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26.06.2018 | Sleep Breathing Physiology and Disorders • Original Article

Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study

verfasst von: Emilia Sforza, Sandrine Millasseau, David Hupin, Jean-Claude Barthélémy, Frédéric Roche

Erschienen in: Sleep and Breathing | Ausgabe 1/2019

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Abstract

Introduction

Several studies suggest in middle-aged subjects a relationship between arterial stiffness, a cardiovascular risk marker, and moderate to severe obstructive sleep apnea (OSA). No extensive data are present in older subjects. This study explores this association in a sample of healthy older subjects suffering OSA.

Methods

A total of 101 volunteers aged 75.3 ± 0.7 years were examined at the hospital sleep center. Each subject was assessed for medical history, body mass index and 24-h blood pressure measures, biological blood samples, and home polygraphy in 2002–2003 (P2) as well as in 2009–2010 (P4). Arterial stiffness was also assessed using carotid-femoral and carotid-radial pulse wave velocity (cfPWV and crPWV) during P4 examination.

Results

The total group consisted of 59 women and 42 men with a mean apnea-hypopnea index (AHI) of 17.8 ± 12.1 and a mean oxygen desaturation index (ODI) of 9.8 ± 8.9. No-OSA (AHI < 15) represented 50% of the sample, and severe cases (AHI > 30) 17%. No significant differences had been founded between men and women for blood pressure, cfPWV, and crPWV. Considering the severity of the AHI, no significant differences between groups were present for PWV and blood pressure values. No difference for PWV was present for subjects with and without hypertension. No correlation was found between PWV value and AHI and ODI values at P2 or between P2 and P4 visits. cfPWV was higher in patients demonstrating incident hypertension during the follow-up.

Conclusions

In this sample of older subjects, PWV is not affected by AHI and ODI but was associated with incident hypertension. These results may suggest potential protective and adaptive mechanisms in older sleep apnea patients.

Clinical trial registrations

NCT 00759304 and NCT 00766584.

Young T, Palta M, DempseyJ SJ, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235CrossRef

Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM (2013) Increased prevalence of sleep-disordered breathings in adults. Am J Epidemiol 177:1006–1014CrossRefPubMedPubMedCentral

Senaratna CV, Perret JL, Lodge CJ, Lowe JA, Campbell BE, Matheson MC, Hamilton GS, Dharmage SC (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81CrossRefPubMed

Hongyo K, Ito N, Yamamoto K, Yamamoto K, Takeda M, Oguro R, Takami Y, Takeya Y, Sugimoto K, Rakugi H (2017) Factors associated with the severity of obstructive sleep apnea in older adults. Geriatr Gerontol Int 17:614–621CrossRefPubMed

Tkacova R, McNicholas WT, Javorsky M, Fietze I, Sliwinski P, Parati G, Grote L, Hedner J. European Sleep Apnoea Database study collaborators (2014) Nocturnal intermittent hypoxia predicts prevalent hypertension in the European sleep Apnoea database cohort study. Eur Respir J 44:931–941CrossRef

Greco C, Spallone V (2015) Obstructive sleep apnoea syndrome and diabetes. Fortuitous association or interaction? Curr Diabetes Rev 12:129–155CrossRefPubMed

Destors M, Tamisier R, Baguet JP, Ley P, Pepin JL (2014) Cardiovascular morbidity associated with obstructive sleep apnea syndrome. Rev Mal Resp 31:375–385CrossRef

Mc Nicholas WT, Bonsignore M et al (2007) Management committee of EU COST ACTION B26. Sleep apnea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 29:156–178CrossRef

Chung S, Yoon IY, Lee CH, Kim JW (2010) The association of nocturnal hypoxemia with arterial stiffness and endothelial dysfunction in male patients with obstructive sleep apnea. Respiration 79:363–369CrossRefPubMed

10.

Kraiczi H, Caidahl K, Samuelsson A, Peker J, Hedner J (2001) Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep. Chest 119:1085–1091CrossRefPubMed

11.

