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Erschienen in: Arthritis Research & Therapy 3/2007

01.06.2007 | Review

Arthritis and pain. Future targets to control osteoarthritis pain

verfasst von: Andy Dray, Simon J Read

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2007

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Abstract

Clinical presentation of osteoarthritis (OA) is dominated by pain during joint use and at rest. OA pain is caused by aberrant functioning of a pathologically altered nervous system with key mechanistic drivers from peripheral nerves and central pain pathways. This review focuses on symptomatic pain therapy exemplified by molecular targets that alter sensitization and hyperexcitability of the nervous system, for example, opioids and cannabinoids. We highlight opportunities for targeting inflammatory mediators and their key receptors (for example, prostanoids, kinins, cytokines and chemokines), ion channels (for example, NaV1.8, NaV1.7 and CaV2.2) and neurotrophins (for example, nerve growth factor), noting evidence that relates to their participation in OA etiology and treatment. Future neurological treatments of pain appear optimistic but will require the systematic evaluation of emerging opportunities.
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Literatur
1.
Zurück zum Zitat Bellamy N, Sothern RB, Campbell J: Rhythmic variations in pain perception in osteoarthritis of the knee. J Rheumatol. 1990, 17: 364-372.PubMed Bellamy N, Sothern RB, Campbell J: Rhythmic variations in pain perception in osteoarthritis of the knee. J Rheumatol. 1990, 17: 364-372.PubMed
2.
Zurück zum Zitat Bellamy N, Sothern RB, Campbell J, Buchanan WW: Rhythmic variations in pain, stiffness and manual dexterity in hand osteoarthritis. Ann Rheum Dis. 2002, 61: 1075-1080. 10.1136/ard.61.12.1075.PubMedCentralPubMed Bellamy N, Sothern RB, Campbell J, Buchanan WW: Rhythmic variations in pain, stiffness and manual dexterity in hand osteoarthritis. Ann Rheum Dis. 2002, 61: 1075-1080. 10.1136/ard.61.12.1075.PubMedCentralPubMed
3.
Zurück zum Zitat Creamer P, Hunt M, Dieppe P: Pain mechanisms in osteoarthritis of the knee: Effect of intra-articular anaesthetic. J Rheumatol. 1996, 23: 1031-1036.PubMed Creamer P, Hunt M, Dieppe P: Pain mechanisms in osteoarthritis of the knee: Effect of intra-articular anaesthetic. J Rheumatol. 1996, 23: 1031-1036.PubMed
4.
Zurück zum Zitat Crawford RW, Gie GA, Ling RS, Murray DW: Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip. J Bone Joint Surg Br. 1998, 80: 279-281. 10.1302/0301-620X.80B2.8299.PubMed Crawford RW, Gie GA, Ling RS, Murray DW: Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip. J Bone Joint Surg Br. 1998, 80: 279-281. 10.1302/0301-620X.80B2.8299.PubMed
5.
Zurück zum Zitat Kosek E, Ordeberg G: Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain. 2000, 88: 69-78. 10.1016/S0304-3959(00)00310-9.PubMed Kosek E, Ordeberg G: Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain. 2000, 88: 69-78. 10.1016/S0304-3959(00)00310-9.PubMed
6.
Zurück zum Zitat Buffington ALH, Hanlon CA, McKeown MJ: Acute and persistent pain modulation of attention-related anterior cingulated fMRI activations. Pain. 2005, 113: 172-184. 10.1016/j.pain.2004.10.006.PubMed Buffington ALH, Hanlon CA, McKeown MJ: Acute and persistent pain modulation of attention-related anterior cingulated fMRI activations. Pain. 2005, 113: 172-184. 10.1016/j.pain.2004.10.006.PubMed
7.
Zurück zum Zitat Rowbotham MC, Kidd BL, Porreca F: Role of central sensitization in chronic pain: Osteoarthritis and rheumatoid arthritis compared to neuropathic pain. Proceedings of the 11th World Congress on Pain. August 21 – 26th 2005, Sydney, Australia. Edited by: Flor H, Kalso E, Dostrovsky J. 2006, Seattle; IASP Press Rowbotham MC, Kidd BL, Porreca F: Role of central sensitization in chronic pain: Osteoarthritis and rheumatoid arthritis compared to neuropathic pain. Proceedings of the 11th World Congress on Pain. August 21 – 26th 2005, Sydney, Australia. Edited by: Flor H, Kalso E, Dostrovsky J. 2006, Seattle; IASP Press
8.
Zurück zum Zitat Fraenkel M, Bogardus ST, Concato J, Wittink DR: Treatment options in knee OA. Arch Intern Med. 2004, 164: 1299-1304. 10.1001/archinte.164.12.1299.PubMed Fraenkel M, Bogardus ST, Concato J, Wittink DR: Treatment options in knee OA. Arch Intern Med. 2004, 164: 1299-1304. 10.1001/archinte.164.12.1299.PubMed
9.
Zurück zum Zitat Yaksh TL: Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand. 1997, 41: 94-111.PubMed Yaksh TL: Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand. 1997, 41: 94-111.PubMed
10.
Zurück zum Zitat Hurley RW, Hammond DL: The analgesic effects of supraspinal μ and δ opioid receptor agonists are potentiated during persistent inflammation. J Neurosci. 2000, 20: 1249-1259.PubMed Hurley RW, Hammond DL: The analgesic effects of supraspinal μ and δ opioid receptor agonists are potentiated during persistent inflammation. J Neurosci. 2000, 20: 1249-1259.PubMed
11.
Zurück zum Zitat Sawynok J: Topical and peripherally acting analgesics. Pharmacol Rev. 2003, 55: 1-20. 10.1124/pr.55.1.1.PubMed Sawynok J: Topical and peripherally acting analgesics. Pharmacol Rev. 2003, 55: 1-20. 10.1124/pr.55.1.1.PubMed
12.
