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Erschienen in:

15.09.2020 | Guidelines and position papers

Approaching acute pain in emergency settings; European Society for Emergency Medicine (EUSEM) guidelines—part 2: management and recommendations

verfasst von: Saïd Hachimi-Idrissi, Viliam Dobias, Wolf E. Hautz, Robert Leach, Thomas C. Sauter, Idanna Sforzi, Frank Coffey

Erschienen in: Internal and Emergency Medicine | Ausgabe 7/2020

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Abstract

Background

In Europe, healthcare systems and education, as well as the clinical care and health outcomes of patients, varies across countries. Likewise, the management of acute events for patients also differs, dependent on the emergency care setting, e.g. pre-hospital or emergency department. There are various barriers to adequate pain management and factors common to both settings including lack of knowledge and training, reluctance to give opioids, and concerns about drug-seeking behaviour or abuse. There is no single current standard of care for the treatment of pain in an emergency, with management based on severity of pain, injury and local protocols. Changing practices, attitudes and behaviour can be difficult, and improvements and interventions should be developed with barriers to pain management and the needs of the individual emergency setting in mind.

Methods

With these principles at the forefront, The European Society for Emergency Medicine (EUSEM) launched a programme—the European Pain Initiative (EPI)—with the aim of providing information, advice, and guidance on acute pain management in emergency settings.

Results and conclusions

This article provides treatment recommendations from recently developed guidelines, based on a review of the literature, current practice across Europe and the clinical expertise of the EPI advisors. The recommendations have been developed, evaluated, and refined for both adults and children (aged ≥ 1 year, ≤ 15 years), with the assumption of timely pain assessment and reassessment and the possibility to implement analgesia. To provide flexibility for use across Europe, options are provided for selection of appropriate pharmacological treatment.

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Berben SA, Meijs TH, van Dongen RT, van Vugt AB, Vloet LC, Mintjes-de Groot JJ, van Achterberg T (2008) Pain prevalence and pain relief in trauma patients in the Accident & Emergency department. Injury 39(5):578–585. https://doi.org/10.1016/j.injury.2007.04.013PubMedCrossRef

Gueant S, Taleb A, Borel-Kuhner J, Cauterman M, Raphael M, Nathan G, Ricard-Hibon A (2011) Quality of pain management in the emergency department: results of a multicentre prospective study. Eur J Anaesthesiol 28(2):97–105. https://doi.org/10.1097/EJA.0b013e3283418fb0PubMedCrossRef

Albrecht E, Taffe P, Yersin B, Schoettker P, Decosterd I, Hugli O (2013) Undertreatment of acute pain (oligoanalgesia) and medical practice variation in prehospital analgesia of adult trauma patients: a 10 yr retrospective study. Br J Anaesth 110(1):96–106. https://doi.org/10.1093/bja/aes355PubMedCrossRef

Mills AM, Shofer FS, Chen EH, Hollander JE, Pines JM (2009) The association between emergency department crowding and analgesia administration in acute abdominal pain patients. Acad Emerg Med 16(7):603–608. https://doi.org/10.1111/j.1553-2712.2009.00441.xPubMedCrossRef

De Berardinis B, Magrini L, Calcinaro S, Castello LM, Avanzi GC, Semplicini A, Alzetta M, Giordano B, Di Somma S (2013) Emergency department pain management and its impact on patients' short term outcome. Open Emerg Med J 5:1–7CrossRef

Hachimi-Idrissi S, Coffey F, Hautz WE, LEach R, Sauter TC, Sforzi I, Dobias W (2020) Approaching acute pain in emergency settings; European Society of Emergency Medicine (EUSEM) guidelines—part 1: assessment (to be completed)

Whittemore R, Knafl K (2005) The integrative review: updated methodology. J Adv Nurs 52(5):546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.xPubMedCrossRef

Ahmadi A, Bazargan-Hejazi S, Heidari Zadie Z, Euasobhon P, Ketumarn P, Karbasfrushan A, Amini-Saman J, Mohammadi R (2016) Pain management in trauma: a review study. J Inj Violence Res 8(2):89–98. https://doi.org/10.5249/jivr.v8i2.707PubMedPubMedCentralCrossRef

Powell R, Scott NW, Manyande A, Bruce J, Vogele C, Byrne-Davis LM, Unsworth M, Osmer C, Johnston M (2016) Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia. Cochrane Database Syst Rev 5:CD008646. https://doi.org/10.1002/14651858.CD008646.pub2CrossRef

10.

Suls J, Wan CK (1989) Effects of sensory and procedural information on coping with stressful medical procedures and pain: a meta-analysis. J Consult Clin Psychol 57(3):372–379PubMedCrossRef

11.

