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International Urogynecology Journal
Erschienen in: International Urogynecology Journal 8/2011

01.08.2011 | Review Article

Antimuscarinics for the treatment of overactive bladder: understanding the role of muscarinic subtype selectivity

verfasst von: Karin Glavind, Michael Chancellor

Erschienen in: International Urogynecology Journal | Ausgabe 8/2011

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Abstract

Introduction and hypothesis

Antimuscarinic agents appear to exert their therapeutic activity in overactive bladder (OAB) via blockade of the M3 muscarinic receptor subtype. Antimuscarinics are broadly similar in efficacy, but their safety and tolerability profiles vary, which may reflect differences in muscarinic receptor selectivity profiles.

Methods

This review of available literature aims to determine whether antimuscarinic agents with greater M3 selectivity have clinical advantages over less selective drugs.

Results

Antimuscarinic agents differ widely in their propensity to cause cognitive and cardiovascular (CV) effects, which appear mainly to be related to differences in their relative selectivity for binding to non-M3 receptors, including M1 receptors in the brain and cardiac M2 receptors.

Conclusions

Cognitive and CV effects are especially pertinent for the OAB patient who tends to be older with various comorbidities and is often taking multiple medications. Hence, it is important to consider the risk/benefit balance of antimuscarinic agents when selecting OAB treatment.
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Metadaten
Titel
Antimuscarinics for the treatment of overactive bladder: understanding the role of muscarinic subtype selectivity
verfasst von
Karin Glavind
Michael Chancellor
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 8/2011
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-011-1411-6

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