Zurück zum Zitat Likar R, Schafer M, Paulak F, Sittl R, Pipam W, Schalk H, Geissler D, Bernatzky G: Intraarticular morphine analgesia in chronic pain patients with osteoarthritis. Anesth Analg. 1997, 84: 1313-1317. 10.1097/00000539-199706000-00025.PubMed Likar R, Schafer M, Paulak F, Sittl R, Pipam W, Schalk H, Geissler D, Bernatzky G: Intraarticular morphine analgesia in chronic pain patients with osteoarthritis. Anesth Analg. 1997, 84: 1313-1317. 10.1097/00000539-199706000-00025.PubMed
13.
Zurück zum Zitat Menendez L, Lastra A, Meana A, Hidalgo A, Baamonde A: Analgesic effects of loperamide in bone cancer pain in mice. Pharmacol Biochem Behav. 2005, 81: 114-121. 10.1016/j.pbb.2005.02.007.PubMed Menendez L, Lastra A, Meana A, Hidalgo A, Baamonde A: Analgesic effects of loperamide in bone cancer pain in mice. Pharmacol Biochem Behav. 2005, 81: 114-121. 10.1016/j.pbb.2005.02.007.PubMed
14.
Zurück zum Zitat Whiteside GT, Boulet JM, Walker K: The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid). J Pharmacol Exp Ther. 2005, 314: 1234-1240. 10.1124/jpet.105.088351.PubMed Whiteside GT, Boulet JM, Walker K: The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid). J Pharmacol Exp Ther. 2005, 314: 1234-1240. 10.1124/jpet.105.088351.PubMed
15.
Zurück zum Zitat Dray A: Alternatives to mu-opioid analgesics: delta-opioid and galanin-receptor selective compounds. Progress in Pain Research and Management. Edited by: Kalso E, McQuay HJ, Wiesenfeld-Hallin Z. 1999, Seattle: IASP Press, 269-280. Dray A: Alternatives to mu-opioid analgesics: delta-opioid and galanin-receptor selective compounds. Progress in Pain Research and Management. Edited by: Kalso E, McQuay HJ, Wiesenfeld-Hallin Z. 1999, Seattle: IASP Press, 269-280.
16.
Zurück zum Zitat Cahill CM, Morinville A, Lee M-C, Vincent J-P, Collier B, Beaudet A: Prolonged morphine treatment targets δ opioid receptors to neuronal plasma membranes and enhances δ-mediated antinociception. J Neurosci. 2001, 21: 7598-7607.PubMed Cahill CM, Morinville A, Lee M-C, Vincent J-P, Collier B, Beaudet A: Prolonged morphine treatment targets δ opioid receptors to neuronal plasma membranes and enhances δ-mediated antinociception. J Neurosci. 2001, 21: 7598-7607.PubMed
17.
Zurück zum Zitat Koblish M, LaBuda CJ, Ajello CW, Gu M, Zhou QJ, Tuthill PA, Chu G, Le Bourdonnec B, Dolle RE, Little PJ: Anti-hyperalgesic activity of a novel delta-opioid receptor agonist. Soc Neurosci Abst. 2005, 490.14- Koblish M, LaBuda CJ, Ajello CW, Gu M, Zhou QJ, Tuthill PA, Chu G, Le Bourdonnec B, Dolle RE, Little PJ: Anti-hyperalgesic activity of a novel delta-opioid receptor agonist. Soc Neurosci Abst. 2005, 490.14-
18.
Zurück zum Zitat Dray A: Kinins and their receptors in hyperalgesia. Can J Physiol Pharmacol. 1997, 75: 704-712. 10.1139/cjpp-75-6-704.PubMed Dray A: Kinins and their receptors in hyperalgesia. Can J Physiol Pharmacol. 1997, 75: 704-712. 10.1139/cjpp-75-6-704.PubMed
19.
Zurück zum Zitat Dray A, Perkins MN: Bradykinin and inflammatory pain. Trends Neurosci. 1993, 16: 99-104. 10.1016/0166-2236(93)90133-7.PubMed Dray A, Perkins MN: Bradykinin and inflammatory pain. Trends Neurosci. 1993, 16: 99-104. 10.1016/0166-2236(93)90133-7.PubMed
20.
Zurück zum Zitat Wotherspoon G, Winter J: Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system. Neurosci Lett. 2000, 294: 175-178. 10.1016/S0304-3940(00)01561-5.PubMed Wotherspoon G, Winter J: Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system. Neurosci Lett. 2000, 294: 175-178. 10.1016/S0304-3940(00)01561-5.PubMed
21.
Zurück zum Zitat Shughrue PJ, Ky B, Austin CP: Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. J Comp Neurol. 2003, 465: 372-384. 10.1002/cne.10846.PubMed Shughrue PJ, Ky B, Austin CP: Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. J Comp Neurol. 2003, 465: 372-384. 10.1002/cne.10846.PubMed
22.
Zurück zum Zitat Levy D, Zochodne DW: Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000, 86: 265-271. 10.1016/S0304-3959(00)00256-6.PubMed Levy D, Zochodne DW: Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000, 86: 265-271. 10.1016/S0304-3959(00)00256-6.PubMed
23.
Zurück zum Zitat Fox A, Wotherspoon G, McNair K, Hudson L, Patel S, Gentry C, Winter L: Regulation and function of spinal and peripheral neuronal B(1) bradykinin receptors in inflammatory mechanical hyperalgesia. Pain. 2003, 104: 683-691. 10.1016/S0304-3959(03)00141-6.PubMed Fox A, Wotherspoon G, McNair K, Hudson L, Patel S, Gentry C, Winter L: Regulation and function of spinal and peripheral neuronal B(1) bradykinin receptors in inflammatory mechanical hyperalgesia. Pain. 2003, 104: 683-691. 10.1016/S0304-3959(03)00141-6.PubMed
24.
Zurück zum Zitat Ferreira J, Beirith A, Mori MAS, Araujo RC, Bader M, Pesqero JB, Calixto JB: Reduced nerve injury induced neuropathic pain in kinin B1 receptor knock-out mice. J Neurosci. 2005, 25: 2405-2412. 10.1523/JNEUROSCI.2466-04.2005.PubMed Ferreira J, Beirith A, Mori MAS, Araujo RC, Bader M, Pesqero JB, Calixto JB: Reduced nerve injury induced neuropathic pain in kinin B1 receptor knock-out mice. J Neurosci. 2005, 25: 2405-2412. 10.1523/JNEUROSCI.2466-04.2005.PubMed
25.
