Background
Method
Study design and participants
Measures
Fibromyalgia
Other musculoskeletal pain
Widespread or localized pain
Subjective hearing loss
Audiometry
Depression and anxiety symptoms
Demographic and socioeconomic status
Statistical analysis
Results
Descriptive account of participants
Fibromyalgia (FM) | Musculoskeletal pain without fibromyalgia (MS) | Reference | Comparison (P-value)a | |||
---|---|---|---|---|---|---|
FM vs Ref | MS vs Ref | |||||
Total | N (%) | 1 483 (100) | 18 808 (100) | 24 203 (100) | ||
Women | N (%) | 1 275 (85.97) | 9 948 (52.89) | 11 860 (49.00) | 0.000 | 0.000 |
Age | Mean (SD) | 52.43 (12.02) | 51.64 (15.56) | 45.99 (16.77) | 0.000 | 0.000 |
Single | N (%) | 453 (30.55) | 6 340 (33.71) | 10 319 (42.63) | 0.000 | 0.000 |
Education | 0.000 | 0.000 | ||||
Primary school | N (%) | 716 (48.28) | 7 042 (37.44) | 6 647 (27.46) | ||
High school | N (%) | 552 (37.22) | 7 936 (42.19) | 11 091 (45.82) | ||
Higher | N (%) | 215 (14.50) | 3 830 (20.36) | 6 465 (26.71) | ||
Audiometry (MTH) | Mean (SD) | 16.82 (13.19) | 17.65 (14.80) | 14.29 (13.86) | 0.000 | 0.000 |
HADS-Ab | Mean (SD) | 6.38 (4.16) | 4.63 (3.43) | 3.57 (2.86) | 0.000 | 0.000 |
HADS-Db | Mean (SD) | 5.07 (3.65) | 3.83 (3.15) | 2.81 (2.67) | 0.000 | 0.000 |
Local musculoskeletal pain (LMS) | Widespread musculoskeletal pain (WMS) | Comparison LMS vs WMS (P-value)a | ||
---|---|---|---|---|
Total | N (%) | 8 749 (100) | 10 059 (100) | |
Women | N (%) | 4 158 (47.52) | 5 790 (57.56) | 0.000 |
Age | Mean (SD) | 50.65 (16.21) | 52.50 (14.91) | 0.000 |
Single | N (%) | 3 067 (35.06) | 3 273 (32.54) | 0.000 |
Education | 0.000 | |||
Primary school | N (%) | 2 937 (33.57) | 4 105 (40.81) | |
High school | N (%) | 3 805 (43.49) | 4 131 (41.07) | |
Higher | N (%) | 2 007 (22.94) | 1 823 (18.12) | |
Audiometry (MTH) | Mean (SD) | 17.26 (14.81) | 18.00 (14.78) | 0.001 |
HADS-Ab | Mean (SD) | 4.13 (3.11) | 5.07 (3.63) | 0.000 |
HADS-Db | Mean (SD) | 3.48 (2.97) | 4.14 (3.27) | 0.000 |
The relationship between fibromyalgia and subjective hearing loss
Subjective hearing loss | Unadjusted | Adjusted for age, education and hearing loss (model 1) | In addition adjusted for anxiety and depression (model 2) | ||
---|---|---|---|---|---|
Yes | No | ||||
N (%) | N (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
WOMEN (13 135) | 1 085 (8.26) | 12 050 (91.74) | |||
Fibromyalgia | |||||
No | 805 (6.79) | 11 055 (93.21) | 1.000 ref | 1.000 ref | 1.000 ref |
Yes | 280 (21.96) | 995 (78.04) | 3.865 (3.324–4.493) | 5.182 (4.278–6.277) | 4.578 (3.622–5.787) |