Good M, Albert JM, Anderson GC, Wotman S, Cong X, Lane D, Ahn S (2010) Supplementing relaxation and music for pain after surgery. Nurs Res 59(4):259–269. https://doi.org/10.1097/NNR.0b013e3181dbb2b3PubMedCrossRef

12.

Kwekkeboom KL, Gretarsdottir E (2006) Systematic review of relaxation interventions for pain. J Nurs Scholarsh 38(3):269–277PubMedCrossRef

13.

Lim YC, Yobas P, Chen HC (2014) Efficacy of relaxation intervention on pain, self-efficacy, and stress-related variables in patients following total knee replacement surgery. Pain Manag Nurs 15(4):888–896. https://doi.org/10.1016/j.pmn.2014.02.001PubMedCrossRef

14.

Lin PC (2012) An evaluation of the effectiveness of relaxation therapy for patients receiving joint replacement surgery. J Clin Nurs 21(5–6):601–608. https://doi.org/10.1111/j.1365-2702.2010.03406.xPubMedCrossRef

15.

Nelson K, Adamek M, Kleiber C (2017) Relaxation training and postoperative music therapy for adolescents undergoing spinal fusion surgery. Pain Manag Nurs 18(1):16–23. https://doi.org/10.1016/j.pmn.2016.10.005PubMedCrossRef

16.

Rejeh N, Heravi-Karimooi M, Vaismoradi M, Jasper M (2013) Effect of systematic relaxation techniques on anxiety and pain in older patients undergoing abdominal surgery. Int J Nurs Pract 19(5):462–470. https://doi.org/10.1111/ijn.12088PubMedCrossRef

17.

Schug SA, Palmer GM, Scott DA et al (2015) Acute pain management: scientific evidence, 4th edn. Australian and New Zealand College of Anaesthetists and Faculty of Pain Management, Melbourne

18.

Daake DR, Gueldner SH (1989) Imagery instruction and the control of postsurgical pain. Appl Nurs Res 2(3):114–120PubMedCrossRef

19.

Good M (1995) A comparison of the effects of jaw relaxation and music on postoperative pain. Nurs Res 44(1):52–57PubMedCrossRef

20.

Raft D, Smith RH, Warren N (1986) Selection of imagery in the relief of chronic and acute clinical pain. J Psychosom Res 30(4):481–488PubMedCrossRef

21.

Nilsson U (2008) The anxiety- and pain-reducing effects of music interventions: a systematic review. AORN J 87(4):780–807. https://doi.org/10.1016/j.aorn.2007.09.013PubMedCrossRef

22.

Youn Moon J, Shin J, Chung J, Ji S-H, Ro S, Ho Kim W (2019) Virtual reality distraction during endoscopic urologic surgery under spinal anesthesia: a randomized controlled trial J. Clin Med 8:2. https://doi.org/10.3390/jcm8010002CrossRef

23.

Uman LS, Birnie KA, Noel M, Parker JA, Chambers CT, McGrath PJ, Kisely SR (2013) Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev 10:CD005179. https://doi.org/10.1002/14651858.CD005179.pub3CrossRef

24.

Birnie KA, Noel M, Chambers CT, Uman LS, Parker JA (2018) Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev 10:CD005179. https://doi.org/10.1002/14651858.CD005179.pub4PubMedCrossRef

25.

Wohlheiter KA, Dahlquist LM (2013) Interactive versus passive distraction for acute pain management in young children: the role of selective attention and development. J Pediatr Psychol 38(2):202–212. https://doi.org/10.1093/jpepsy/jss108PubMedCrossRef

26.

Bjordal JM, Johnson MI, Ljunggreen AE (2003) Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain. Eur J Pain 7 (2):181–188. doi:10.1016/S1090–3801(02)00098–8

27.

Johnson MI, Paley CA, Howe TE, Sluka KA (2015) Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev 6:CD006142. https://doi.org/10.1002/14651858.CD006142.pub3CrossRef

28.

Kober A, Scheck T, Greher M, Lieba F, Fleischhackl R, Fleischhackl S, Randunsky F, Hoerauf K (2002) Prehospital analgesia with acupressure in victims of minor trauma: a prospective, randomized, double-blinded trial. Anesth Analg 95(3):723–727PubMed

29.

Kober A, Scheck T, Schubert B, Strasser H, Gustorff B, Bertalanffy P, Wang SM, Kain ZN, Hoerauf K (2003) Auricular acupressure as a treatment for anxiety in prehospital transport settings. Anesthesiology 98(6):1328–1332PubMedCrossRef

30.

Malanga GA, Yan N, Stark J (2015) Mechanisms and efficacy of heat and cold therapies for musculoskeletal injury. Postgrad Med 127(1):57–65. https://doi.org/10.1080/00325481.2015.992719PubMedCrossRef

31.