Zurück zum Zitat Eisenbarth H, Rukwied R, Petersen M, Schmelz M: Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin. Pain. 2004, 110: 197-204. 10.1016/j.pain.2004.03.031.PubMed Eisenbarth H, Rukwied R, Petersen M, Schmelz M: Sensitization to bradykinin B1 and B2 receptor activation in UV-B irradiated human skin. Pain. 2004, 110: 197-204. 10.1016/j.pain.2004.03.031.PubMed
26.
Zurück zum Zitat Vellani V, Zachrisson O, McNaughton PA: Functional bradykinin B1 receptors are expressed in nociceptive neurons and are upregulated by the neurotrophin GDNF. J Physiol. 2004, 560: 391-401. 10.1113/jphysiol.2004.067462.PubMedCentralPubMed Vellani V, Zachrisson O, McNaughton PA: Functional bradykinin B1 receptors are expressed in nociceptive neurons and are upregulated by the neurotrophin GDNF. J Physiol. 2004, 560: 391-401. 10.1113/jphysiol.2004.067462.PubMedCentralPubMed
27.
Zurück zum Zitat Marceau F, Hess JF, Bachvarov DR: The B1 receptors for kinins. Pharmacol Rev. 1998, 50: 357-386.PubMed Marceau F, Hess JF, Bachvarov DR: The B1 receptors for kinins. Pharmacol Rev. 1998, 50: 357-386.PubMed
28.
Zurück zum Zitat Liang YF, Haake B, Reeh PW: Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol. 2001, 532: 229-239. 10.1111/j.1469-7793.2001.0229g.x.PubMedCentralPubMed Liang YF, Haake B, Reeh PW: Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol. 2001, 532: 229-239. 10.1111/j.1469-7793.2001.0229g.x.PubMedCentralPubMed
29.
Zurück zum Zitat Fox A, Kaur S, Li B, Panasar M, Saha U, Davis C, Dragoni I, Colley S, Ritchie T, Bevan S, et al: Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol. 2005, 144: 889-899. 10.1038/sj.bjp.0706139.PubMedCentralPubMed Fox A, Kaur S, Li B, Panasar M, Saha U, Davis C, Dragoni I, Colley S, Ritchie T, Bevan S, et al: Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol. 2005, 144: 889-899. 10.1038/sj.bjp.0706139.PubMedCentralPubMed
30.
Zurück zum Zitat Stewart JM: Bradykinin antagonists: discovery and development. Peptides. 2004, 25: 527-732. 10.1016/j.peptides.2003.10.016.PubMed Stewart JM: Bradykinin antagonists: discovery and development. Peptides. 2004, 25: 527-732. 10.1016/j.peptides.2003.10.016.PubMed
31.
Zurück zum Zitat Burgess GM, Perkins MN, Rang HP, Campbell EA, Browen MC, McIntyre P, Urban L, Dziadulewicz EK, Ritchie TJ, Hallet A, et al: Bradyzide, a potent nonpeptide B2 bradykinin receptors antagonist with long lasting oral activity in animal models of inflammatory hyperalgesia. Br J Pharmacol. 2000, 129: 77-86. 10.1038/sj.bjp.0703012.PubMedCentralPubMed Burgess GM, Perkins MN, Rang HP, Campbell EA, Browen MC, McIntyre P, Urban L, Dziadulewicz EK, Ritchie TJ, Hallet A, et al: Bradyzide, a potent nonpeptide B2 bradykinin receptors antagonist with long lasting oral activity in animal models of inflammatory hyperalgesia. Br J Pharmacol. 2000, 129: 77-86. 10.1038/sj.bjp.0703012.PubMedCentralPubMed
32.
Zurück zum Zitat Gougat J, Ferrari B, Lionel S, Planchenault C, Poncelet M, Maruani J, Alonso R, Cudennec A, Croci T, Guagnini F, et al: SSR240612 [(2R)-2-[((3R0-3-(1,3-benzodiol-5-yl)-3-{[(6-methoxy-2-napthyl)sulfonyl]amino}propanoyl)amino]-3-(4-{[2R,6S)-2,6-dimethylpiperidyl]methyl}phenyl}-N-isoproyl-Nmethylpropana mide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2004, 309: 661-669. 10.1124/jpet.103.059527.PubMed Gougat J, Ferrari B, Lionel S, Planchenault C, Poncelet M, Maruani J, Alonso R, Cudennec A, Croci T, Guagnini F, et al: SSR240612 [(2R)-2-[((3R0-3-(1,3-benzodiol-5-yl)-3-{[(6-methoxy-2-napthyl)sulfonyl]amino}propanoyl)amino]-3-(4-{[2R,6S)-2,6-dimethylpiperidyl]methyl}phenyl}-N-isoproyl-Nmethylpropana mide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2004, 309: 661-669. 10.1124/jpet.103.059527.PubMed
33.
Zurück zum Zitat Gabra BH, Sirois P: Beneficial effects of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-953, in attenuating streptozotocin-diabetic thermal hyperalgesia. Peptides. 2003, 24: 1131-1139. 10.1016/j.peptides.2003.06.003.PubMed Gabra BH, Sirois P: Beneficial effects of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-953, in attenuating streptozotocin-diabetic thermal hyperalgesia. Peptides. 2003, 24: 1131-1139. 10.1016/j.peptides.2003.06.003.PubMed
34.
Zurück zum Zitat Flechtenmacher J, Talke M, Veith D, Heil K, Gebauer A, Schoenharting M: Icatibant induces pain relief in patients with osteoarthritis of the knee. Proceedings of the 9th World Congress of the OsteoArthritis Research Society Internation (OARSI). Chicago. 12: P332-December 2–5 2004 Flechtenmacher J, Talke M, Veith D, Heil K, Gebauer A, Schoenharting M: Icatibant induces pain relief in patients with osteoarthritis of the knee. Proceedings of the 9th World Congress of the OsteoArthritis Research Society Internation (OARSI). Chicago. 12: P332-December 2–5 2004
35.
Zurück zum Zitat Fox A, Bevan S: Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs. 2005, 14: 695-703. 10.1517/13543784.14.6.695.PubMed Fox A, Bevan S: Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs. 2005, 14: 695-703. 10.1517/13543784.14.6.695.PubMed
36.
