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08.11.2024 | Note

Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity

verfasst von: Hitoshi Kamauchi, Mayu Tanaka, Kakeru Koyama, Yuka Kiba, Masashi Kitamura, Yoshiaki Sugita

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

Two novel aromatic polyketides, penicanesins J and K (1, 2), were isolated from the marine-derived fungus Didymella aeria, along with the known compound integrastatin B (3). The structures of the new compounds were determined by NMR spectroscopy and synthetic methods. The isolated compounds were tested for monoamine oxidase (MAO) B inhibition, anti-amyloid beta (Aβ) aggregation, and protective activity against H₂O₂-induced cell death in human neuroblastoma SH-SY5Y cells. Integrastatin B (3) showed potential activity for inhibition of Aβ aggregation and protection against H₂O₂-induced cell death.

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Titel: Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity
verfasst von: Hitoshi Kamauchi
Mayu Tanaka
Kakeru Koyama
Yuka Kiba
Masashi Kitamura
Yoshiaki Sugita
Publikationsdatum: 08.11.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01858-3

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Springer Medizin

Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity

Abstract

Graphical Abstract

Weitere Artikel der Ausgabe 1/2025

3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells

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3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells

Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity

Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation

Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability

Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway

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