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29.03.2017 | Brief Report

Anti-glomerular basement membrane glomerulonephritis with thrombotic microangiopathy: a case report

verfasst von: Xiao-juan Yu, Sha-sha Han, Su-xia Wang, Xiao-yu Jia, Wei-yi Guo, Zhao Cui, Feng Yu, Fu-de Zhou, Ming-hui Zhao

Erschienen in: Immunologic Research | Ausgabe 4/2017

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Excerpt

Anti-glomerular basement membrane (GBM) disease is a rare autoimmune disorder characterized by anti-GBM autoantibodies, rapidly progressive glomerulonephritis with substantial crescents formation, and occasionally accompanied by diffuse alveolar hemorrhage [1]. Thrombotic microangiopathy (TMA) is characterized by endothelial injury due to various causes followed by microthrombi formation, microangiopathic hemolysis, consumptive thrombocytopenia, and multiple end-organs ischemic damage. The coexistence of anti-GBM disease and TMA is rarely reported [2‐9]. Herein, we presented a case of anti-GBM disease combined with renal biopsy-proven TMA. Plasma levels of complement components were measured. Additionally, complement and coagulation system genes were sequenced to provide some insights into the combination of the two rare diseases. …

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Titel: Anti-glomerular basement membrane glomerulonephritis with thrombotic microangiopathy: a case report
verfasst von: Xiao-juan Yu
Sha-sha Han
Su-xia Wang
Xiao-yu Jia
Wei-yi Guo
Zhao Cui
Feng Yu
Fu-de Zhou
Ming-hui Zhao
Publikationsdatum: 29.03.2017
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 4/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-017-8918-y

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