Zurück zum Zitat Rice ASC, Farquhar-Smith WP, Nagy I: Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukot Essent Fatty Acids. 2002, 66: 243-256. 10.1054/plef.2001.0362.PubMed Rice ASC, Farquhar-Smith WP, Nagy I: Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukot Essent Fatty Acids. 2002, 66: 243-256. 10.1054/plef.2001.0362.PubMed
37.
Zurück zum Zitat Mbvundula EC, Bunning RA, Rainsford KD: Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in vitro. J Pharm Pharmacol. 2006, 58: 351-358. 10.1211/jpp.58.3.0009.PubMed Mbvundula EC, Bunning RA, Rainsford KD: Arthritis and cannabinoids: HU-210 and Win-55,212-2 prevent IL-1alpha-induced matrix degradation in bovine articular chondrocytes in vitro. J Pharm Pharmacol. 2006, 58: 351-358. 10.1211/jpp.58.3.0009.PubMed
38.
Zurück zum Zitat Kreitzer Ac, Regeher WG: Retrograde signaling by endocannabinoids. Curr Opin Neurobiol. 2002, 12: 324-330. 10.1016/S0959-4388(02)00328-8.PubMed Kreitzer Ac, Regeher WG: Retrograde signaling by endocannabinoids. Curr Opin Neurobiol. 2002, 12: 324-330. 10.1016/S0959-4388(02)00328-8.PubMed
39.
Zurück zum Zitat de Novellis V, Mariani L, Palazzo E, Vita D, Marabese I, Scafuro M, Rossi F, Maione S: Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat. Neuroscience. 2005, 134: 269-281. 10.1016/j.neuroscience.2005.03.014.PubMed de Novellis V, Mariani L, Palazzo E, Vita D, Marabese I, Scafuro M, Rossi F, Maione S: Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat. Neuroscience. 2005, 134: 269-281. 10.1016/j.neuroscience.2005.03.014.PubMed
40.
Zurück zum Zitat Walker JM, Huang SM, Strangman NM, Tsou K, Sanudo-Pena MC: Pain modulation by release of the endogenous cannabinoid anandamide. Proc Natl Acad Sci USA. 1999, 96: 12198-12203. 10.1073/pnas.96.21.12198.PubMedCentralPubMed Walker JM, Huang SM, Strangman NM, Tsou K, Sanudo-Pena MC: Pain modulation by release of the endogenous cannabinoid anandamide. Proc Natl Acad Sci USA. 1999, 96: 12198-12203. 10.1073/pnas.96.21.12198.PubMedCentralPubMed
41.
Zurück zum Zitat Campbell FA, Tramer MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ: Are cannabinoids an effective and safe treatment option in the management of pain? A quantitative systematic review. BMJ. 2001, 323: 13-16. 10.1136/bmj.323.7303.13.PubMedCentralPubMed Campbell FA, Tramer MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ: Are cannabinoids an effective and safe treatment option in the management of pain? A quantitative systematic review. BMJ. 2001, 323: 13-16. 10.1136/bmj.323.7303.13.PubMedCentralPubMed
42.
Zurück zum Zitat Dyson A, Peacock M, Chen A, Courade J-P, Yaqoob , Groark A, Brain C, Loong Y, Fox A: Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat. Pain. 2005, 116: 129-137. 10.1016/j.pain.2005.03.037.PubMed Dyson A, Peacock M, Chen A, Courade J-P, Yaqoob , Groark A, Brain C, Loong Y, Fox A: Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat. Pain. 2005, 116: 129-137. 10.1016/j.pain.2005.03.037.PubMed
43.
Zurück zum Zitat Richardson JD, Kilo S, Hargreaves KM: Cannabinoids reduce hyperalgesia and inflammation via interactions with peripheral CB1 receptors. Pain. 1998, 75: 111-119. 10.1016/S0304-3959(97)00213-3.PubMed Richardson JD, Kilo S, Hargreaves KM: Cannabinoids reduce hyperalgesia and inflammation via interactions with peripheral CB1 receptors. Pain. 1998, 75: 111-119. 10.1016/S0304-3959(97)00213-3.PubMed
44.
Zurück zum Zitat Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. JAMA. 2003, 290: 1757-1762. 10.1001/jama.290.13.1757.PubMed Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. JAMA. 2003, 290: 1757-1762. 10.1001/jama.290.13.1757.PubMed
45.
Zurück zum Zitat Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F: CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?. Curr Opin Pharmacol. 2003, 3: 62-67. 10.1016/S1471-4892(02)00004-8.PubMed Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F: CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?. Curr Opin Pharmacol. 2003, 3: 62-67. 10.1016/S1471-4892(02)00004-8.PubMed
46.
Zurück zum Zitat Labuda CJ, Koblish M, Little PJ: Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol. 2005, 527: 172-175. 10.1016/j.ejphar.2005.10.020.PubMed Labuda CJ, Koblish M, Little PJ: Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol. 2005, 527: 172-175. 10.1016/j.ejphar.2005.10.020.PubMed
47.
Zurück zum Zitat Valenzano KJ, Tafesse L, Lee G, Harrison JE, Bulet JM, Gottshall SL, Mark L, Pearson MS, Miller W, Shan S, et al: Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology. 2005, 48: 658-672. 10.1016/j.neuropharm.2004.12.008.PubMed Valenzano KJ, Tafesse L, Lee G, Harrison JE, Bulet JM, Gottshall SL, Mark L, Pearson MS, Miller W, Shan S, et al: Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology. 2005, 48: 658-672. 10.1016/j.neuropharm.2004.12.008.PubMed
48.
Zurück zum Zitat Elmes SJR, Winyard LA, Medhurst A, Clayton SJ, Wilson NM, Kendall AW, Chapman V: Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain. 2005, 118: 327-335. 10.1016/j.pain.2005.09.005.PubMed Elmes SJR, Winyard LA, Medhurst A, Clayton SJ, Wilson NM, Kendall AW, Chapman V: Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain. 2005, 118: 327-335. 10.1016/j.pain.2005.09.005.PubMed
49.
