nach oben

The journal of nutrition, health & aging

Erschienen in:

22.10.2016

Are dietary supplements and nutraceuticals effective for musculoskeletal health and cognitive function? A scoping review

verfasst von: G. Iolascon, R. Gimigliano, M. Bianco, A. de Sire, A. Moretti, A. Giusti, N. Malavolta, S. Migliaccio, A. Migliore, N. Napoli, P. Piscitelli, G. Resmini, U. Tarantino, F. Gimigliano

Erschienen in: The journal of nutrition, health & aging | Ausgabe 5/2017

Einloggen, um Zugang zu erhalten

Abstract

Objective

The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function.

Design

Scoping review.

Methods

The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies.

Results

In literature we found 12 relevant positive studies (1 international society guidelines/recommendations, 1 systematic review, 7 randomized controlled trials, and 3 prospective cohort studies). We showed that only 16 micronutrients resulted to have appropriate scientific evidences in terms of improving musculoskeletal health and/or cognitive function in older people: beta-alanine, calcium, creatine, fluorides, leucine, magnesium, omega-3 fatty acids, potassium, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K2, and zinc.

Conclusion

This scoping review showed that selected micronutrients in adequate doses might have an ancillary role in musculoskeletal health and cognitive functions in older people.

Dagogo-Jack S. Glycemic control and chronic diabetes complications. In: Umpierrez 1. McCollum EV. A history of nutrition. The Riverside Press, Cambridge, MA, 1957;pp 234–236.

Funk C. On the chemical nature of the substance which cures polyneuritis in birds induced by a diet of polished rice. J Physiol 1911;43(5):395–400.CrossRefPubMedPubMedCentral

McCollum EV, Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem 1913;25:167–175.

McCollum EV, Simmons N, Pitz W. The relation of the unidentified dietary factors, the fat-soluble A and water-soluble B of the diet to the growth promoting properties of milk. J Biol Chem 1916;27:33–38.

FDA/CFSAN resources page, 2016. Dietary Supplement Health and Education Act of 1994. http://www.fda.gov/Food/DietarySupplements. Accessed 6 August 2015.

DeFelice S, 1989. The NutraCeutical Revolution: Fueling a Powerful, New International Market. Presented at the Harvard University Advanced Program in Biomedical Research Management and Development in Italy. http://www.fimdefelice.org/p2437.html. Accessed 6 August 2015.

Zeisel SH. Regulation of «nutraceuticals». Science 1999;17;285(5435):1853–5.CrossRef

NCBI, 2016. http://www.ncbi.nlm.nih.gov/mesh/?term=nutraceuticals. Accessed 6 August 2015.

Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A review. Res J Pharm Tech 2008;1:328–40.

10.

Fulgoni VL 3rd, Keast DR, Auestad N, Quann EE. Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003-2006. Nutr Res 2011;31(10):759–65. doi: 10.1016/j.nutres.2011.09.017.CrossRefPubMed

11.

Moyer MW. Nutrition: vitamins on trial. Nature 2014;26;510(7506):462-4. doi: 10.1038/510462a.

12.

SINut. 2012. http://www.sinut.it. Accessed 6 August 2015.

13.

Prabu SL, Suriyaprakash TN, Kumar CD, Kumar SS. Nutraceuticals and their medicinal importance. Int J Health Allied Sci 2012;1:47–53. doi: 10.4103/2278-344X.101661.CrossRef

14.

Kalra EK. Nutraceutical—definition and introduction. AAPS PharmSci 2003;5(3):E25.CrossRefPubMed

15.

Schmidt C. Controversy and Climbing Sales: Two Constants in the US Vitamins and Dietary Supplements Market. Euromonitor International 2014. http://blog. euromonitor.com/2014/01/controversy-and-climbing-sales-two-constants-in-the-usvitamins-and-dietary-supplements-market.html. Accessed 6 August 2015.

16.

WHO. Ageing. http://www.who.int/topics/ageing. Accessed 6 August 2015.

17.

ISTAT. Il futuro demografico del Paese. http://www.istat.it/it/archivio/48875. Accessed 2011;6 August 2015.

18.

Eastell R, Yergey AL, Vieira NE, Cedel SL, Kumar R, Riggs BL. Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action. J Bone Miner Res 1991;6(2):125–32.CrossRefPubMed

19.

Dai Z, Wang R, Ang LW, Yuan JM, Koh WP. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study. Osteoporos Int 2013;24(7):2049–59. doi: 10.1007/s00198-012-2233-1.CrossRefPubMed

20.