Age | |||||
20–35 | 89 (2.09) | 4 162 (97.91) | 1.000 ref | 1.000 ref | 1.000 ref |
36–49 | 135 (3.36) | 3 881 (96.64) | 1.627 (1.240–2.133) | 1.069 (0.801–1.426) | 0.974 (0.713–1.329) |
50–64 | 279 (10.24) | 2 445 (89.76) | 5.336 (4.182–6.809) | 2.072 (1.565–2.743) | 1.952 (1.437–2.651) |
65+ | 582 (27.15) | 1 562 (72.85) | 17.424 (13.837–21.942) | 2.354 (1.747–3.172) | 2.071 (1.474–2.909) |
Education | |||||
Primary school | 659 (15.45) | 3 606 (84.55) | 1.000 ref | 1.000 ref | 1.000 ref |
High school | 247 (4.49) | 5 255 (95.51) | 0.257 (0.221–0.299) | 0.807 (0.665–0.980) | 0.736 (0.588–0.921) |
Higher | 179 (5.15) | 3 189 (94.69) | 0.307 (0.259–0.365) | 0.811 (0.658–1.000) | 0.799 (0.618–1.032) |
WHO hearing impairment | |||||
None (<26 dB) | 377 (3.31) | 11 007 (96.69) | 1.000 ref | 1.000 ref | 1.000 ref |
Mild (26–40 dB) | 325 (28.33) | 822 (71.67) | 11.544 (9.793–13.606) | 7.859 (6.404–9.644) | 8.082 (6.340–10.302) |
Moderate (41–60 dB) | 291 (59.75) | 196 (40.25) | 43.348 (35.201–53.380) | 31.533 (24.444–40.678) | 35.904 (26.424–48.786) |
Severe (>60 dB) | 92 (78.63) | 25 (21.37) | 107.442 (68.247–169.148) | 81.067 (50.190–130.939) | 90.053 (49.378–164.234) |
HADS–A ≥8b | |||||
No | 606 (6.11) | 9 312 (93.89) | 1.000 ref | 1.000 ref | |
Yes | 178 (11.83) | 1 327 (88.17) | 2.061 (1.727–2.460) | 1.732 (1.353–2.217) | |
HADS-D ≥8b | |||||
No | 786 (6.91) | 10 590 (93.09) | 1.000 ref | 1.000 ref | |
Yes | 155 (17.44) | 734 (82.56) | 2.845 (2.358–3.433) | 1.131 (0.849–1.508) | |
Nagelkerke R2 | 0.389 | 0.375 | |||
−2 Log likelihood | 5 056.265 | 3 744.466 | |||
MEN (12 551) | 1 404 (11.19) | 11 147 (88.81) | |||
Fibromyalgia | |||||
No | 1 335 (10.82) | 11 008 (89.18) | 1.000 ref | 1.000 ref | 1.000 ref |
Yes | 69 (33.17) | 139 (66.83) | 4.093 (3.050–5.493) | 4.368 (3.082–6.189) | 4.523 (3.077–6.647) |
Age | |||||
20–35 | 150 (3.93) | 3 666 (96.07) | 1.000 ref | 1.000 ref | 1.000 ref |
36–49 | 173 (4.54) | 3 638 (95.46) | 1.162 (0.930–1.453) | 1.007 (0.800–1.268) | 0.966 (0.757–1.233) |
50–64 | 332 (12.40) | 2 346 (87.60) | 3.459 (2.833–4.223) | 1.692 (1.351–2.119) | 1.609 (1.262–2.050) |
65+ | 749 (33.35) | 1 497 (66.65) | 12.228 (10.159–14.718) | 2.116 (1.661–2.695) | 1.837 (1.404–2.403) |
Education | |||||
Primary school | 611 (19.72) | 2 487 (80.28) | 1.000 ref | 1.000 ref | 1.000 ref |
High school | 505 (8.22) | 5 636 (91.78) | 0.365 (0.321–0.414) | 0.914 (0.783–1.066) | 0.886 (0.757–1.233) |
Higher | 288 (8.70) | 3 024 (91.30) | 0.388 (0.334–0.450) | 0.824 (0.691–0.981) | 0.765 (0.622–0.940) |
WHO hearing impairment | |||||
