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Erschienen in: Breast Cancer Research 6/2007

01.12.2007 | Letter

Are triple-negative tumours and basal-like breast cancer synonymous?

verfasst von: Emad A Rakha, David SP Tan, William D Foulkes, Ian O Ellis, Andrew Tutt, Torsten O Nielsen, Jorge S Reis-Filho

Erschienen in: Breast Cancer Research | Ausgabe 6/2007

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Excerpt

Kreike and colleagues [1] examined the gene expression and pathological characteristics of a retrospectively accrued cohort of 97 triple-negative phenotype (TNP) (oestrogen receptor [ER]-negative, progesterone receptor-negative, and HER2-negative) invasive breast cancers. TNP tumours were profiled with oligonucleotide microarrays and compared with a control group of 102 non-TNP tumours, which were obtained from an unrelated project. The authors then investigated whether the TNP would accurately identify basal-like cancers, by assessing the correlation coefficient between the gene expression profiles of each TNP cancer and the centroids of the molecular subgroups as defined by Hu and colleagues [2]. As expected, the majority (91%) of TNP tumours were classified as 'basal-like' tumours. However, 9% of tumours either showed a normal-like phenotype or were unclassifiable [1]. The authors presented a hierarchical clustering analysis of both TNP and control cases, based on a partial 'intrinsic gene list' and a different reference RNA when compared with those reported by Hu and colleagues [2], and observed that all of the TNP group and 18.6% of the control non-TNP group clustered together [1]. Based on the above results, the authors drew the provocative conclusions that 'basal-like tumours can be reliably defined by triple-negative immunohistochemistry' and that 'triple-negative tumours are synonymous with basal-like tumours'. …
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Metadaten
Titel
Are triple-negative tumours and basal-like breast cancer synonymous?
verfasst von
Emad A Rakha
David SP Tan
William D Foulkes
Ian O Ellis
Andrew Tutt
Torsten O Nielsen
Jorge S Reis-Filho
Publikationsdatum
01.12.2007
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 6/2007
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1827

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