Bumpass DB, Ricci WM, McAndrew CM, Gardner MJ (2015) A prospective study of pain reduction and knee dysfunction comparing femoral skeletal traction and splinting in adult trauma patients. J Orthop Trauma 29(2):112–118. https://doi.org/10.1097/BOT.0000000000000202PubMedPubMedCentralCrossRef

32.

National Institute for Health and Care Excellence (NICE) (2016) Fractures (non-complex): assessment and management. NICE Guidelines [NG38]. https://www.nice.org.uk/guidance/ng38. Accessed Feb 2020

33.

Siriwardena AN, Asghar Z, Lord B, Pocock H, Phung VH, Foster T, Williams J, Snooks H (2018) Patient and clinician factors associated with prehospital pain treatment and outcomes: cross sectional study. Am J Emerg Med. https://doi.org/10.1016/j.ajem.2018.05.041PubMedCrossRef

34.

McGreevy K, Bottros MM, Raja SN (2011) Preventing chronic pain following acute pain: risk factors, preventive strategies, and their efficacy. Eur J Pain Suppl 5(2):365–372. https://doi.org/10.1016/j.eujps.2011.08.013PubMedPubMedCentralCrossRef

35.

Murphy AP, Hughes M, McCoy S, Crispino G, Wakai A, O'Sullivan R (2017) Intranasal fentanyl for the prehospital management of acute pain in children. Eur J Emerg Med 24(6):450–454. https://doi.org/10.1097/MEJ.0000000000000389PubMedCrossRef

36.

Frey TM, Florin TA, Caruso M, Zhang N, Mittiga MR (2018) Effect of intranasal ketamine vs fentanyl on pain reduction for extremity injuries in children the PRIME randomized clinical trial. JAMA Pediatr 173(2):140–146. https://doi.org/10.1001/jamapediatrics.2018.4582PubMedCentralCrossRef

37.

Schwenk ES, Viscusi ER, Buvanendran A, Hurley RW, Wasan AD, Narouze S, Bhatia A, Davis FN, Hooten WM, Cohen SP (2018) Consensus guidelines on the use of intravenous ketamine infusions for acute pain management from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med 43:456–466PubMedPubMedCentralCrossRef

38.

Coffey F, Wright J, Hartshorn S, Hunt P, Locker T, Mirza K, Dissmann P (2014) STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. Emerg Med J 31(8):613–618. https://doi.org/10.1136/emermed-2013-202909PubMedCrossRef

39.

Ducasse JL, Siksik G, Durand-Bechu M, Couarraze S, Valle B, Lecoules N, Marco P, Lacombe T, Bounes V (2013) Nitrous oxide for early analgesia in the emergency setting: a randomized, double-blind multicenter prehospital trial. Acad Emerg Med 20(2):178–184. https://doi.org/10.1111/acem.12072PubMedCrossRef

40.

Miner JR, Rafique Z, Minkowitz HS, DiDonato KP, Palmer PP (2018) Sufentanil sublingual tablet 30 mcg for moderate-to-severe acute pain in the ED. Am J Emerg Med 36(6):954–961. https://doi.org/10.1016/j.ajem.2017.10.058PubMedCrossRef

41.

World Health Organisation (WHO) Cancer pain ladder. https://www.who.int/cancer/palliative/painladder/en/. Accessed Feb 2020

42.

Thal ER, Montgomery SJ, Atkins JM, Roberts BG (1979) Self-administered analgesia with nitrous oxide. Adjunctive aid for emergency medical care systems. JAMA 242(22):2418–2419PubMedCrossRef

43.

Herres J, Chudnofsky CR, Manur R, Damiron K, Deitch K (2016) The use of inhaled nitrous oxide for analgesia in adult ED patients: a pilot study. Am J Emerg Med 34(2):269–273. 10.1016/j.ajem.2015.10.038

44.

Faddy SC, Garlick SR (2005) A systematic review of the safety of analgesia with 50% nitrous oxide: can lay responders use analgesic gases in the prehospital setting? Emerg Med J 22(12):901–908. https://doi.org/10.1136/emj.2004.020891PubMedPubMedCentralCrossRef

45.

Elia N, Lysakowski C, Tramer MR (2005) Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 103(6):1296–1304PubMedCrossRef

46.

Ridderikhof ML, Lirk P, Goddijn H, Vandewalle E, Schinkel E, Van Dieren S, Kemper EM, Hollmann MW, Goslings JC (2018) Acetaminophen or nonsteroidal anti-inflammatory drugs in acute musculoskeletal trauma: a multicenter, double-blind, randomized, clinical trial. Ann Emerg Med 71(3):357–368. https://doi.org/10.1016/j.annemergmed.2017.08.041PubMedCrossRef

47.

