The authors declare that they have no competing interests.
LBE - data collection, statistical analysis and interpretation of the data, drafting of the article. KS – statistical analysis and interpretation of the data, critical review of the article. ABB – initial planning of the study in collaboration with the TIDES group, design, data collection, critical review of the article. LH – initial planning of the study, critically reviewing of the article. BM – planning of the study concept, drafting/critical review of the article, PI . All authors critically read and commented on the manuscript. All authors read and approved the final manuscript.
LBE – Clinical Psychologist, Stockholm CF-center, Karolinska University Hospital
PhD Student, Division of Psychology, Karolinska Institutet
KS - PhD, Division of Psychology, Karolinska Institutet, Sweden
ABB – Clinical Psychologist, Stockholm CF-center, Karolinska University Hospital, Associate Professor
LH – Med Dr, Director of Stockholm CF-center and the Department of Pediatric Pulmonology and Allergy, Karolinska University Hospital
Professor, Division of Pediatrics, Karolinska Institutet
BM – Professor, Division of Psychology, Karolinska Institutet
Cystic fibrosis (CF) is the most common autosomal recessive life-shortening disease among Caucasians. Studies exploring the prevalence of anxiety and depression in adult CF patients are few, show inconsistent findings and rarely include comparisons with general populations. Prevalence and degree of anxiety and depression were investigated in adult CF patients in Sweden, Belgium, Germany and the UK, and compared to corresponding general population data.
Adult non-transplanted CF patients from the three largest CF-centres (out of four) in Sweden (N = 129; Age range 18–70 years; 50 % women) completed the Hospital Anxiety and Depression Scale (HADS). Studies using HADS in adult CF populations in the UK, Germany, and Belgium were included, as well as HADS normative data from the corresponding general populations.
No elevated risk for anxiety and depression was found among the CF patients. However, a Country x Group interaction effect emerged; CF patients experienced a higher degree of anxiety than the general population in Sweden, but not in the other countries, though this finding did not remain significant in a logistic regression analysis. In Sweden the effect was limited to women. A Country x Group interaction effect was also found for Depression; CF patients experienced lower degree of depression than the general population in Sweden, Germany and the UK, but not in Belgium/Netherlands.
Contrary to earlier outcomes, the present results do not indicate any general elevated risk for anxiety and depression among CF patients. Anxiety was slightly higher in the Swedish CF population, compared to the general population; this finding was not seen in the other countries. Depression among CF patients was lower than or similar to that in the general populations in the studied countries.
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- Anxiety and depression in adults with cystic fibrosis: a comparison between patients and the general population in Sweden and three other European countries
- BioMed Central
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