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Breast Cancer Research

Erschienen in:

01.04.2011 | Review

Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management

verfasst von: Stéphanie Gaillard, Vered Stearns

Erschienen in: Breast Cancer Research | Ausgabe 2/2011

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Abstract

Aromatase inhibitors are widely used as adjuvant therapy in postmenopausal women with hormone receptor-positive breast cancer. While the agents are associated with slightly improved survival outcomes when compared to tamoxifen alone, bone and musculoskeletal side effects are substantial and often lead to discontinuation of therapy. Ideally, the symptoms should be prevented or adequately treated. This review will focus on bone and musculoskeletal side effects of aromatase inhibitors, including osteoporosis, fractures, and arthralgias. Recent advances have been made in identifying potential mechanisms underlying these effects. Adequate management of symptoms may enhance patient adherence to therapy, thereby improving breast cancer-related outcomes.

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Titel: Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management
verfasst von: Stéphanie Gaillard
Vered Stearns
Publikationsdatum: 01.04.2011
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 2/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2818

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management

Abstract

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Springer Medizin

Abstract

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