Antibodies to DNA repair proteins in headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) patients
- 01.06.2015
- Original Article
Erschienen in:
- Verfasst von
- Ece Erdağ
- Neşe Çelebisoy
- Ayşe Nur Yüceyar
- Murat Kürtüncü
- Burçak Vural
- Erdem Tüzün
- Erschienen in
- Acta Neurologica Belgica | Ausgabe 2/2015
Abstract
Autoimmune mechanisms have been implicated in the pathogenesis of headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). Pooled sera of five HaNDL patients and 30 controls (10 multiple sclerosis patients, 10 migraine patients, 10 healthy controls) were screened by protein macroarray. All sera were also individually subjected to immunoprecipitation with neuroblastoma cells and the bound antigens were identified by mass spectrometry. Antibodies to three DNA repair proteins (mitogen-activated protein kinase-4, DNA-dependent protein kinase catalytic subunit, DNA excision repair protein ERCC-6) were identified by both macroarray and immunoprecipitation methods in 3/5 HaNDL sera, but in none of the controls. The presence of DNA repair protein antibodies indicates DNA damage and provides further support for the inflammatory etiology of HaNDL.
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- Titel
- Antibodies to DNA repair proteins in headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) patients
- Verfasst von
-
Ece Erdağ
Neşe Çelebisoy
Ayşe Nur Yüceyar
Murat Kürtüncü
Burçak Vural
Erdem Tüzün
- Publikationsdatum
- 01.06.2015
- Verlag
- Springer Milan
- Erschienen in
-
Acta Neurologica Belgica / Ausgabe 2/2015
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993 - DOI
- https://doi.org/10.1007/s13760-014-0334-7
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