Erschienen in:
01.09.2010 | Short Communication
Aprepitant against pruritus in patients with solid tumours
verfasst von:
Bruno Vincenzi, Maria Elisabetta Fratto, Daniele Santini, Giuseppe Tonini
Erschienen in:
Supportive Care in Cancer
|
Ausgabe 9/2010
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Excerpt
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant decline in quality of life, and although with use of anti-emetic drugs, it remains a significant clinical problem [
1]. Aprepitant is the first commercially available drug of a new class of neurokinin-1 receptor (NK1) antagonists. The importance of substance P and its receptor NK1 is becoming more clear in the pathophysiology of CINV. Substance P, a regulatory peptide of tachynin family, can induce vomiting binding NK1 receptors in the abdominal vagus, in the nucleus tractus solitarius and in the area postrema. Substance P has a role in many central functions, like nausea, vomiting, behaviour, anxiety, depression and pain transmission. Many central and peripheral effects of substance P are mediated by NK1 receptors [
2]. …