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27.02.2020 | Review

Antigen-presenting cells in ocular surface diseases

verfasst von: Dimitrios Kalogeropoulos, Alexandra Papoudou-Bai, Mark Lane, Anna Goussia, Antonia Charchanti, Marilita M. Moschos, Panagiotis Kanavaros, Chris Kalogeropoulos

Erschienen in: International Ophthalmology | Ausgabe 6/2020

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Abstract

Purpose

To review the role of antigen-presenting cells (APC) in the pathogenesis of ocular surface diseases (OSD).

Methods

A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items.

Results

APCs have the ability to initiate and direct immune responses and are found in most lymphoid and non-lymphoid tissues. APCs continuously sample their environment, present antigens to T cells and co-ordinate immune tolerance and responses. Many different types of APCs have been described and there is growing evidence that these cells are involved in the pathogenesis of OSD. OSD is a complex term for a myriad of disorders that are often characterized by ocular surface inflammation, tear film instability and impairment of vision.

Conclusions

This review summarizes the current knowledge concerning the immunotopographical distribution of APCs in the normal ocular surface. APCs appear to play a critical role in the pathology of a number of conditions associated with OSD including infectious keratitis, ocular allergy, dry eye disease and pterygium.

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Titel: Antigen-presenting cells in ocular surface diseases
verfasst von: Dimitrios Kalogeropoulos
Alexandra Papoudou-Bai
Mark Lane
Anna Goussia
Antonia Charchanti
Marilita M. Moschos
Panagiotis Kanavaros
Chris Kalogeropoulos
Publikationsdatum: 27.02.2020
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 6/2020
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01329-0

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Antigen-presenting cells in ocular surface diseases

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