Syed FA, Ng AC. The pathophysiology of the aging skeleton. Curr Osteoporos Rep. 2010;8(4):235–40. doi: 10.1007/s11914-010-0035-y.CrossRefPubMed

21.

Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci 2003;15;23(8):3295-301.

22.

Jack CR Jr, Shiung MM, Weigand SD, O’Brien PC, Gunter JL, Boeve BF, Knopman DS, Smith GE, Ivnik RJ, Tangalos EG, Petersen RC. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neurology 2005;65(8):1227–31.CrossRefPubMedPubMedCentral

23.

Ries ML, Carlsson CM, Rowley HA, Sager MA, Gleason CE, Asthana S, Johnson SC. Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review. J Am Geriatr Soc 2008;56(5):920–34. doi: 10.1111/j.1532-5415.2008.01684.x.CrossRefPubMedPubMedCentral

24.

Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One 2010;5(9):e12244. doi: 10.1371/journal.pone.0012244.CrossRefPubMedPubMedCentral

25.

Egger M, Dickersin K, Smith GD. Problems and limitations in conducting systematic reviews. In: Egger M, Smith GD, Altman DG (eds) Systematic Reviews in Health Care: Meta-Analysis in Context, 2nd edn. BMJ Books, London, UK 2001.CrossRef

26.

European Commission 2016. EU Register of nutrition and health claims made on foods. http://ec.europa.eu/nuhclaims. Accessed 6 August 2015.

27.

European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals. http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolendatoler.pdf. Accessed 2006;6 August 2015.

28.

del Favero S, Roschel H, Solis MY, Hayashi AP, Artioli GG, Otaduy MC, Benatti FB, Harris RC, Wise JA, Leite CC, Pereira RM, de Sá-Pinto AL, Lancha-Junior AH, Gualano B. Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino Acids 2012;43(1):49–56. doi: 10.1007/s00726-011-1190-x.CrossRefPubMed

29.

Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY; ESCEO Task Force. The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas 2014;79(1):122–32. doi: 10.1016/j.maturitas.2014.07.005.CrossRefPubMed

30.

Aguiar AF, Januário RS, Junior RP, Gerage AM, Pina FL, do Nascimento MA, Padovani CR, Cyrino ES. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol 2013;113(4):987–96. doi: 10.1007/s00421-012-2514-6.CrossRefPubMed

31.

Grey A, Garg S, Dray M, Purvis L, Horne A, Callon K, Gamble G, Bolland M, Reid IR, Cundy T. Low-dose fluoride in postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab 2013;98(6):2301–7. doi: 10.1210/jc.2012-4062.CrossRefPubMed

32.

Pennings B, Groen B, de Lange A, Gijsen AP, Zorenc AH, Senden JM, van Loon LJ. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 2012;302(8):E992–9. doi: 10.1152/ajpendo.00517.2011.CrossRefPubMed

33.

Wall BT, Hamer HM, des Lange A, Kiskini A, Groen BB, Senden JM, Gijsen AP, Verdijk LB, van Loon LJ. Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin Nutr 2013;32(3):412–9. doi: 10.1016/j. clnu.2012.09.002.CrossRefPubMed

34.

Yang Y, Breen L, Burd NA, Hector AJ, Churchward-Venne TA, Josse AR, Tarnopolsky MA, Phillips SM. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr 2012;108(10):1780–8. doi: 10.1017/S0007114511007422.CrossRefPubMed

35.

Orchard TS, Larson JC, Alghothani N, Bout-Tabaku S, Cauley JA, Chen Z, LaCroix AZ, Wactawski-Wende J, Jackson RD. Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr 2014;99(4):926–33. doi: 10.3945/ajcn.113.067488.CrossRefPubMedPubMedCentral

36.

Ruxton CH, Derbyshire E, Toribio-Mateas M. Role of fatty acids and micronutrients in healthy ageing: a systematic review of randomised controlled trials set in the context of European dietary surveys of older adults. J Hum Nutr Diet. 2015; doi: 10.1111/jhn.12335.

37.

Zhu K, Devine A, Prince RL. The effects of high potassium consumption on bone mineral density in a prospective cohort study of elderly postmenopausal women. Osteoporos Int 2009;20(2):335–40. doi: 10.1007/s00198-008-0666-3CrossRefPubMed

38.

Ruiz-Ramos M, Vargas LA, Fortoul Van der Goes TI, Cervantes-Sandoval A, Mendoza-Nunez VM. Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J Nutr Health Aging 2010;14(6):467–72.CrossRefPubMed

39.

Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 2013;24(9):2499–507. doi: 10.1007/s00198-013-2325-6.CrossRefPubMed

40.

Nielsen FH, Lukaski HC, Johnson LK, Roughead ZK. Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women. Br J Nutr 2011;06(12):1872–9. doi: 10.1017/S0007114511002352.CrossRef

41.

Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30(3):279–89.CrossRefPubMed

42.

Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32(2):225–33.CrossRefPubMed

43.

Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids 2008;34(4):547–54. doi: 10.1007/s00726-007-0008-3.CrossRefPubMed

44.

Kendrick IP, Kim HJ, Harris RC, Kim CK, Dang VH, Lam TQ, Bui TT, Wise JA. The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres. Eur J Appl Physiol 2009;106(1):131–8. doi: 10.1007/s00421-009-0998-5.CrossRefPubMed

45.

Wilczynski C, Camacho P. Calcium use in the management of osteoporosis: continuing questions and controversies. Curr Osteoporos Rep 2014;12(4):396–402. doi: 10.1007/s11914-014-0234-z.CrossRefPubMed

46.

Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc 2001;33(12):2111–7.CrossRefPubMed

47.

Farley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells. Science 1983;222(4621):330–2.CrossRefPubMed

48.

Riggs BL, Hodgson SF, O’Fallon WM, Chao EY, Wahner HW, Muhs JM, Cedel SL, Melton LJ 3rd. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 322(12):802-9.

49.

Kleerekoper M, Peterson EL, Nelson DA, Phillips E, Schork MA, Tilley BC, Parfitt AM. A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis. Osteoporos Int 1991;1(3):155–61.CrossRefPubMed

50.

Lundy MW, Stauffer M, Wergedal JE, Baylink DJ, Featherstone JD, Hodgson SF, Riggs BL. Histomorphometric analysis of iliac crest bone biopsies in placebo-treated versus fluoride-treated subjects. Osteoporos Int 1995;5(2):115–29.CrossRefPubMed

51.

Vestergaard P, Jorgensen NR, Schwarz P, Mosekilde L. Effects of treatment with fluoride on bone mineral density and fracture risk—a meta-analysis. Osteoporos Int 2008;19(3):257–68.CrossRefPubMed

52.

Komar B, Schwingshackl L, Hoffmann G. Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging 19(4):437-46. doi: 10.1007/s12603-014-0559-4.

53.

Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999;69(4):727–36.PubMed

54.

New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 2000;71(1):142–51.PubMed

55.

Dyall SC, Michael-Titus AT. Neurological benefits of omega-3 fatty acids. Neuromolecular Med 2008;10(4):219–35. doi: 10.1007/s12017-008-8036-z.CrossRefPubMed

56.

Ryan AS, Astwood JD, Gautier S, Kuratko CN, Nelson EB, Salem N Jr. Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 2010;82(4–6):305–14. doi: 10.1016/j.plefa.2010.02.007.CrossRefPubMed

57.

Nilsson A, Radeborg K, Salo I, Björck I. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr J 2012;11:99. doi: 10.1186/1475-2891-11-99.CrossRefPubMedPubMedCentral

58.

Bushinsky DA, Riordon DR, Chan JS, Krieger NS. Decreased potassium stimulates bone resorption. Am J Physiol 1997;272(6 Pt 2):F774–80.PubMed

59.

Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Mitra S, Arcaroli J, Kuhn K, Abraham E. Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Am J Physiol Cell Physiol 2004;286(3):C683–92.CrossRefPubMed

60.

Stahl W, Sies H. Antioxidant defense: vitamins E and C and carotenoids. Diabetes 1997;46 Suppl 2:S14–8.CrossRefPubMed

61.

Boland RL. Vitamin D and Muscle. In: Feldman D, Glorieux G, Pike W (eds) Vitamin D, 2nd edn. Academic Press, CA, USA, 2005;pp 885–898.

62.

Boland RL. VDR activation of intracellular signaling pathways in skeletal muscle. Mol Cell Endocrinol 2011;347(1–2):11–6. doi: 10.1016/j.mce.2011.05.021.CrossRefPubMed

63.

Dirks-Naylor AJ, Lennon-Edwards S. The effects of vitamin D on skeletal muscle function and cellular signaling. J Steroid Biochem Mol Biol 2011;125(3–5):159–68. doi: 10.1016/j.jsbmb.2011.03.003.CrossRefPubMed

64.

Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int 2002;13(3):187–94.CrossRefPubMed

65.

Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Curr Osteoporos Rep 2014;12(1):74–81. doi: 10.1007/s11914-014-0193-4.CrossRefPubMed

66.

Zamboni M, Zoico E, Tosoni P, Zivelonghi A, Bortolani A, Maggi S, Di Francesco V, Bosello O. Relation between vitamin D, physical performance, and disability in elderly persons. J Gerontol A Biol Sci Med Sci 2002;57(1):M7–11.CrossRefPubMed

67.

Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, Dawson-Hughes B. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 2004;80(3):752–8.PubMed

68.

Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 2005;16(11):1425–31.CrossRefPubMed

69.

Houston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, Johnson MA, Schwartz GG, Kritchevsky SB. Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2007;62(4):440–6.CrossRefPubMedPubMedCentral

70.

Toffanello ED, Perissinotto E, Sergi G, Zambon S, Musacchio E, Maggi S, Coin A, Sartori L, Corti MC, Baggio G, Crepaldi G, Manzato E. Vitamin D and physical performance in elderly subjects: the Pro.V.A study. PLoS One 2012;7(4):e34950. doi: 10.1371/journal.pone.0034950.CrossRefPubMedPubMedCentral

71.

Iolascon G, de Sire A, Calafiore D, Moretti A, Gimigliano R, Gimigliano F. Hypovitaminosis D is associated with a reduction in upper and lower limb muscle strength and physical performance in post-menopausal women: a retrospective study. Aging Clin Exp Res 2015;27 Suppl 1:S23-30. doi: 10.1007/s40520-015-0405-5.

72.

Civelek GM, Pekyavas NO, Cetin N, Cosar SN, Karatas M. Association of vitamin D deficiency with muscle strength and quality of life in postmenopausal women. Climacteric 2014;17(4):472–7. doi: 10.3109/13697137.2014.898265.CrossRefPubMed

73.

McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr 2009;90(4):889–907. doi: 10.3945/ajcn.2009.27930.CrossRefPubMed

74.

Teucher B, Dainty JR, Spinks CA, Majsak-Newman G, Berry DJ, Hoogewerff JA, Foxall RJ, Jakobsen J, Cashman KD, Flynn A, Fairweather-Tait SJ. Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. J Bone Miner Res 2008;23:1477–1485.CrossRefPubMed

75.

Wu AM, Huang CQ, Lin ZK, Tian NF, Ni WF, Wang XY, Xu HZ, Chi YL. The relationship between vitamin A and risk of fracture: meta-analysis of prospective studies. J Bone Miner Res 2014;29(9):2032–9. doi: 10.1002/jbmr.2237.CrossRefPubMed

76.

Wall BT, Cermak NM, van Loon LJ. Dietary protein considerations to support active aging. Sports Med 2014;44 Suppl 2:S185–94. doi: 10.1007/s40279-014-0258-7.CrossRefPubMed

77.

Crichton GE, Elias MF, Davey A, Alkerwi A, Dore GA. Higher Cognitive Performance Is Prospectively Associated with Healthy Dietary Choices: The Maine Syracuse Longitudinal Study. J Prev Alzheimers Dis 2015;2(1):24–32.PubMedPubMedCentral

78.

Ragle RL, Sawitzke AD. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs Aging 2012;29(9):717–31.CrossRefPubMed

Titel: Are dietary supplements and nutraceuticals effective for musculoskeletal health and cognitive function? A scoping review
verfasst von: G. Iolascon
R. Gimigliano
M. Bianco
A. de Sire
A. Moretti
A. Giusti
N. Malavolta
S. Migliaccio
A. Migliore
N. Napoli
P. Piscitelli
G. Resmini
U. Tarantino
F. Gimigliano
Publikationsdatum: 22.10.2016
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 5/2017
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-016-0823-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Are dietary supplements and nutraceuticals effective for musculoskeletal health and cognitive function? A scoping review

Abstract

Objective

Design

Methods

Results

Conclusion

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Design

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2017

Relationship between breakfast skipping and obesity among elderly: Cross-sectional analysis of the HEIJO-KYO study

Overweight and abdominal obesity association with all- cause and cardiovascular mortality in the elderly aged 80 and over: A cohort study

Adherence to the Mediterranean diet and all-cause mortality risk in an elderly Italian population: Data from the ILSA study

Effects of running wheel activity and dietary HMB and B–alanine co-supplementation on muscle quality in aged male rats

Construct validation of the Dietary Inflammatory Index among African Americans

Bone degeneration and its recovery in SMP30/GNL-knockout mice

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin