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Erschienen in: Tumor Biology 2/2016

08.09.2015 | Original Article

Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells

verfasst von: Fangyuan Nie, Yan Liang, Bing Jiang, Xiabing Li, Hang Xun, Wei He, Hay Tong Lau, Xiaofeng Ma

Erschienen in: Tumor Biology | Ausgabe 2/2016

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Abstract

Breast cancer is one of the most common cancers and is the second leading cause of cancer mortality in women worldwide. Novel therapies and chemo-therapeutic drugs are urgently needed to be developed for the treatment of breast cancer. Increasing evidence suggests that fatty acid synthase (FAS) plays an important role in breast cancer, for the expression of FAS is significantly higher in human breast cancer cells than in normal cells. Tannic acid (TA), a natural polyphenol, possesses significant biological functions, including bacteriostasis, hemostasis, and anti-oxidant. Our previous studies demonstrated that TA is a natural FAS inhibitor whose inhibitory activity is stronger than that of classical FAS inhibitors, such as C75 and cerulenin. This study further assessed the effect and therapeutic potential of TA on FAS over-expressed breast cancer cells, and as a result, TA had been proven to possess the functions of inhibiting intracellular FAS activity, down-regulating FAS expression in human breast cancer MDA-MB-231 and MCF-7 cells, and inducing cancer cell apoptosis. Since high-expressed FAS is recognized as a molecular marker for breast cancer and plays an important role in cancer prognosis, these findings suggest that TA is a potential drug candidate for treatment of breast cancer.
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Metadaten
Titel
Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells
verfasst von
Fangyuan Nie
Yan Liang
Bing Jiang
Xiabing Li
Hang Xun
Wei He
Hay Tong Lau
Xiaofeng Ma
Publikationsdatum
08.09.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 2/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4020-z

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