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Erschienen in: Journal of Cancer Research and Clinical Oncology 11/2010

01.11.2010 | Original Paper

Application of MALDI imaging for the diagnosis of classical Hodgkin lymphoma

verfasst von: Kristina Schwamborn, René C. Krieg, Peggy Jirak, German Ott, Ruth Knüchel, Andreas Rosenwald, Axel Wellmann

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 11/2010

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Abstract

Hodgkin lymphoma (HL) is a distinctive lymphoma subtype characterized by rareness of tumor cells [Hodgkin’s and Reed-Sternberg (HRS) cells in classical HL and lymphocytic and histiocytic cells in lymphocyte predominant HL] as well as the vast majority of the surrounding inflammatory-like cellular infiltrate. Still the onset of this highly variable disease is not completely understood. Proteome analysis can lead to the identification of potential proteins capable of elucidating malignant growth and survival in HL. Especially MALDI imaging could result in pinpointing differentially expressed proteins, which might represent potential marker molecules. In this study, we were able to distinguish between classical Hodgkin lymphoma and lymphadenitis with a sensitivity and specificity of 83.92 and 89.37%, respectively.
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Metadaten
Titel
Application of MALDI imaging for the diagnosis of classical Hodgkin lymphoma
verfasst von
Kristina Schwamborn
René C. Krieg
Peggy Jirak
German Ott
Ruth Knüchel
Andreas Rosenwald
Axel Wellmann
Publikationsdatum
01.11.2010
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 11/2010
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-010-0823-x

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