Zurück zum Zitat Sokal DM, Elmes SJR, Kendall DA, Chapman V: Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of Cb2 receptors in anaesthetized rats. Neuropharmacology. 2003, 45: 404-411. 10.1016/S0028-3908(03)00195-3.PubMed Sokal DM, Elmes SJR, Kendall DA, Chapman V: Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of Cb2 receptors in anaesthetized rats. Neuropharmacology. 2003, 45: 404-411. 10.1016/S0028-3908(03)00195-3.PubMed
50.
Zurück zum Zitat Cravatt BF, Lichtman AH: The endogenous cannabinoid system and its role in nociceptive behavior. J Neurobiol. 2004, 61: 149-160. 10.1002/neu.20080.PubMed Cravatt BF, Lichtman AH: The endogenous cannabinoid system and its role in nociceptive behavior. J Neurobiol. 2004, 61: 149-160. 10.1002/neu.20080.PubMed
51.
Zurück zum Zitat Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH: Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolyse. Proc Natl Acad Sci USA. 2001, 98: 9371-9376. 10.1073/pnas.161191698.PubMedCentralPubMed Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH: Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolyse. Proc Natl Acad Sci USA. 2001, 98: 9371-9376. 10.1073/pnas.161191698.PubMedCentralPubMed
52.
Zurück zum Zitat Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BJ: Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther. 2004, 311: 441-448. 10.1124/jpet.104.069401.PubMed Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BJ: Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther. 2004, 311: 441-448. 10.1124/jpet.104.069401.PubMed
53.
Zurück zum Zitat Chang L, Luo L, Palmer JA, Sutton S, Wilson SJ, Barbier AJ, Breitenbucher JG, Chaplan SR, Webb M: Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. Br J Pharmacol. 2006, 148: 102-113. 10.1038/sj.bjp.0706699.PubMedCentralPubMed Chang L, Luo L, Palmer JA, Sutton S, Wilson SJ, Barbier AJ, Breitenbucher JG, Chaplan SR, Webb M: Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. Br J Pharmacol. 2006, 148: 102-113. 10.1038/sj.bjp.0706699.PubMedCentralPubMed
54.
Zurück zum Zitat Cichewicz DL, McCarthy EA: Antinociceptive synergy between D9 tetrahydrocannabinol and opioids after oral administration. J Pharmacol Exp Ther. 2003, 304: 1010-1015. 10.1124/jpet.102.045575.PubMed Cichewicz DL, McCarthy EA: Antinociceptive synergy between D9 tetrahydrocannabinol and opioids after oral administration. J Pharmacol Exp Ther. 2003, 304: 1010-1015. 10.1124/jpet.102.045575.PubMed
55.
Zurück zum Zitat England S, Bevan S, Dougherty RJ: PGE2 modulate the tetrodotoxin-resistant sodium current in neonatal dorsal root ganglion neurons via the cyclic AMP-protein kinase A cascade. J Physiol. 1996, 495: 429-440.PubMedCentralPubMed England S, Bevan S, Dougherty RJ: PGE2 modulate the tetrodotoxin-resistant sodium current in neonatal dorsal root ganglion neurons via the cyclic AMP-protein kinase A cascade. J Physiol. 1996, 495: 429-440.PubMedCentralPubMed
56.
Zurück zum Zitat Gold MS, Levine JD, Correa M: Modulation of TTX-R I Na by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci. 1998, 18: 10345-10355.PubMed Gold MS, Levine JD, Correa M: Modulation of TTX-R I Na by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci. 1998, 18: 10345-10355.PubMed
57.
Zurück zum Zitat Bar K-J, Natura G, Telleria-Diaz A, Tascher P, Vogel R, Vasques E, Schaible H-G, Ebersberger A: Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E9EP1-EP4) receptors in spinal nociceptive processing of input from the normal and inflamed knee joint. J Neurosci. 2004, 24: 642-651. 10.1523/JNEUROSCI.0882-03.2004.PubMed Bar K-J, Natura G, Telleria-Diaz A, Tascher P, Vogel R, Vasques E, Schaible H-G, Ebersberger A: Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E9EP1-EP4) receptors in spinal nociceptive processing of input from the normal and inflamed knee joint. J Neurosci. 2004, 24: 642-651. 10.1523/JNEUROSCI.0882-03.2004.PubMed
58.
Zurück zum Zitat Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC: The acute hyperalgesic action of non-steroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001, 21: 5847-5853.PubMed Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC: The acute hyperalgesic action of non-steroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001, 21: 5847-5853.PubMed
59.
Zurück zum Zitat Harvey RJ, Depner UB, Wassle H, Ahmadi S, Heidl C, Reinold H, Smart TG, Harvey K, Schultz B, Abo-Salem OM, et al: Gly α3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science. 2004, 304: 884-887. 10.1126/science.1094925.PubMed Harvey RJ, Depner UB, Wassle H, Ahmadi S, Heidl C, Reinold H, Smart TG, Harvey K, Schultz B, Abo-Salem OM, et al: Gly α3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science. 2004, 304: 884-887. 10.1126/science.1094925.PubMed
60.
Zurück zum Zitat Chandrasekharan NV, Dai H, Roos KLT, Evanson NK, Tomsik J, Elton TS, Simmons DL: COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci USA. 2002, 99: 13926-13931. 10.1073/pnas.162468699.PubMedCentralPubMed Chandrasekharan NV, Dai H, Roos KLT, Evanson NK, Tomsik J, Elton TS, Simmons DL: COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci USA. 2002, 99: 13926-13931. 10.1073/pnas.162468699.PubMedCentralPubMed
61.
Zurück zum Zitat Mitchell JA, Warner TD: COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs. Nat Rev Drug Discov. 2006, 5: 75-85. 10.1038/nrd1929.PubMed Mitchell JA, Warner TD: COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs. Nat Rev Drug Discov. 2006, 5: 75-85. 10.1038/nrd1929.PubMed
62.
Zurück zum Zitat Jakobsson PJ, Thoen S, Morgenstern R, Samuelsson B: Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA. 1999, 96: 7220-7225. 10.1073/pnas.96.13.7220.PubMedCentralPubMed Jakobsson PJ, Thoen S, Morgenstern R, Samuelsson B: Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA. 1999, 96: 7220-7225. 10.1073/pnas.96.13.7220.PubMedCentralPubMed
63.