Buccelletti F, Marsiliani D, Zuccala G, Iacomini P, Proietti L, Pola E, Zirio G, Genitiempo M, Marrocco R, Conti C, Brunetti C, Rocchi L, Merendi G, D'Aurizio G, Gilardi E, Franceschi F (2014) Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. Eur Rev Med Pharmacol Sci 18(20):3139–3143PubMed

48.

Bondarsky EE, Domingo AT, Matuza NM, Taylor MB, Thode HC Jr, Singer AJ (2013) Ibuprofen vs acetaminophen vs their combination in the relief of musculoskeletal pain in the ED: a randomized, controlled trial. Am J Emerg Med 31(9):1357–1360. https://doi.org/10.1016/j.ajem.2013.06.007PubMedCrossRef

49.

Lyrtzis C, Natsis K, Papadopoulos C, Noussios G, Papathanasiou E (2011) Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. Foot Ankle Int 32(6):571–575. https://doi.org/10.3113/FAI.2011.0571PubMedCrossRef

50.

Craig M, Jeavons R, Probert J, Benger J (2012) Randomised comparison of intravenous paracetamol and intravenous morphine for acute traumatic limb pain in the emergency department. Emerg Med J 29(1):37–39. https://doi.org/10.1136/emj.2010.104687PubMedCrossRef

51.

Dijkstra BM, Berben SA, van Dongen RT, Schoonhoven L (2014) Review on pharmacological pain management in trauma patients in (pre-hospital) emergency medicine in the Netherlands. Eur J Pain 18(1):3–19. https://doi.org/10.1002/j.1532-2149.2013.00337.xPubMedCrossRef

52.

Westrich GH, Birch GA, Muskat AR, Padgett DE, Goytiozolo EA, Bostrom MP, Mayman DJ, Lin Y, YaDeau JT (2019) Intravenous vs oral acetominophen as a component of multimodal analgesia after total hip arthroplasty: a randomized blinded trial. J Arthroplasty 34(7S):S215–S220PubMedCrossRef

53.

Patel A, Pai BHP, Diskina D, Reardon B, Lai YH (2020) Comparison of clinical outcomes of acetominophen IV vs PO in the peri-operative setting for laproscopic inguinal hernia repair surgeries: a triple-blinded, randomized, controlled trial. J Clin Anesth 61:109628PubMedCrossRef

54.

Jibril F, Sharaby S, Mohamed A, Wilby KJ (2015) Intravenous versus oral acetominophen for pain: systematic review of current evidenc to support clinical decision making. Can J Hosp Pharm 68(3):238–247PubMedPubMedCentral

55.

Furyk J, Levas D, Close B, Laspina K, Fitzpatrick M, Robinson K, Vangaveti VN, Ray R (2018) Intravenous versus oral paracetamol for acute pain in adults in the emergency department setting: a prospective, double-blind, double-dummy, randomised controlled trial. Emerg J Med 35:163–168CrossRef

56.

Thomas SH (2013) Management of pain in the emergency department. ISRN Emerg Med 2013:583132. https://doi.org/10.1155/2013/583132

57.

Savoia G, Coluzzi F, Di Maria C, Ambrosio F, Della Corte F, Oggioni R, Messina A, Costantini A, Launo C, Mattia C, Paoletti F, Lo Presti C, Bertini L, Peduto AV, De Iaco F, Schiraldi F, Bussani F, De Vito L, Giagnorio G, Marinangeli F, Coaccioli S, Aurilio C, Valenti F, Bonetti C, Piroli A, Paladini A, Ciccozzi A, Matarazzo T, Marraro G, Paolicchi A, Martino A, De Blasio E, Cerchiari E, Radeschi G (2015) Italian Intersociety Recommendations on pain management in the emergency setting (SIAARTI, SIMEU, SIS 118, AISD, SIARED, SICUT, IRC). Minerva Anestesiol 81(2):205–225PubMed

58.

Pathan SA, Mitra B, Cameron PA (2018) A systematic review and meta-analysis comparing the efficacy of nonsteroidal anti-inflammatory drugs, opioids, and paracetamol in the treatment of acute renal colic. Eur Urol 73(4):583–595. https://doi.org/10.1016/j.eururo.2017.11.001PubMedCrossRef

59.

Ortiz MI, Monroy-Maya R, Soto-Rios M, Carrillo-Alarcon LC, Ponce-Monter HA, Rangel-Flores E, Loo-Estrada JJ, Izquierdo-Vega JA, Sanchez-Gutierrez M (2010) Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture. Proc West Pharmacol Soc 53:46–48PubMed

60.

