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Clinical Reviews in Allergy & Immunology

Erschienen in:

02.09.2020

Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

verfasst von: Joana Costa, Simona Lucia Bavaro, Sara Benedé, Araceli Diaz-Perales, Cristina Bueno-Diaz, Eva Gelencser, Julia Klueber, Colette Larré, Daniel Lozano-Ojalvo, Roberta Lupi, Isabel Mafra, Gabriel Mazzucchelli, Elena Molina, Linda Monaci, Laura Martín-Pedraza, Cristian Piras, Pedro M. Rodrigues, Paola Roncada, Denise Schrama, Tanja Cirkovic-Velickovic, Kitty Verhoeckx, Caterina Villa, Annette Kuehn, Karin Hoffmann-Sommergruber, Thomas Holzhauser

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1/2022

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Abstract

This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.

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Titel: Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?
verfasst von: Joana Costa
Simona Lucia Bavaro
Sara Benedé
Araceli Diaz-Perales
Cristina Bueno-Diaz
Eva Gelencser
Julia Klueber
Colette Larré
Daniel Lozano-Ojalvo
Roberta Lupi
Isabel Mafra
Gabriel Mazzucchelli
Elena Molina
Linda Monaci
Laura Martín-Pedraza
Cristian Piras
Pedro M. Rodrigues
Paola Roncada
Denise Schrama
Tanja Cirkovic-Velickovic
Kitty Verhoeckx
Caterina Villa
Annette Kuehn
Karin Hoffmann-Sommergruber
Thomas Holzhauser
Publikationsdatum: 02.09.2020
Verlag: Springer US
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1/2022
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-020-08810-9

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Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

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