Zurück zum Zitat Claveau D, Sirinyan M, Guay J, Gordon R, Chan C-C, Bureau Y, Riendeau D, Mancini JA: Microsomal prostaglandin synnthase-1 is a major terminal synthase that is selectively upregulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-arthritis model. J Immunol. 2003, 170: 4738-4744.PubMed Claveau D, Sirinyan M, Guay J, Gordon R, Chan C-C, Bureau Y, Riendeau D, Mancini JA: Microsomal prostaglandin synnthase-1 is a major terminal synthase that is selectively upregulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-arthritis model. J Immunol. 2003, 170: 4738-4744.PubMed
64.
Zurück zum Zitat Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, et al: Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA. 2003, 100: 9044-9049. 10.1073/pnas.1332766100.PubMedCentralPubMed Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, et al: Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA. 2003, 100: 9044-9049. 10.1073/pnas.1332766100.PubMedCentralPubMed
65.
Zurück zum Zitat Sommer C, Kress M: Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett. 2004, 361: 184-187. 10.1016/j.neulet.2003.12.007.PubMed Sommer C, Kress M: Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett. 2004, 361: 184-187. 10.1016/j.neulet.2003.12.007.PubMed
66.
Zurück zum Zitat Ohtori S, Takahashi K, Moriya H, Myers RR: TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. Spine. 2004, 29: 1082-1088. 10.1097/00007632-200405150-00006.PubMed Ohtori S, Takahashi K, Moriya H, Myers RR: TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. Spine. 2004, 29: 1082-1088. 10.1097/00007632-200405150-00006.PubMed
67.
Zurück zum Zitat Pollock J, McFarlane SM, Connell MC, Zehavi U, Vandenabeele P, MacEwan DJ, Scott RH: TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurons. Neuropharmacology. 2002, 42: 93-106. 10.1016/S0028-3908(01)00163-0.PubMed Pollock J, McFarlane SM, Connell MC, Zehavi U, Vandenabeele P, MacEwan DJ, Scott RH: TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurons. Neuropharmacology. 2002, 42: 93-106. 10.1016/S0028-3908(01)00163-0.PubMed
68.
Zurück zum Zitat Schafers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C: Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004, 185: 160-168. 10.1016/j.expneurol.2003.09.015.PubMed Schafers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C: Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004, 185: 160-168. 10.1016/j.expneurol.2003.09.015.PubMed
69.
Zurück zum Zitat Schafers M, Sorkin LS, Geis C, Shubayev VI: Spinal ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia of rat. Neurosci Lett. 2003, 347: 179-182. 10.1016/S0304-3940(03)00695-5.PubMed Schafers M, Sorkin LS, Geis C, Shubayev VI: Spinal ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia of rat. Neurosci Lett. 2003, 347: 179-182. 10.1016/S0304-3940(03)00695-5.PubMed
70.
Zurück zum Zitat Grunke M, Schulze-Koops H: Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade. Ann Rheum Dis. 2006, 65: 555-556. 10.1136/ard.2006.053272.PubMedCentralPubMed Grunke M, Schulze-Koops H: Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade. Ann Rheum Dis. 2006, 65: 555-556. 10.1136/ard.2006.053272.PubMedCentralPubMed
71.
Zurück zum Zitat Watkins LR, Maier S: Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002, 82: 981-1011.PubMed Watkins LR, Maier S: Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 2002, 82: 981-1011.PubMed
72.
Zurück zum Zitat Zhang N, Inan S, Cowan A, Sun R, Wang JM, Rogers TJ, Caterina M, Oppenheim JJ: A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci USA. 2005, 102: 4536-4541. 10.1073/pnas.0406030102.PubMedCentralPubMed Zhang N, Inan S, Cowan A, Sun R, Wang JM, Rogers TJ, Caterina M, Oppenheim JJ: A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci USA. 2005, 102: 4536-4541. 10.1073/pnas.0406030102.PubMedCentralPubMed
73.
Zurück zum Zitat Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ: Chemokines and glycoprotein 120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci. 2001, 21: 5027-5035.PubMed Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ: Chemokines and glycoprotein 120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci. 2001, 21: 5027-5035.PubMed
74.
Zurück zum Zitat Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Scholmerich J, Straub RH: Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis. 2005, 64: 13-20. 10.1136/ard.2003.016154.PubMedCentralPubMed Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Scholmerich J, Straub RH: Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis. 2005, 64: 13-20. 10.1136/ard.2003.016154.PubMedCentralPubMed
75.
Zurück zum Zitat Miller LE, Wiedler C, Falk W, Angele P, Schaumberger J, Scholmerich J, Straub R: Increased prevalence of semaphorin3C, a repellent of sympathetic nerve fibres in synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 2004, 50: 1156-1163. 10.1002/art.20110.PubMed Miller LE, Wiedler C, Falk W, Angele P, Schaumberger J, Scholmerich J, Straub R: Increased prevalence of semaphorin3C, a repellent of sympathetic nerve fibres in synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 2004, 50: 1156-1163. 10.1002/art.20110.PubMed
76.
Zurück zum Zitat Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT: Neuropeptides in experimental and degenerative arthritis. Ann N Y Acad Sci. 2002, 966: 384-399.PubMed Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT: Neuropeptides in experimental and degenerative arthritis. Ann N Y Acad Sci. 2002, 966: 384-399.PubMed
77.
Zurück zum Zitat Zhang JM, LI H, Munir MA: Decreasing sympathetic sprouting in pathological sympathetic ganglia: a new mechanism for treating neuropathic pain using lidocaine. Pain. 2004, 109: 143-149. 10.1016/j.pain.2004.01.033.PubMed Zhang JM, LI H, Munir MA: Decreasing sympathetic sprouting in pathological sympathetic ganglia: a new mechanism for treating neuropathic pain using lidocaine. Pain. 2004, 109: 143-149. 10.1016/j.pain.2004.01.033.PubMed
78.
