.2031–2A>C MPO gene variant and the predisposition to myeloid neoplasms
- Open Access
- Correspondence
Maria Crocioni, Carlotta Nardelli, Anair Graciela Lema Fernandez, Valentina Pierini, Emanuela Falcinelli, Giuseppe Lanzarone, Caterina Matteucci, Cristina Mecucci
Cryoglobulinemic vasculitis flare after daratumumab
- Open Access
- Correspondence
Mathijs Willemsen, Myrurgia Abdul-Hamid, Michel van Gelder, Pieter van Paassen, Sjoerd AMEG Timmermans
Filgrastim after autologous stem cell transplantation shortens time to neutrophil recovery and hospital stay
- Open Access
- Correspondence
K. A. Oosterink, T. J. A. Dekker, J. M. L. Tjon, W. A. F. Marijt, L. C. J. te Boome, H. Veelken, P. A. von dem Borne, C. J. M. Halkes
Successful repeated endoscopic balloon dilatation for esophageal stricture as chronic graft‐versus‐host disease
- Open Access
- Correspondence
Erika Sekiguchi, Masatoshi Sakurai, Takahiro Inoue, Kyoko Masuda, Yusuke Kubota, Takahide Shindo, Tomohiko Tanigawa, Akihiko Chida, Jun Kato, Hirofumi Kawakubo, Keisuke Kataoka
Analytical considerations affecting plasma free haemoglobin, the haemolysis index, and correlation with clinical outcomes in sickle cell disease
- Open Access
- Correspondence
Guillaume Feugray, Julie Fettig, Valéry Brunel
