Nguyen Van Cuong and Nguyen Thi Nhung have equally contributed to this work.
Antimicrobials are extensively used as growth promoters in animal feeds worldwide, but reliable estimates are lacking. We conducted an internet-based survey of commercial chicken and pig feed products officially approved for sale in Vietnam over the period March–June 2015. Information on the antimicrobial contents in feed products, alongside animal production data, was used to estimate in-feed antimicrobial consumption to produce one kilogram of live animal (chicken, pig), as well as to estimate country-wide antimicrobial consumption through animal feeds. A total of 1462 commercial feed formulations were examined. The survey-adjusted estimated antimicrobial contents were 25.7 and 62.3 mg/kg in chicken and pig feeds, respectively. Overall, it was estimated that 77.4 mg [95% CI 48.1–106.8] and 286.6 mg [95% CI 191.6–418.3] of in-feed antimicrobials were used to raise 1 kg of live chicken and pig, respectively. Bacitracin (15.5% feeds), chlortetracycline (11.4%), and enramycin (10.8%) were the most common antimicrobials present in chicken feed formulations, whereas bacitracin (24.8%), chlortetracycline (23.9%), and florfenicol (17.4%) were the most common in pig feed formulations. Overall, 57% of the total quantitative usage consisted of antimicrobials regarded by WHO of importance for human medicine, including amoxicillin, colistin, tetracyclines, neomycin, lincomycin, and bacitracin. These figures confirm a very high magnitude of in-feed consumption of antimicrobials, especially in pig production. Results from this study should encourage further monitoring of antimicrobials used in animal production, and foster discussion about existing policies on inclusion of antimicrobials in animal feed rations.
Aarestrup FM, and Carstensen B (1998). Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant Enterococci and Staphylococci in pigs. Microbial Drug Resistance-Mechanisms Epidemiology and Disease 4:307-312. CrossRef
Callaway TR, Edrington TS, Rychlik JL, Genovese KJ, Poole TL, Jung YS, et al. (2013). Ionophores: their use as ruminant growth promotants and impact on food safety. Curr Issues Intest Microbiol 4:43-51.
Carrique-Mas J, Trung NV, Hoa NT, Mai HH, Thanh TT, Campbell J, et al. (2014). Antimicrobial usage in chicken production in the Mekong delta of Vietnam. Zoonoses Public Health 61 (Suppl. 2):1-9.
Dang PK, Saegerman C, Douny C, Ton VD, Bo HX, Binh DV, et al. (2013). First Survey on the Use of Antibiotics in Pig and Poultry Production in the Red River Delta Region of Vietnam. Food and Public Health 3:247-256.
Desvaux S, Ton VD (2008). A general review and a description of poultry production in Vietnam. Available: http://avian-influenza.cirad.fr/training_publications/publications/poultry_production_in_vietnam_cirad_prise_cirrd_niah_jan_2008 [accessed 12 Apr 2015].
Dohoo I, Martyn W, and Stryhn H (2003). Veterinary Epidemiologic Research. AVC Inc., Charlottetown, Canada.
FAO (2008). Poultry production systems in Vietnam. GCP/RAS/228/GER Working Paper No. 4. Available: http://www.fao.org/docrep/013/al693e/al693e00.pdf (accessed 19 April 2015).
FAO (2014). Review of the literature on antimicrobial resistance in zoonotic bacteria from livestock in East, South and Southeast Asia. Available: http://cdn.aphca.org/dmdocuments/REP_AMR_141022_c.pdf [accessed Sep 19, 2015].
FAO (2015). Food supply statistics—food and agriculture organization of the United Nations (Statistics Division). Available: http://www.fao.org/statistics/en/ [accessed Jul 30, 2015].
General Statistics Office (GSO) (2015). Statistics yearbook, Vietnam 2013. Available: http://www.gso.gov.vn/default_en.aspx?tabid=515&idmid=5&ItemID=14079 [accessed 12 April 2015].
Kinh LV, Hai LT. (2007). Improving pig performance through breeding and feeding in Vietnam. In: Pig systems in Asia and the Pacific: How can research and development enhance benefits to the poor? ILRI, 23–24 November 2006, Bangkok, Thailand. Available: http://www.ilri.org/InfoServ/Webpub/fulldocs/Pig%20Systems_proceeding/CH_08_Kinh_Hai.pdf [accessed 21 April 2015].
