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Erschienen in: Der Anaesthesist 3/2012

01.03.2012 | Klinische Pharmakologie

Antimikrobielle Therapie bei Patienten nach Verbrennungstrauma

verfasst von: T. Trupkovic, J. Gille, H. Fischer, Prof. Dr. S. Kleinschmidt

Erschienen in: Die Anaesthesiologie | Ausgabe 3/2012

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Zusammenfassung

Patienten mit schweren Verbrennungstraumen sind u. a. durch infektiöse Komplikationen gefährdet. Eine Hauptgefahr stellt die Infektion mit multiresistenten bakteriellen Erregern dar; Pilz- und virale Infektionen erhöhen das Mortalitätsrisiko zusätzlich. Neben profunden Kenntnissen über die besondere Infektionsgefährdung in dieser speziellen Patientenpopulation sowie über die frühzeitige Diagnose und Einleitung einer adäquaten Therapie sind auch Kenntnisse über die Änderung pharmakokinetischer und pharmakodynamischer Parameter der einzelnen antimikrobiellen Substanzen von Bedeutung. Diese sind u. a. in der Veränderung der Flüssigkeitskompartimente, der Albuminkonzentration und der freien Fraktion der Substanzen begründet. Die vorliegende Übersicht fasst die bisherigen Erkenntnisse zusammen und gibt eine Handlungsanweisung für die praktische Durchführung der antimikrobiellen Therapie bei Verbrennungspatienten.
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Metadaten
Titel
Antimikrobielle Therapie bei Patienten nach Verbrennungstrauma
verfasst von
T. Trupkovic
J. Gille
H. Fischer
Prof. Dr. S. Kleinschmidt
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Die Anaesthesiologie / Ausgabe 3/2012
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI
https://doi.org/10.1007/s00101-012-1994-4

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