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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

Are selected IL-1 polymorphisms and selected subgingival microorganisms significantly associated to periodontitis in type 2 diabetes patients? a clinical study

Zeitschrift:
BMC Oral Health > Ausgabe 1/2015
Autoren:
Herbert Deppe, Thomas Mücke, Stefan Wagenpfeil, Marco Kesting, Julia Karl, Sebastian Noe, Anton Sculean
Wichtige Hinweise

Competing of interests

The authors declare that they have no competing interests.

Authors’contributions

HD: conception and design; acquisition of data; drafting and revising the manuscript. TM: conception and design; acquisition of data; drafting and revising the manuscript. SW: analysis and interpretation of data; drafting and revising the manuscript. MK: analysis and interpretation of data; drafting and revising the manuscript. JK: analysis and interpretation of data; drafting and revising the manuscript. SN: analysis and interpretation of data; drafting and revising the manuscript. AS: conception and design; acquisition of data; drafting and revising the manuscript. All authors read and approved the final manuscript, agree to be accountable for all aspects of the work, and will ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Abstract

Background

We evaluated the periodontal conditions in patients with type 2 diabetes mellitus compared to metabolically healthy controls, and determined whether periodontal interleukin genotypes and microorganisms differed between participants with and without type 2 diabetes mellitus.

Methods

From April 2011 to July 2012, we prospectively enrolled healthy controls and patients with type 2 diabetes mellitus. Evaluation included assessment of medical and periodontal findings. We also recorded the presence of several interleukin gene variants and specific microorganisms, both available through commercially available diagnostic kits. Statistical significance was tested by the chi-square test and student’s t-test.

Results

We enrolled 52 patients with type 2 diabetes mellitus and 52 healthy controls. Compared with controls, periodontal disease was significantly more severe in patients with type 2 diabetes mellitus for the following: plaque index, bleeding on probing, pocket probing depth, clinical attachment loss, severe periodontal destruction (i.e., clinical attachment loss ≥ 5 mm), and number of teeth. However, statistical analysis failed to detect significant differences with respect to the periodontal-related interleukin genotypes (p ≥ 0.58) or the selected oral microbiota (p ≥ 0.15).

Conclusion

Based on these results, it may be assumed that chronic periodontitis in patients with type 2 diabetes mellitus is most strongly associated with inadequate oral hygiene. Periodontal interleukin genotypes and differences in oral microbiota seem to play a subordinate role.
Literatur
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