Levy P, Pepin JL, Arnaud C, Buguet JP, Dematteis M, Mach F (2009) Obstructive sleep apnea and atherosclerosis. Prog Cardiovasc Dis 51:400–410CrossRefPubMed

12.

Butt M, Khair OA, Dwivedi G, Shantsila A, Shantsila E, Lip GY (2011) Myocardial perfusion by myocardial contrast echocardiography and endothelial dysfunction in obstructive sleep apnea. Hypertension 58:417–424CrossRefPubMed

13.

Wada T, Kodaira K, Fuijshiro K, Maie K, Tsukiyama E, Fukumoto T, Uchida T, Yamasaki S (1994) Correlation of ultrasound-measured common carotid artery stiffness with pathological findings. Arterioscler Thromb 14:479–482CrossRefPubMed

14.

Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker Bourdier H (2006) European network for non-invasive investigation of large arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 21:2588–2605CrossRef

15.

Vachopoulos C, Aznaouridis K, Stephanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 121:505–511

16.

Doonan RJ, Scheffer P, Lalli M, Kimoff RJ, Petridou ET, Daskalopoulos ME, Daskalopoulou SS, Daskalopoulos ME, Daskapoulou SS (2011) Increased arterial stiffness in obstructive sleep apnea: a systematic review. Hypertension Res 34:23–32CrossRef

17.

Jelic S, Bartels MN, Mateika JH, Ngai P, DrMeersman RE, Basner RC (2002) Arterial stiffness increases during obstructive sleep apneas. Sleep 25:850–855PubMed

18.

Sarinc Ulasli S, Sariaydin M, Ozkececi G, Gunay E, Halici B, Unlu M (2016) Arterial stiffness in obstructive sleep apnoea: is there difference between daytime and nighttime? Respirology 21:1480–1485CrossRefPubMed

19.

Chung S, Yoon I, Lee CH, Kim JW (2010) The association of nocturnal hypoxemia with arterial stiffness and endothelial dysfunction in male patients with obstructive sleep apnea syndrome. Respiration 79:363–369CrossRefPubMed

20.

Phillips CL, Butlin M, Wong KK, Avolio AP (2013) Is obstructive sleep apnoea causally related to arterial stiffness? A critical review of the experimental evidence. Sleep Med Rev 17:7–18CrossRefPubMed

21.

Charalambos V, Konstatinos A, Christodoulos S (2010) Prediction of cardiovascular event and all-cause mortality with arterial stiffness. J Am Coll Cardiol 55:1318–1327CrossRef

22.

Laurent S, Boutourie P, Asmar R (2002) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hpertensive patients. Hypertension 39:10–15CrossRefPubMed

23.

Vlachopoulos C, Xaplanteris P, Aboyans V, Brodman M, Cifkova R, Cosentino F, De Carlo M, Gallino A, Landmesser U, Laurent S, Lekakis J, Mikhailidis DP, Naka KK, Protogerou AD, Rizzoni D, Schmidt-Trucksass A, Van Bortel L, Weber T, Yamashina A, Zimlichmann R, Boutourie P, Cockcroft J, O’Rourke M, Park JB, Schillacci G, Sillesen H, Townsend RR (2015) The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation : Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 241:507–532CrossRefPubMed

24.

Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RH (2002) Aortic pulse wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106:2085–2090CrossRef

25.

Meaume S, Benetos A, Henri OF, Rudnichi A, Safar ME (2001) Aortic pulse wave velocity predicts cardiovascular mortality in subjets >70 years of age. Artherioscler Thromb Vasc Biol 21:2046–2050CrossRef

26.

Barthélémy JC, Pichot V, Dauphinot V, Celle S, Laurent B, Garcin A, Maudoux D, Kerleroux J, Lacour JR, Kossovsky M, Gasoz JM, Roche F (2007) Autonomic nervous system activity and decline as prognostic indicators of cardiovascular and cerebrovascular events. The PROOF study. Neuroepidemiology 29:18–28CrossRefPubMed

27.

