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01.12.2016 | Research article | Ausgabe 1/2016 Open Access

BMC Surgery 1/2016

Arterial blood gases predict long-term prognosis in stage I non-small cell lung cancer patients

Zeitschrift:
BMC Surgery > Ausgabe 1/2016
Autoren:
Shinjiro Mizuguchi, Takashi Iwata, Nobuhiro Izumi, Takuma Tsukioka, Shoji Hanada, Hiroaki Komatsu, Noritoshi Nishiyama
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

All authors were involved in the preparation of this manuscript. SM performed statistical analysis, wrote and revised the manuscript. NN and SM designed the study. SM, TI, NI, TT, SH, HK and NN performed the operation and participated in collecting the data. All authors read and approved the final manuscript.

Abstract

Background

Preoperative hypercapnia and hypoxemia are reportedly risk factors for postoperative complications. This study aimed to establish the long-term survival risk associated with abnormal preoperative arterial blood gases (ABGs) in patients with non-small cell lung cancer (NSCLC).

Methods

This study involved 414 patients with stage I NSCLC who underwent lobectomy/bilobectomy with mediastinal lymph node dissection. The patients were divided into groups with normal (n = 269) and abnormal (n = 145) ABGs.

Results

The patients in the normal ABG group (median age 67 years) were significantly younger than those in the abnormal ABG group (median age 70 years). There were no significant differences between the groups in gender, performance status, pathological stage, histology, postoperative complications, or preoperative comorbidity, except for chronic obstructive pulmonary disease/pulmonary fibrosis. The 3-, 5- and 10-year survival rates in the normal and abnormal ABG groups were 87, 77 and 56, and 78 , 63 and 42 %, respectively (p = 0.006). According to multivariate analysis, age, gender, performance status, non-adenocarcinoma, differentiation of resected tumor, pathological stage, any prior tumor and abnormal ABGs (risk ratio, 1.61) were independent prognostic factors.

Conclusions

Abnormal ABGs predict long-term survival risk in patients with NSCLC, which is important for planning therapeutic strategies.
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