Background
Methods
Subjects
Procedure
Neurocognitive assessment
Genotyping
Statistical analysis
Power analysis
Results
Subjects
Met/Met (N = 12; 92 obs.) | Val/Met + Val/Val (N = 39; 355 obs.) | |||
---|---|---|---|---|
Mean | SD | Mean | SD | |
Gender M/F | 7/5 | 20/19 | ||
Age | 45.5 | 8.7 | 46.5 | 6.8 |
Education | 4.6 | 2.4 | 5.5 | 2.2 |
BPRS1
| 1.3 | 0.2 | 1.3 | 0.2 |
HDRS2
| 2.9 | 3.6 | 3.3 | 3.9 |
YMRS3
| 2.1 | 3.2 | 1.1 | 2.3 |
GIT-IQ | 101.7 | 9.7 | 110.5 | 13.3 |
Verbal memory | 7.2 | 2.4 | 8.2 | 3.7 |
Selective attention | 729.5 | 77.4 | 687.6 | 81.9 |
Working memory | 5.7 | 1.6 | 6.9 | 2.1 |
Antipsychotic use | 5 | 8 |
Genotype
Cognitive data
Cognitive | Variable | Verbal | Memory | Selective | Attention | Working | Memory | Composite | Measure |
---|---|---|---|---|---|---|---|---|---|
N obs. | 419 | 384 | 416 | 379 | |||||
beta
|
p-value
|
beta
|
p-value
|
beta
|
p-value
|
beta
|
p-value
| ||
COMT | 0.24 | 0.511 | 0.63 | 0.053 | 0.5 | 0.051 | 0.42 | 0.036 | |
Antipsych. | −0.03 | 0.932 | 0.64 | 0.087 | 0.05 | 0.858 | 0.19 | 0.367 | |
MainInteract. | −0.79 | 0.091 | −1.1 | 0.024 | −0.35 | 0.340 | −0.79 | 0.004 | |
Stratified | COMT = 0 | 0.64 | 0.087 | 0.19 | 0.367 | ||||
interaction | COMT = 1 | −0.47 | 0.141 | −0.59 | 0.001 | ||||
BPRS | −0.05 | 0.492 | −0.02 | 0.835 | −0.05 | 0.396 | −0.04 | 0.385 | |
HDRS | 0.005 | 0.948 | 0.05 | 0.551 | 0.06 | 0.292 | 0.02 | 0.602 | |
YMRS | 0.002 | 0.972 | 0.12 | 0.029 | 0.07 | 0.061 | 0.06 | 0.063 | |
Time | 0.06 | 0.000 | 0.13 | 0.000 | 0.09 | 0.000 | 0.09 | 0.000 |