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03.11.2018 | Original Article

Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

verfasst von: Mariana Sales de Melo Soares, Cristine D’Almeida Borges, Marcos de Mendonça Invernici, Fabiani Gai Frantz, Luciene Cristina de Figueiredo, Sérgio Luis Scombatti de Souza, Mario Taba Jr., Michel Reis Messora, Arthur Belém Novaes Jr

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2019

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Abstract

Objectives

This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis.

Materials and methods

Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Root Planing (SRP) or SRP. aPDT was performed by using a laser light source with 660 nm wavelength associated with a photosensitizer. The applications were performed in four episodes (at days 0, 2, 7, and 14). All patients were monitored for 90 days. Plaque index, probing depth, clinical attachment level, and bleeding on probing were performed at baseline, 30, and 90 days after the SRP. Gingival crevicular fluid and subgingival plaque samples were collected for immunological and microbiological analysis, respectively. Data obtained were statistically analyzed.

Results

aPDT as an adjunct to SRP did not demonstrate statistically significant advantages on clinical parameters when compared with SRP alone. No statistic significant differences between groups were observed (p < 0.05). Levels of anti-inflammatory cytokines and bacterial species were comparable in both groups at day 90 after treatment.

Conclusion

Periodontal treatment with SRP + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis.

Clinical relevance

Multiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis. ClinicalTrials.gov Identifier: NCT03039244

Phenothiazine chloride, 10 mg/Ml, HELBO Blue, HELBO Photodynamic Systems, Grieskirchen, Austria

Minilaser 2075F, Helbo Photodynamic Systems

HELBO 3D Pocket Probe, HELBO Photodynamic Systems

Florida Probe, Gainesville, FL

PerioPapers, Interstate Drug Exchange, Amityville, NY

MilliplexMap, Merck Millipore, Billerica, MA

MAGPIX analyzer, Luminex, Austin, TX

Salimetrics Inc., State College, PA, USA

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Titel: Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial
verfasst von: Mariana Sales de Melo Soares
Cristine D’Almeida Borges
Marcos de Mendonça Invernici
Fabiani Gai Frantz
Luciene Cristina de Figueiredo
Sérgio Luis Scombatti de Souza
Mario Taba Jr.
Michel Reis Messora
Arthur Belém Novaes Jr
Publikationsdatum: 03.11.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2740-3

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Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial

Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objectives

Materials and methods

Results

Conclusion

Clinical relevance

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