Jones P, Dalziel SR, Lamdin R, Miles-Chan JL, Frampton C (2015) Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database System Rev 7:CD007789

61.

Lisowska B, Kosson D, Domaracka K (2018) Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair. Drug Design Devel Ther 12:1809–1814CrossRef

62.

Duchman KR, Lemmex DB, Patel SH, Ledbetter L, Garrigues GE, Riboh JC (2019) The effect of non-steroidal anti-inflammatory drugs on tendon-to-bone healing: a systematic review with subgroup meta-analysis. Iowa Orthop J 39(1):107–119PubMedPubMedCentral

63.

Kuehl K, Carr W, Yanchick J, Magelli M, Rovati S (2011) Analgesic efficacy and safety of the diclofenac epolamine topical patch 1.3% (DETP) in minor soft tissue injury. Int J Sports Med 32(8):635–643. https://doi.org/10.1055/s-0031-1275359PubMedCrossRef

64.

Kuehl KS (2010) Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries. Clin Ther 32(6):1001–1014. https://doi.org/10.1016/j.clinthera.2010.06.001PubMedCrossRef

65.

Lionberger DR, Brennan MJ (2010) Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch. J Pain Res 3:223–233. https://doi.org/10.2147/JPR.S13238PubMedPubMedCentralCrossRef

66.

Mueller EA, Kirch W, Reiter S (2010) Extent and time course of pain intensity upon treatment with a topical diclofenac sodium patch versus placebo in acute traumatic injury based on a validated end point: post hoc analysis of a randomized placebo-controlled trial. Expert Opin Pharmacother 11(4):493–498. https://doi.org/10.1517/14656560903535898PubMedCrossRef

67.

McCarberg BH, Argoff CE (2010) Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury. Int J Clin Pract 64(11):1546–1553. https://doi.org/10.1111/j.1742-1241.2010.02474.xPubMedPubMedCentralCrossRef

68.

Li C, Frangione V, Rovati S, Zheng Q (2013) Diclofenac epolamine medicated plaster in the treatment of minor soft tissue injuries: a multicenter randomized controlled trial. Curr Med Res Opin 29(9):1137–1146. https://doi.org/10.1185/03007995.2013.816669PubMedCrossRef

69.

Costantino C, Kwarecki J, Samokhin AV, Mautone G, Rovati S (2011) Diclofenac epolamine plus heparin plaster versus diclofenac epolamine plaster in mild to moderate ankle sprain: a randomized, double-blind, parallel-group, placebo-controlled, multicentre, phase III trial. Clin Drug Investig 31(1):15–26. https://doi.org/10.2165/11585890-000000000-00000PubMedCrossRef

70.

Predel HG, Giannetti B, Seigfried B, Novellini R, Menke G (2013) A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain. J Int Med Res 41(4):1187–1202. https://doi.org/10.1177/0300060513487639PubMedCrossRef

71.

Predel HG, Hamelsky S, Gold M, Giannetti B (2012) Efficacy and safety of diclofenac diethylamine 2.32% gel in acute ankle sprain. Med Sci Sports Exerc 44(9):1629–1636. https://doi.org/10.1249/MSS.0b013e318257ed41PubMedCrossRef

72.

Lionberger DR, Joussellin E, Lanzarotti A, Yanchick J, Magelli M (2011) Diclofenac epolamine topical patch relieves pain associated with ankle sprain. J Pain Res 4:47–53. https://doi.org/10.2147/JPR.S15380PubMedPubMedCentralCrossRef

73.

Serinken M, Eken C, Elicabuk H (2016) Topical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency department. Foot Ankle Int 37(9):989–993. https://doi.org/10.1177/1071100716650530PubMedCrossRef

74.

Peura DA (2002) Gastrointestinal safety and tolerability of nonselective nonsteroidal anti-inflammatory agents and cyclooxygenase-2-selective inhibitors. Cleve Clin J Med 69(Suppl 1):SI31–39PubMed

75.

Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, Cohen V, Filk N, Smith A, Huang F, Rockoff B, Homel P, Fromm C (2017) Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial. Ann Emerg Med 70(2):177–184. https://doi.org/10.1016/j.annemergmed.2016.10.014PubMedCrossRef

76.

Soleyman-Zomalan E, Motov S, Likourezos A, Cohen V, Pushkar I, Fromm C (2017) Patterns of Ketorolac dosing by emergency physicians. World J Emerg Med 8(1):43–46. https://doi.org/10.5847/wjem.j.1920-8642.2017.01.008PubMedPubMedCentralCrossRef

77.

Salo DF, Lavery R, Varma V, Goldberg J, Shapiro T, Kenwood A (2003) A randomized, clinical trial comparing oral celecoxib 200 mg, celecoxib 400 mg, and ibuprofen 600 mg for acute pain. Acad Emerg Med 10(1):22–30PubMedCrossRef

78.

