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24.04.2024 | Observational Research

Antineutrophil cytoplasmic antibody positivity incidence before and during COVID-19 pandemic

verfasst von: Perković Dijana, Petrić Marin, Petra Šimac, Vodanović Ana, Borić Katarina, Gugo Katarina, Tandara Leida

Erschienen in: Rheumatology International | Ausgabe 10/2024

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There are many factors associated with the development of autoimmune diseases. It is known that viral infections can be the triggers of these diseases [1, 2]. Since the end of 2019, the world has been faced with the global COVID19 pandemic caused by coronavirus 2 (SARS-CoV-2). As knowledge about the virus and its broad pathogenetic potential increased, evidence emerged of the development of various autoantibodies and autoimmune diseases following COVID19 infections [3‐5]. COVID-19 was associated with a polyclonal autoreactive B cell activation reflected by an increased number of plasma autoantibody levels [3]. Molecular mimicry together with hyperactivity of the host’s immune system during the infection of COVID19 are some of the possible mechanisms for the induction of autoimmunity [6]. One of the important features of the COVID-19 infection is elevated neutrophil-to-lymphocyte ratio and elevated neutrophil extracellular trap (NET) circulation. NETs, on the other hand, can further activate complement pathways causing tissue destruction and vasculitis [7]. …

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Titel: Antineutrophil cytoplasmic antibody positivity incidence before and during COVID-19 pandemic
verfasst von: Perković Dijana
Petrić Marin
Petra Šimac
Vodanović Ana
Borić Katarina
Gugo Katarina
Tandara Leida
Publikationsdatum: 24.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 10/2024
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-024-05596-3

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