Laxminarayan R, Boeckel T, and Teillant A (2015). The economic costs of withdrawing antimicrobial growth promoters from the livestock Sector. OECD Food, Agriculture and Fisheries Papers. OECD Food, Agriculture and Fisheries Papers, No. 78, OECD Publishing. Available: http://dx.doi.org/10.1787/5js64kst5wvl-en [accessed 27 July 2015].
Le Minh V, Khanh Nhu NT, Vinh Phat V, Thompson C, Huong Lan NP, Thieu Nga TV, et al. (2015). The in vitro activity of colistin in antimicrobial combination against carbapenem resistant Acinetobacter baumannii isolated from patients with ventilator associated pneumonia in Vietnam. J Med Microbiol. 2015 DOI: 10.1099/jmm.0.000137. [Online July 17, 2015].
Liu Y, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH and Shen J (2016). Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis16: 161–168. CrossRefPubMed
Lumley T (2004) Analysis of complex survey samples. Journal of Statistical Software 9: 1-19. CrossRef
Malhotra-Kumar S, Xavier BB, Das AJ, Lammens C, Hoang HT, Pham NT, Goossens H (2016). Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam. Lancet Infect Dis. 2016 DOI [Online Jan 7 2016].
MARD (Ministry of Agriculture and Development, Government of Vietnam) (2012). Circular 26/2012/TT-BNNPTNT. Promulgation of the provisional list of livestock and poultry feeds authorised in Việt Nam [in Vietnamese]. Available: http://chicucthuyhcm.org.vn/Luat/26-2012-TT-BNNPTNT.aspx [accessed 7 March 2013].
MARD (Ministry of Agriculture and Development, Government of Vietnam) (2014). Circular 28/2014/TT-BNN Promulgation of the list of chemicals, antibiotics prohibited from importation, production, trade and use in livestock and poultry feeds in Vietnam. Available: http://tailieu.vn/doc/thong-tu-so-28-2014-tt-bnnptnt-1727942.html [accessed 27 March 2015].
Nhung NT, Cuong NV, Hoang NVM, Campbell J, Hoa NT, Bryant JE, et al. (2014). High levels of antimicrobial resistance among Escherichia coli isolates from livestock farms and synanthropic rats and shrews in the Mekong Delta of Vietnam. Appl Environ Microbiol 81(3):1-9.
Otte J, Pfeiffer D, and Rushton J (2012). Antimicrobial use in livestock production and antimicrobial resistance in the Asia-Pacific region. Available: http://cdn.aphca.org/dmdocuments/RBR_1210_APHCA%20AMR.pdf [accessed 24 September 2015].
Page SW, and Gautier P (2012). Use of antimicrobial agents in livestock. Rev Sci Tech 31:145-188.
Selvin S (1998). Modern applied biostatistical methods using S-Plus. Oxford University Press, New York.
Skov RL and Monnet DL (2016). Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Eurosurveillance 21(9): 30155. CrossRef
Tu LPT, Hoang NV, Cuong NV, Campbell J, J.E. B, Hoa NT, et al. (2015). High levels of contamination and antimicrobial resistant non-typhoidal Salmonella serovars on pig and poultry farms in the Mekong Delta of Vietnam. Epidemiol Infect. 143:3074-86. DOI: 10.1017/S0950268815000102. CrossRefPubMedPubMedCentral
Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP, et al. (2015). Global trends in antimicrobial use in food animals. PNAS:5649–5654.
WHO (2011). Critically important antimicrobials for human medicine (third revision). Availalble: http://www.who.int/foodsafety/publications/antimicrobials-third/en/ [accessed 15 Apr 2015].
WHO (2014). Antimicrobial Resistance: Global Report on surveillance. Available: http://www.who.int/drugresistance/documents/surveillancereport/en/ [accessed 1 July 2015].
- Antimicrobial Consumption in Medicated Feeds in Vietnamese Pig and Poultry Production
Nguyen Van Cuong
Nguyen Thi Nhung
Nguyen Huu Nghia
Nguyen Thi Mai Hoa
Nguyen Vinh Trung
- Springer US