Zurück zum Zitat Shinder V, Govrin-Lippmann R, Cohen S, Belenky M, Ilin P, Fried K, Wilkinson HA, Devor M: Structural basis of sympathetic-sensory coupling in rat and human dorsal root ganglia following peripheral nerve injury. J Neurocytol. 1999, 28: 743-761. 10.1023/A:1007090105840.PubMed Shinder V, Govrin-Lippmann R, Cohen S, Belenky M, Ilin P, Fried K, Wilkinson HA, Devor M: Structural basis of sympathetic-sensory coupling in rat and human dorsal root ganglia following peripheral nerve injury. J Neurocytol. 1999, 28: 743-761. 10.1023/A:1007090105840.PubMed
79.
Zurück zum Zitat Sato J, Perl ER: Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science. 1991, 251: 1608-1610. 10.1126/science.2011742.PubMed Sato J, Perl ER: Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science. 1991, 251: 1608-1610. 10.1126/science.2011742.PubMed
80.
Zurück zum Zitat Lee DH, Liu X, Kim HT, Chung K, Chung JM: Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in neuropathic Lewis rats. J Neurophysiol. 1999, 81: 2226-2233.PubMed Lee DH, Liu X, Kim HT, Chung K, Chung JM: Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in neuropathic Lewis rats. J Neurophysiol. 1999, 81: 2226-2233.PubMed
81.
Zurück zum Zitat Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, Campbell JN: Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain. 2000, 88: 161-168. 10.1016/S0304-3959(00)00327-4.PubMed Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, Campbell JN: Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain. 2000, 88: 161-168. 10.1016/S0304-3959(00)00327-4.PubMed
82.
Zurück zum Zitat McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN: Excitatory amino acids, TNFα and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol. 2004, 137: 621-627. 10.1111/j.1365-2249.2004.02563.x.PubMedCentralPubMed McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN: Excitatory amino acids, TNFα and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol. 2004, 137: 621-627. 10.1111/j.1365-2249.2004.02563.x.PubMedCentralPubMed
83.
Zurück zum Zitat Neugebauer V: Glutamate receptor ligands. Handb Exp Pharmacol. 2007, 177: 217-249.PubMed Neugebauer V: Glutamate receptor ligands. Handb Exp Pharmacol. 2007, 177: 217-249.PubMed
84.
Zurück zum Zitat Szekely JI, Torok K, Mate G: The role of ionotropic glutamate receptors in nociception with special regard to the AMPA binding sites. Curr Pharm Des. 2002, 8: 887-912. 10.2174/1381612024607126.PubMed Szekely JI, Torok K, Mate G: The role of ionotropic glutamate receptors in nociception with special regard to the AMPA binding sites. Curr Pharm Des. 2002, 8: 887-912. 10.2174/1381612024607126.PubMed
85.
Zurück zum Zitat Merle B, Itzstein C, Delmas PD, Chenu C: NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis. J Cell Biochem. 2003, 90: 424-436. 10.1002/jcb.10625.PubMed Merle B, Itzstein C, Delmas PD, Chenu C: NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis. J Cell Biochem. 2003, 90: 424-436. 10.1002/jcb.10625.PubMed
86.
Zurück zum Zitat Salter DM, Wright MO, Millward-Sadler SJ: NMDA receptor expression and roles in human articular chondrocyte mechanotransduction. Biorheology. 2004, 41: 273-281.PubMed Salter DM, Wright MO, Millward-Sadler SJ: NMDA receptor expression and roles in human articular chondrocyte mechanotransduction. Biorheology. 2004, 41: 273-281.PubMed
87.
Zurück zum Zitat Danysz W, Parsons CG: GlycineB recognition site of NMDA receptors and its antagonists. Amino Acids. 1998, 14: 205-206. 10.1007/BF01345263.PubMed Danysz W, Parsons CG: GlycineB recognition site of NMDA receptors and its antagonists. Amino Acids. 1998, 14: 205-206. 10.1007/BF01345263.PubMed
88.
Zurück zum Zitat Quartaroli M, Fasdelli N, Bettelini L, Maraia G, Corsi M: GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice. Eur J Pharmacol. 2001, 430: 219-227. 10.1016/S0014-2999(01)01278-X.PubMed Quartaroli M, Fasdelli N, Bettelini L, Maraia G, Corsi M: GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice. Eur J Pharmacol. 2001, 430: 219-227. 10.1016/S0014-2999(01)01278-X.PubMed
89.
Zurück zum Zitat Wallace MS, Rowbotham MC, Katz NP, Dworkin RH, Dotson RM, Galer BS, Rauck RL, Backonja MM, Quessy SN, Meisner PD: A randomized, double blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. Neurology. 2002, 59: 1694-1700.PubMed Wallace MS, Rowbotham MC, Katz NP, Dworkin RH, Dotson RM, Galer BS, Rauck RL, Backonja MM, Quessy SN, Meisner PD: A randomized, double blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. Neurology. 2002, 59: 1694-1700.PubMed
90.
Zurück zum Zitat Taniguchi K, Shinjo K, Mizutani M, Shimada K, Ishikawa T, Menniti F, Nagahisa A: Antinociceptive actions of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br J Pharmacol. 1997, 122: 809-812. 10.1038/sj.bjp.0701445.PubMedCentralPubMed Taniguchi K, Shinjo K, Mizutani M, Shimada K, Ishikawa T, Menniti F, Nagahisa A: Antinociceptive actions of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br J Pharmacol. 1997, 122: 809-812. 10.1038/sj.bjp.0701445.PubMedCentralPubMed
91.
Zurück zum Zitat Hudson LJ, Bevan S, McNair K, Gentry C, Fox A, Kuhn R, Winter J: Metabotropic glutamate receptor 5 up-regulation in A-fibers after spinal nerve injury: 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. J Neurosci. 2002, 22: 2660-2668.PubMed Hudson LJ, Bevan S, McNair K, Gentry C, Fox A, Kuhn R, Winter J: Metabotropic glutamate receptor 5 up-regulation in A-fibers after spinal nerve injury: 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. J Neurosci. 2002, 22: 2660-2668.PubMed
92.
