Erschienen in:

03.07.2024 | Research

Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results

verfasst von: Jie Zhou, Wenbo Sun, Huan Li, Xiaopeng Song, Dan Xu, Haibo Xu

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2024

Abstract

Purpose

Glutamate chemical exchange saturation transfer (GluCEST) is a non-invasive CEST imaging technique for detecting glutamate levels in tissues. We aimed to investigate the reproducibility of the 5T GluCEST technique in healthy volunteers and preliminarily explore its potential clinical application in patients with brain tumors.

Methods

Ten volunteers (4 males, mean age 29 years) underwent three 5T GluCEST imaging scans. The reproducibility of the three imaging GluCEST measurements was assessed using one-way repeated measures analysis of variance (ANOVA), generalized estimating equations, and linear mixed models. Twenty-eight patients with brain tumors (10 males, mean age 54 years) underwent a single GluCEST scan preoperatively, and t-tests were used to compare the differences in GluCEST values between different brain tumors. In addition, the diagnostic accuracy of GluCEST values in differentiating brain tumors was assessed using the receiver work characteristics (ROC) curve.

Results

The coefficients of variation of GluCEST values in healthy volunteers were less than 5% for intra-day, inter-day, and within-subjects and less than 10% for between-subjects. High-grade gliomas (HGG) had higher GluCEST values compared to low-grade gliomas (LGG) (P < 0.001). In addition, cerebellopontine angle (CPA) meningiomas had higher GluCEST values than acoustic neuromas (P < 0.001). The area under the curve (AUC) of the GluCEST value for differentiating CPA meningioma from acoustic neuroma was 0.93.

Conclusion

5T GluCEST images are highly reproducible in healthy brains. In addition, the 5T GluCEST technique has potential clinical applications in differentiating LGG from HGG and CPA meningiomas from acoustic neuromas.

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Titel: Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results
verfasst von: Jie Zhou
Wenbo Sun
Huan Li
Xiaopeng Song
Dan Xu
Haibo Xu
Publikationsdatum: 03.07.2024
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2024
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-024-04759-3

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Application of 5T glutamate chemical exchange saturation transfer imaging in brain tumors: preliminary results

Abstract

Purpose

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