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Erschienen in: Breast Cancer 2/2014

01.03.2014 | Original Article

Are there high-risk subgroups for isolated locoregional failure in patients who had T1/2 breast cancer with one to three positive lymph nodes and received mastectomy without radiotherapy?

verfasst von: Yasushi Hamamoto, Shozo Ohsumi, Kenjiro Aogi, Syuichi Shinohara, Naomi Nakajima, Masaaki Kataoka, Shigemitsu Takashima

Erschienen in: Breast Cancer | Ausgabe 2/2014

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Abstract

Background

To define the factors associated with increased risk of isolated locoregional failure that may justify postmastectomy radiotherapy in patients with T1/2 breast cancer and 1–3 positive lymph nodes.

Methods

Between 1990 and 2002, 248 patients who had pT1–2 breast cancer and 1–3 positive lymph nodes were treated with mastectomy without radiotherapy (age 32–84, median 54).

Results

Median follow-up time was 82 months (range 2–189 months). For all patients, the 8-year isolated locoregional failure-free rate was 95 %. In univariate analysis, hormone receptor status and administration of hormone therapy were statistically significant factors, and vascular invasion was the borderline significant factor for isolated locoregional failure-free rates (P = 0.0377, 0.0181, and 0.0555, respectively). The 8-year isolated locoregional failure-free rates were 98 % for patients with positive hormone receptor status and 90 % for patients with negative hormone receptor status, 97 % for patients who received hormone therapy and 89 % for patients who did not receive hormone therapy, 92 % for patients with vascular invasion and 97 % for patients without vascular invasion. In multivariate analysis for hormone receptor status and vascular invasion, the former was statistically significant (P = 0.0491) and the latter was borderline significant (P = 0.0664). When patients had both negative hormone receptor and positive vascular invasion status, the 8-year isolated locoregional failure-free rates decreased to 83 %.

Conclusions

With regard to patients who had pT1/2 breast cancer and 1–3 positive lymph nodes, isolated locoregional failure was not common in general; however, patients who had both negative hormone receptor status and vascular invasion were comparatively high-risk patients for isolated locoregional failure.
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Metadaten
Titel
Are there high-risk subgroups for isolated locoregional failure in patients who had T1/2 breast cancer with one to three positive lymph nodes and received mastectomy without radiotherapy?
verfasst von
Yasushi Hamamoto
Shozo Ohsumi
Kenjiro Aogi
Syuichi Shinohara
Naomi Nakajima
Masaaki Kataoka
Shigemitsu Takashima
Publikationsdatum
01.03.2014
Verlag
Springer Japan
Erschienen in
Breast Cancer / Ausgabe 2/2014
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-012-0369-7