None (<26 dB) | 438 (4.36) | 9 618 (95.64) | 1.000 ref | 1.000 ref | 1.000 ref |
Mild (26–40 dB) | 439 (28.16) | 1 120 (71.84) | 8.607 (7.437–9.961) | 5.625 (4.713–6.715) | 6.157 (5.054–7.500) |
Moderate (41–60 dB) | 410 (53.39) | 358 (46.61) | 25.148 (21.194–29.841) | 15.120 (12.203–18.734) | 17.012 (13.214–21.902) |
Severe (>60 dB) | 117 (69.64) | 51 (30.36) | 50.376 (35.766–70.955) | 31.310 (21.721–45.133) | 29.566 (19.085–45.802) |
HADS-A ≥8b | |||||
No | 949 (9.20) | 9 368 (90.80) | 1.000 ref | 1.000 ref | |
Yes | 128 (13.43) | 825 (86.57) | 1.532 (1.257–1.867) | 1.583 (1.225–2.044) | |
HADS-D ≥8b | |||||
No | 1 040 (9.49) | 9 915 (90.51) | 1.000 ref | 1.000 ref | |
Yes | 183 (21.79) | 657 (78.21) | 2.655 (2.227–3.166) | 1.429 (1.118–1.826) | |
Nagelkerke R2 | 0.319 | 0.296 | |||
−2 Log likelihood | 6 593.252 | 5 200.042 |
The relationship between other musculoskeletal pain than fibromyalgia and subjective hearing loss
Subjective hearing loss | Unadjusted | Adjusted for age, education and hearing loss (model 1) | In addition adjusted for anxiety and depression (model 2) | ||
---|---|---|---|---|---|
Yes | No | ||||
N (%) | N (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
WOMEN (21 808) | 2 383 (10.93) | 19 425 (89.07) | |||
Musculoskeletal pain | |||||
None | 805 (6.79) | 11 055 (93.21) | 1.000 ref | 1.000 ref | 1.000 ref |
Local | 558 (13.42) | 3 600 (86.58) | 2.129 (1.899–2.386) | 1.901 (1.657–2.182) | 1.915 (1.627–2.255) |
Widespread | 1 020 (17.62) | 4 770 (82.38) | 2.937 (2.661–3.240) | 3.145 (2.788–3.548) | 3.073 (2.668–3.539) |
Age | |||||
20–35 | 156 (2.61) | 5 829 (97.39) | 1.000 ref | 1.000 ref | 1.000 ref |
36–49 | 283 (4.22) | 6 426 (95.78) | 1.646 (1.349–2.007) | 1.212 (0.987–1.490) | 1.172 (0.940–1.460) |
50–64 | 552 (11.21) | 4 371 (88.79) | 4.719 (3.934–5.661) | 2.202 (1.800–2.693) | 2.220 (1.785–2.762) |
65+ | 1 392 (33.21) | 2 799 (66.79) | 18.583 (15.654–22.059) | 2.916 (2.357–3.608) | 3.064 (2.415–3.887) |
Education | |||||
Primary school | 1 470 (19.31) | 6 143 (80.69) | 1.000 ref | 1.000 ref | 1.000 ref |
High school | 505 (5.68) | 8 387 (94.32) | 0.252 (0.226–0.280) | 0.761 (0..665–0.870) | 0.771 (0.661–0.899) |
Higher | 408 (7.69) | 4 895 (92.31) | 0.348 (0.310–0.391) | 0.836 (0.726–0.964) | 0.896 (0.756–1.061) |
WHO hearing impairment | |||||
None (<26 dB) | 835 (4.52) | 17 619 (95.48) | 1.000 ref | 1.000 ref | 1.000 ref |
Mild (26–40 dB) | 723 (33.32) | 1 447 (66.68) | 10.543 (9.419–11.805) | 6.150 (5.367–7.047) | 6.393 (5.445–7.506) |
