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Arthritis Research & Therapy

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01.12.2005 | Review

Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options

verfasst von: Nathalie Costedoat-Chalumeau, Zahir Amoura, Elisabeth Villain, Laurence Cohen, Jean-Charles Piette

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2005

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Abstract

Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed.

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Titel: Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options
verfasst von: Nathalie Costedoat-Chalumeau
Zahir Amoura
Elisabeth Villain
Laurence Cohen
Jean-Charles Piette
Publikationsdatum: 01.12.2005
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2005
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1690

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