Glina S, Damiao R, Afif-Abdo J, Santa Maria CF, Novoa R, Cairoli CE, Wajsbrot D, Araya G (2011) Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial. Int Braz J Urol 37(6):697–705PubMedCrossRef

79.

Baharuddin KA, Rahman NH, Wahab SF, Halim NA, Ahmad R (2014) Intravenous parecoxib sodium as an analgesic alternative to morphine in acute trauma pain in the emergency department. Int J Emerg Med 7(1):2. https://doi.org/10.1186/1865-1380-7-2PubMedPubMedCentralCrossRef

80.

Hearn L, Derry S, Moore RA (2016) Single dose dipyrone (metamizole) for acute post-operative pain in adults (Review). Cochrane Database of Systematic Reviews 4(CD011421):1–40

81.

Shah RR (2019) Metamizole (dipyrone)-induced agranulocytosis: does the risk vary according to ethnicity? J Clin Pharm Ther 44(1):129–133. https://doi.org/10.1111/jcpt.12768PubMedCrossRef

82.

Meng W, Yuan J, Zhang C, Bai Z, Zhou W, Yan J, Li X (2013) Parenteral analgesics for pain relief in acute pancreatitis: a systematic review. Pancreatology 13:201–206PubMedCrossRef

83.

Peiro AM, Martinez J, Martinez E, de Madaria E, Llorens P, Horga JF (2008) Efficacy and tolerance of metamizole versus morphine for acute pancreatitis pain. Pancreatology 8:25–29PubMedCrossRef

84.

Sanchez-Carpena J, Dominguez-Hervella F, Garcia I, Gene E, Bugarin R, Martin A, Tomas-Vecina S, Garcia D, Serrano JA, Roman A, Marine M, Mosteiro ML (2007) Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. Eur J Clin Pharmacol 63(8):751–760PubMedCrossRef

85.

Ramacciotti AS, Soares BG, Atallah AN (2007) Dipyrone for acute primary headaches. Cochrane Database Syst Rev 2:CD004842

86.

Kang JH, Oh SY, Song SY, Lee HY, Kim JH, Lee KE, Lee HR, Hwang IG, Park SH, Kim WS, Park YS, Park K (2015) The efficacy of low-dose transdermal fentanyl in opioid-naive cancer patients with moderate-to-severe pain. Korean J Intern Med 30(1):88–95. https://doi.org/10.3904/kjim.2015.30.1.88PubMedCrossRef

87.

Oyler DR, Parli SE, Bernard AC, Chang PK, Procter LD, Harned ME (2015) Nonopioid management of acute pain associated with trauma: focus on pharmacologic options. J Trauma Acute Care Surg 79(3):475–483. https://doi.org/10.1097/TA.0000000000000755PubMedCrossRef

88.

Fortenberry M, Crowder J, So TY (2019) The use of codeine and tramadol in the pediatric population-what is the verdict now? J Paediatr Health Care 33(1):117–123. https://doi.org/10.1016/j.pedhc.2018.04.016CrossRef

89.

Gong L, Stamer UM, Tzetkov MV, Altman RB, Klein TE (2014) PharmGKB summary: tramadol pathway. Pharmacogenet Genomics 24(7):374–380PubMedPubMedCentralCrossRef

90.

Drendel AL, Gorelick MH, Weisman SJ, Lyon R, Brousseau DC, Kim MK (2009) A randomized clinical trial of ibuprofen versus acetominophen with codeine for acute pediatric arm fracture pain. Ann Emerg Med 54(4):553–560PubMedCrossRef

91.

Green SM, Li J (2000) Ketamine in adults: what emergency physicians need to know about patient selection and emergence reactions. Acad Emerg Med 7(3):278–281PubMedCrossRef

92.

Rech MA, Barbas B, Chaney W, Greenhalgh E, Turck C (2017) When to pick the nose: out-of-hospital and emergency department intranasal administration of medications. Ann Emerg Med 70(2):203–211. https://doi.org/10.1016/j.annemergmed.2017.02.015PubMedCrossRef

93.

Miller JP, Schauer SG, Ganem VJ, Bebarta VS (2015) Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial. Am J Emerg Med 33(3):402–408. https://doi.org/10.1016/j.ajem.2014.12.058PubMedCrossRef

94.

Majidinejad S, Esmailian M, Emadi M (2014) Comparison of intravenous ketamine with morphine in pain relief of long bones fractures: a double blind randomized clinical trial. Emerg (Tehran) 2(2):77–80

95.

Jennings PA, Cameron P, Bernard S (2011) Ketamine as an analgesic in the pre-hospital setting: a systematic review. Acta Anaesthesiol Scand 55(6):638–643. https://doi.org/10.1111/j.1399-6576.2011.02446.xPubMedCrossRef

96.

Motov S, Mann S, Drapkin J, Butt M, Likourezos A, Yetter E, Brady J, Rothberger N, Gohel A, Flom P, Mai M, Fromm C, Marshall J (2019) Intravenous subdissociative-dose ketamine versus morphine for acute generatric pain in the Emergency Department: a randomized controlled trial. Am J Emerg Med 37(2):220–227PubMedCrossRef

97.

Parvizrad R, Pakniyat A, Malekianzadeh B, Almasi-Hashiani A (2017) Comparing the analgesic effect of intranasal with intravenous ketamine in isolated orthopedic trauma: a randomized clinical trial. Turk J Emerg Med 17:99–103PubMedPubMedCentralCrossRef

98.

Shimonovich S, Gigi R, Shapira A, Sarig-Meth T, Nadav D, Rozenek M, West D, Halpern P (2016) Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. BMC Emerg Med 16(1):43. https://doi.org/10.1186/s12873-016-0107-0PubMedPubMedCentralCrossRef

99.

Farnia MR, Jalali A, Vahidi E, Momeni M, Seyedhosseini J, Saeedi M (2017) Comparison of intranasal ketamine versus IV morphine in reducing pain in patients with renal colic. Am J Emerg Med 35(3):434–437. https://doi.org/10.1016/j.ajem.2016.11.043PubMedCrossRef

100.

Graudins A, Meek R, Egerton-Warburton D, Oakley E, Seith R (2015) The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: a randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries. Ann Emerg Med 65(3):248–254PubMedCrossRef

101.

Porter KM, Siddiqui MK, Sharma I, Dickerson S, Eberhardt A (2018) Management of trauma pain in the emergency setting: low-dose methoxyflurane or nitrous oxide? A systematic review and indirect treatment comparison. J Pain Res 11:11–21. https://doi.org/10.2147/JPR.S150600PubMedCrossRef

102.

Bendall JC, Simpson PM, Middleton PM (2011) Effectiveness of prehospital morphine, fentanyl, and methoxyflurane in pediatric patients. Prehosp Emerg Care 15(2):158–165. https://doi.org/10.3109/10903127.2010.541980PubMedCrossRef

103.

Galen Limited PENTHROX 99.9%, 3 ml inhalation vapour, liquid summary of product characteristics. November 2018. Available at https://www.medicines.org.uk/emc/medicine/31391 [Accessed February 2020].

104.

Coffey F, Dissmann P, Mirza K, Lomax M (2016) Methoxyflurane analgesia in adult patients in the Emergency Department: a subgroup analysis of a randomized, double-blind, placebo-controlled study (STOP!). Adv Ther 33(11):2012–2031. https://doi.org/10.1007/s12325-016-0405-7PubMedPubMedCentralCrossRef

105.

Johnston S, Wilkes GJ, Thompson JA, Ziman M, Brightwell R (2011) Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. Emerg Med J 28(1):57–63. https://doi.org/10.1136/emj.2009.078717PubMedCrossRef

106.

Borobia AM, Collado SG, Cardona CC, Pueyo RC, Alonso CF, Torres IP, González MC, Casal Codesido JR, Betegón MA, Barcela LA, Andicoechea AO, Testa AF, Colina JT, Dorribo AC, Del Arco GC, Martinez Ávila JC, Lugilde ST, Carcas Sansuán AJ (2020) Inhaled methoxyflurane provides greater analgesia and faster onset of action versus standard analgesia in patients with trauma pain: InMEDIATE: a randomized controlled trial in emergency departments. Ann Emerg Med 75(3):315–328PubMed

107.

Mercadante S, Voza A, Serra S, Ruggiano G, Carpinteri G, Gangitano G, Intelligente F, Bonafede E, Sblendido A, Farina A, Soldi A, Fabbri A (2019) Analgesic efficacy, practicality and safety of inhaled methoxyflurane versus standard analgesic treatment for acute trauma pain in the emergency setting: a randomized, open-label, active-controlled, multicente trial in Italy (MEDITA). Adv Ther 36(11):3030–3046PubMedPubMedCentral

108.

Miller GW, Godrey JJ, Sagmeister ML, Lewis TL (2016) Provision of fascia iliaca compartment block in the acute management of proximal femoral fractures: a national observational study of UK hospitals. Injury 47(11):2490–2494. https://doi.org/10.1016/j.injury.2016.09.003PubMedCrossRef

109.