Moderate (41–60 dB) | 644 (67.08) | 316 (32.92) | 43.002 (36.959–50.035) | 25.229 (21.099–30.168) | 25.202 (20.300–31.286) |
Severe (>60 dB) | 181 (80.80) | 43 (19.20) | 88.819 (63.239–124.745) | 57.021 (39.859–81.574) | 53.218 (34.360–82.427) |
HADS-A ≥8b | |||||
No | 1 365 (8.61) | 14 493 (91.39) | 1.000 ref | 1.000 ref | |
Yes | 405 (14.06) | 2 476 (85.94) | 1.737 (1.542–1.956) | 1.703 (1.448–2.004) | |
HADS-D ≥8b | |||||
No | 1 707 (9.21) | 16 830 (90.79) | 1.000 ref | 1.000 ref | |
Yes | 361 (20.74) | 1 379 (79.25) | 2.581 (2.275–2.928) | 1.285 (1.063–1.552) | |
Nagelkerke R2 | 0.390 | 0.378 | |||
−2 Log likelihood | 10 334.633 | 7 789.274 | |||
MEN (21 203) | 3 576 (16.87) | 17 627 (83.13) | |||
Musculoskeletal pain | |||||
None | 1 335 (10.82) | 11 008 (89.18) | 1.000 ref | 1.000 ref | 1.000 ref |
Local | 884 (19.26) | 3 707 (80.74) | 1.966 (1.792–2.158) | 1.851 (1.662–2.061) | 1.796 (1.590–2.029) |
Widespread | 1 357 (31.79) | 2 912 (68.21) | 3.843 (3.526–4.187) | 3.739 (3.375–4.142) | 3.618 (3.225–4.058) |
Age | |||||
20–35 | 263 (5.07) | 4 926 (94.93) | 1.000 ref | 1.000 ref | 1.000 ref |
36–49 | 489 (7.60) | 5 946 (92.40) | 1.540 (1.320–1.798) | 1.124 (0.957–1.321) | 1.064 (0.898–1.261) |
50–64 | 1 076 (19.97) | 4 311 (80.03) | 4.675 (4.061–5.382) | 1.978 (1.692–2.321) | 1.934 (1.638–2.284) |
65+ | 1 758 (41.70) | 2 444 (58.30) | 13.396 (11.665–15.385) | 2.375 (2.001–2.818) | 2.152 (1.784–2.597) |
Education | |||||
Primary school | 1 658 (27.29) | 4 418 (72.71) | 1.000 ref | 1.000 ref | 1.000 ref |
High school | 1 313 (12.96) | 8 822 (87.04) | 0.397 (0.366–0.430) | 0.892 (0.808–0.985) | 0.884 (0.791–0.988) |
Higher | 605 (12.12) | 4 387 (87.88) | 0.367 (0.332–0.407) | 0.757 (0.671–0.854) | 0.688 (0.598–0.791) |
WHO hearing impairment | |||||
None (<26 dB) | 1 222 (7.50) | 15 080 (92.50) | 1.000 ref | 1.000 ref | 1.000 ref |
Mild (26–40 dB) | 1 135 (37.36) | 1 903 (62.64) | 7.360 (6.701–8.084) | 4.775 (4.270–5.341) | 4.842 (4.361–5.600) |
Moderate (41–60 dB) | 962 (62.63) | 574 (37.37) | 20.682 (18.368–23.288) | 12.982 (11.221–15.020) | 13.428 (11.428–16.060) |
Severe (>60 dB) | 257 (78.59) | 70 (21.41) | 45.307 (34.566–59.386) | 31.241 (23.419–41.677) | 29.054 (20.611–40.956) |
HADS-A ≥8b | |||||
No | 2 386 (14.25) | 14 352 (85.75) | 1.000 ref | 1.000 ref | |
Yes | 448 (21.13) | 1 672 (78.87) | 1.612 (1.440–1.804) | 1.443 (1.242–1.676) | |
HADS-D ≥8b | |||||
No | 2 577 (14.39) | 1 533 (85.61) | 1.000 ref | 1.000 ref | |
Yes | 585 (30.02) | 1 364 (69.98) | 2.552 (2.296–2.836) | 1.555 (1.342–1.801) | |
Nagelkerke R2 | 0.361 | 0.348 | |||
−2 Log likelihood | 14 108.014 | 11 358.869 |