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11.12.2018 | Original Article

Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate

verfasst von: Luhana Santos Gonzales Garcia, Alberto Carlos Botazzo Delbem, Juliano Pelim Pessan, Matheus dos Passos Silva, Francisco Nunes Souza Neto, Luiz Fernando Gorup, Emerson Rodrigues de Camargo, Marcelle Danelon

Erschienen in: Clinical Oral Investigations | Ausgabe 9/2019

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Abstract

Objective

To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ.

Methods

This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6×/day). Blocks were treated 3×/day with the following toothpastes: no F/HMP/HMPnano (Placebo), conventional fluoride toothpaste, 1100 ppm F (1100F), 1100F + 0.5% micrometric HMP (1100F/HMP), and 1100F + 0.5% nano-sized HMP (1100F/HMPnano). The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN), and enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilms formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, followed by Student–Newman–Keuls’ test (p < 0.001).

Results

1100F/HMPnano promoted the lowest %SH and ΔKHN among all groups (p < 0.001). The addition of HMPnano to 1100F significantly increased Ca concentrations (p < 0.001). The 1100F/HMPnano promoted lower values of EPS when compared with 1100F (~ 70%) (p < 0.001) and higher values of fluoride and calcium in the biofilms (p < 0.001).

Conclusion

1100F/HMPnano demonstrated a greater protective effect against enamel demineralization and on the composition of biofilm in situ when compared to 1100F toothpaste.

Clinical relevance

This toothpaste could be a viable alternative to patients at high risk of caries.

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Titel: Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate
verfasst von: Luhana Santos Gonzales Garcia
Alberto Carlos Botazzo Delbem
Juliano Pelim Pessan
Matheus dos Passos Silva
Francisco Nunes Souza Neto
Luiz Fernando Gorup
Emerson Rodrigues de Camargo
Marcelle Danelon
Publikationsdatum: 11.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 9/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2773-7

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Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate

Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

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Abstract

Objective

Methods

Results

Conclusion

Clinical relevance

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