Sforza E, Sabri M, DaCosta A, Isaaz K, Barthélémy JC, Roche F (2015) Echocardiographic findings in healthy elderly people with sleep-disordered breathing. J Clin Sleep Med 11:975–980PubMedPubMedCentral

28.

Mancia G, De Backer G, Dominiczak A et al (2007) 2007 Guidelines for the management of arterial hypertension: The Task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 25:1105–1187CrossRefPubMed

29.

O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plant GE (2002) Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertension 15:426–444CrossRef

30.

(1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The report of the American Academy of Sleep Medicine Task Force. Sleep 22:667–89

31.

Pavlova MK, Duffy JF, Shea SA (2008) Polysomnographic respiratory abnormalities in asymptomatic individuals. Sleep 31:241–248CrossRefPubMedPubMedCentral

32.

Pepin JL, Tamisier R, Baguet JP, Lévy P (2013) Arterial health is related to obstructive sleep apnea severity and improves with CPAP treatment. Sleep Med Rev 17:3–5CrossRefPubMed

33.

Seetho JW, Asher R, Parke RJ, Craig S, Duffy N, Hardy KJ, Wilding JP (2015) Effect of CPAP on arterial stiffness in severely obese patients with obstructive sleep apnea. Sleep Breath 19:1155–1165CrossRefPubMed

34.

Toprak A, Reddy J, Chen W, Srinivasan S, Berenson G (2009) Relation of pulse pressure and arterial stiffness to concentric left ventricular hypertrophy in young me (from the Bogalusa heart study). Am J Cardiol 103:978–984CrossRefPubMed

35.

Watanabe H, Ohtsuka S, Kakihana M, Sugishita Y (1993) Coronary circulation in dogs with an experimental decrease in aortic compliance. J Am Coll Cardiol 21:1497–1506CrossRefPubMed

36.

Litvin AY, Sukmarova ZN, Elfimova EM, Aksenova AV, Galitsin PV, Rogoza AN, Chazova IE (2013) Effect of CPAP on vascular risk factors in patients with obstructive sleep apnea and arterial hypertension. Vasc Health Risk Manag 9:229–235CrossRefPubMedPubMedCentral

37.

Vlachopoulos C, Aznaouidid K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness. J of Am Coll Cardiology 55:1318–1327CrossRef

38.

Wang J, Yu W, Gao M, Zhang F, Gu C, Yu Y, Wei Y (2015) Impact of obstructive sleep apnea syndrome on endothelial function, arterial stiffening and serum inflammatory markers: an updated meta-analysis and metaregression of 18 studies. J Am Heart Assoc 4(11). https://doi.org/10.1161/JAHA.115.002454

39.

Tamisier R, Borel J, Millasseau S (2016) Arterial stiffness in patients with obstructive sleep apnea syndrome: an individual meta-analysis of contributing factors. J Hypertens Suppl 2:e100. https://doi.org/10.1097/01.hip.000001593.31023.87 CrossRef

40.

Bruno RM, Rossi L, Fabrini M, Durani E, Di Coscio E, Maestri M, Guidi P, Frenzilli G, Salvetti A, Taddei S, Bonanni E, Ghiadoni L (2013) Renal vasodilating capacity and endothelial function are impaired in patients with obstructive sleep apnea and no traditional cardiovascular risk factors. J Hypertens 31:1456–1464CrossRefPubMed

41.

Sforza E, Roche F (2016) Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach. Hypoxia 4:99–108CrossRefPubMedPubMedCentral

42.

Lavie P, Lavie L (2009) Unexpected survival advantages in elderly people with moderate sleep apnoea. J Sleep Res 18:397–403CrossRefPubMed

Titel: Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study
verfasst von: Emilia Sforza
Sandrine Millasseau
David Hupin
Jean-Claude Barthélémy
Frédéric Roche
Publikationsdatum: 26.06.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 1/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1683-x

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Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study

Abstract

Introduction

Methods

Results

Conclusions

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Abstract

Introduction

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Conclusions

Clinical trial registrations

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