Abou-Setta AM, Beaupre LA, Rashiq S, Dryden DM, Hamm MP, Sadowski CA, Menon MR, Majumdar SR, Wilson DM, Karkhaneh M, Mousavi SS, Wong K, Tjosvold L, Jones CA (2011) Comparative effectiveness of pain management interventions for hip fracture: a systematic review. Ann Intern Med 155(4):234–245. https://doi.org/10.7326/0003-4819-155-4-201108160-00346PubMedCrossRef

110.

Guay J, Parker MJ, Griffiths R, Kopp S (2017) Peripheral nerve blocks for hip fractures. Cochrane Database Syst Rev 5:CD001159. https://doi.org/10.1002/14651858.CD001159.pub2PubMedCrossRef

111.

Riddell M, Ospina M, Holroyd-Leduc JM (2016) Use of femoral nerve blocks to manage hip fracture pain among older adults in the Emergency Department: a systematic review. CJEM 18(4):245–252. https://doi.org/10.1017/cem.2015.94PubMedCrossRef

112.

Morrison RS, Dickman E, Hwang U, Akhtar S, Ferguson T, Huang J, Jeng CL, Nelson BP, Rosenblatt MA, Silverstein JH, Strayer RJ, Torrillo TM, Todd KH (2016) Regional nerve blocks improve pain and functional outcomes in hip fracture: a randomized controlled trial. J Am Geriatr Soc 64(12):2433–2439. https://doi.org/10.1111/jgs.14386PubMedPubMedCentralCrossRef

113.

Jiang N, Hu YJ, Zhang KR, Zhang S, Bin Y (2014) Intra-articular lidocaine versus intravenous analgesia and sedation for manual closed reduction of acute anterior shoulder dislocation: an updated meta-analysis. J Clin Anesth 26(5):350–359. https://doi.org/10.1016/j.jclinane.2013.12.013PubMedCrossRef

114.

Cheok CY, Mohamad JA, Ahmad TS (2011) Pain relief for reduction of acute anterior shoulder dislocations: a prospective randomized study comparing intravenous sedation with intra-articular lidocaine. J Orthop Trauma 25(1):5–10. https://doi.org/10.1097/BOT.0b013e3181d3d338PubMedCrossRef

115.

Wakai A, O'Sullivan R, McCabe A (2011) Intra-articular lignocaine versus intravenous analgesia with or without sedation for manual reduction of acute anterior shoulder dislocation in adults. Cochrane Database Syst Rev 4:CD004919. https://doi.org/10.1002/14651858.CD004919.pub2CrossRef

116.

Firouzian A, Alipour A, Rashidian Dezfouli H, Zamani Kiasari A, Gholipour Baradari A, Emami Zeydi A, Amini Ahidashti H, Montazami M, Hosseininejad SM, Yazdani Kochuei F (2016) Does lidocaine as an adjuvant to morphine improve pain relief in patients presenting to the ED with acute renal colic? A double-blind, randomized controlled trial. Am J Emerg Med 34(3):443–448. https://doi.org/10.1016/j.ajem.2015.11.062PubMedCrossRef

117.

Soleimanpour H, Hassanzadeh K, Vaezi H, Golzari SE, Esfanjani RM, Soleimanpour M (2012) Effectiveness of intravenous lidocaine versus intravenous morphine for patients with renal colic in the emergency department. BMC Urol 12:13. https://doi.org/10.1186/1471-2490-12-13PubMedPubMedCentralCrossRef

118.

Farahmand S, Hamrah H, Arbab M, Sedaghat M, Basir Ghafouri H, Bagheri-Hariri S (2018) Pain management of acute limb trauma patients with intravenous lidocaine in emergency department. Am J Emerg Med 36(7):1231–1235. https://doi.org/10.1016/j.ajem.2017.12.027PubMedCrossRef

119.

Zink KA, Mayberry JC, Peck EG, Schreiber MA (2011) Lidocaine patches reduce pain in trauma patients with rib fractures. Am Surg 77(4):438–442PubMedCrossRef

Titel: Approaching acute pain in emergency settings; European Society for Emergency Medicine (EUSEM) guidelines—part 2: management and recommendations
verfasst von: Saïd Hachimi-Idrissi
Viliam Dobias
Wolf E. Hautz
Robert Leach
Thomas C. Sauter
Idanna Sforzi
Frank Coffey
Publikationsdatum: 15.09.2020
Verlag: Springer International Publishing
Erschienen in: Internal and Emergency Medicine / Ausgabe 7/2020
Print ISSN: 1828-0447
Elektronische ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-020-02411-2

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Approaching acute pain in emergency settings; European Society for Emergency Medicine (EUSEM) guidelines—part 2: management and recommendations

Abstract

Background

Methods

Results and conclusions

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Springer Medizin

Abstract

Background

Methods

Results and conclusions

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