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Comparative Clinical Pathology

Erschienen in:

20.12.2016 | Original Article

Antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi

verfasst von: Antoni Pardede, Mamoru Koketsu

Erschienen in: Comparative Clinical Pathology | Ausgabe 3/2017

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Abstract

In this study, antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi was investigated. Research findings have shown that several extracts of M. casturi have potent bioactivity. The methanol extract of M. casturi bark was partitioned successively to yield n-hexane fraction (6.7%), ethyl acetate (EtOAc) fraction (24.1%), and n-butanol (n-BuOH) fraction (28.1%). Five compounds were isolated from EtOAc fraction and one compound was isolated from n-hexane fraction. These compounds were identified as methyl gallate (1), taxifolin (2), pyrocatechuic acid (3), gallic acid (4), glucogallin (5), and β-sitosterol (6), respectively; they were confirmed by spectroscopic analysis and ultra-performance liquid chromatography-mass spectrometry. All compounds were isolated from bark of M. casturi for the first time. The EtOAc fraction as well as the isolated gallic acid (4) showed potent antioxidative and antileukemic activity against human leukemia HL-60 cells.

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Titel: Antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi
verfasst von: Antoni Pardede
Mamoru Koketsu
Publikationsdatum: 20.12.2016
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 3/2017
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-016-2387-x

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