Zurück zum Zitat Dogrul A, Ossipov MH, Lai J, Malan TP, Porecca F: Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGluR5) antagonist, in experimental neuropathic pain in rats. Neurosci Lett. 2000, 292: 115-118. 10.1016/S0304-3940(00)01458-0.PubMed Dogrul A, Ossipov MH, Lai J, Malan TP, Porecca F: Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGluR5) antagonist, in experimental neuropathic pain in rats. Neurosci Lett. 2000, 292: 115-118. 10.1016/S0304-3940(00)01458-0.PubMed
93.
Zurück zum Zitat Zhu CZ, Wilson SG, Mikusa JP, Wismer CT, Gauvin DM, Lynch JJ, Wade CL, Decker MW, Honore P: Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur J Pharmacol. 2004, 506: 107-118. 10.1016/j.ejphar.2004.11.005.PubMed Zhu CZ, Wilson SG, Mikusa JP, Wismer CT, Gauvin DM, Lynch JJ, Wade CL, Decker MW, Honore P: Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. Eur J Pharmacol. 2004, 506: 107-118. 10.1016/j.ejphar.2004.11.005.PubMed
94.
Zurück zum Zitat Boxall SJ, Berthele A, Laurie DJ, Sommer B, Zieglgansberger W, Urban L, Tolle TR: Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation. Neuroscience. 1998, 82: 591-602. 10.1016/S0306-4522(97)00246-7.PubMed Boxall SJ, Berthele A, Laurie DJ, Sommer B, Zieglgansberger W, Urban L, Tolle TR: Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation. Neuroscience. 1998, 82: 591-602. 10.1016/S0306-4522(97)00246-7.PubMed
95.
Zurück zum Zitat Chiechio S, Caricasole A, Barletta E, Storto M, Catania MV, Copani A, Vertechy M, Nicolai R, Calvani M, Melchiorri D, Nicoletti F: L-Acetylcarnitine induces analgesia by selectively upregulating mGlu2 metabotropic glutamate receptors. Mol Pharmacol. 2002, 61: 989-996. 10.1124/mol.61.5.989.PubMed Chiechio S, Caricasole A, Barletta E, Storto M, Catania MV, Copani A, Vertechy M, Nicolai R, Calvani M, Melchiorri D, Nicoletti F: L-Acetylcarnitine induces analgesia by selectively upregulating mGlu2 metabotropic glutamate receptors. Mol Pharmacol. 2002, 61: 989-996. 10.1124/mol.61.5.989.PubMed
96.
Zurück zum Zitat Vellani V, Mappleback S, Moriondo A, Davis JB, McNaughton PA: Protein kinase C activation gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol. 2001, 534: 813-825. 10.1111/j.1469-7793.2001.00813.x.PubMedCentralPubMed Vellani V, Mappleback S, Moriondo A, Davis JB, McNaughton PA: Protein kinase C activation gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol. 2001, 534: 813-825. 10.1111/j.1469-7793.2001.00813.x.PubMedCentralPubMed
97.
Zurück zum Zitat Szallasi A, Blumberg PM: Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev. 1999, 51: 159-212.PubMed Szallasi A, Blumberg PM: Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev. 1999, 51: 159-212.PubMed
98.
Zurück zum Zitat Cantillon M, Vause E, Sykes D, Moon A, Hughes S: Safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee. Journal of Pain. 2005, 6 (3): S39- Cantillon M, Vause E, Sykes D, Moon A, Hughes S: Safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee. Journal of Pain. 2005, 6 (3): S39-
99.
Zurück zum Zitat Garcia-Martiez C, Humet M, Planells-Casas R, Gomis A, Capri M, Viaa F, de la Pena E, Sachez-Baez F, Carbonell T, de Felipe C, et al: Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci USA. 2002, 99: 2374-2379. 10.1073/pnas.022285899. Garcia-Martiez C, Humet M, Planells-Casas R, Gomis A, Capri M, Viaa F, de la Pena E, Sachez-Baez F, Carbonell T, de Felipe C, et al: Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci USA. 2002, 99: 2374-2379. 10.1073/pnas.022285899.
100.
Zurück zum Zitat Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, et al: AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005, 313: 474-484. 10.1124/jpet.104.079855.PubMed Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, et al: AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005, 313: 474-484. 10.1124/jpet.104.079855.PubMed
101.
Zurück zum Zitat Chizh B, Napolitano A, O'Donnell M, Wang J, Brooke A, Lai R, Aylott M, Bullman J, Gray E, Williams P, Appleby J: The TRPV1 antagonist SB705498 attenuates TRPV1 receptor mediated activity and inhibits inflammatory hyperalgesia in humans: Results from a Phase 1 study. Journal of Pain. 2006, 7 (4): S42- Chizh B, Napolitano A, O'Donnell M, Wang J, Brooke A, Lai R, Aylott M, Bullman J, Gray E, Williams P, Appleby J: The TRPV1 antagonist SB705498 attenuates TRPV1 receptor mediated activity and inhibits inflammatory hyperalgesia in humans: Results from a Phase 1 study. Journal of Pain. 2006, 7 (4): S42-
102.
Zurück zum Zitat Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Pataapouian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004, 41: 849-853. 10.1016/S0896-6273(04)00150-3.PubMed Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Pataapouian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004, 41: 849-853. 10.1016/S0896-6273(04)00150-3.PubMed
103.
Zurück zum Zitat Bland-Ward PA, Humphrey PP: P2x receptor mediated ATP-induced primary nociceptive neurone activation. J Auton Nerv Syst. 2000, 81: 146-151. 10.1016/S0165-1838(00)00122-3.PubMed Bland-Ward PA, Humphrey PP: P2x receptor mediated ATP-induced primary nociceptive neurone activation. J Auton Nerv Syst. 2000, 81: 146-151. 10.1016/S0165-1838(00)00122-3.PubMed
104.
Zurück zum Zitat Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K: Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain. 2002, 99: 11-19. 10.1016/S0304-3959(02)00032-5.PubMed Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K: Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain. 2002, 99: 11-19. 10.1016/S0304-3959(02)00032-5.PubMed
105.
Zurück zum Zitat Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, van Biesen T, Cartmell J, Bianchi B, et al: A-317491, a novel potent and selective non nucleotide antagonist of P2X(3) and P2X(2/3) receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA. 2002, 99: 17179-17184. 10.1073/pnas.252537299.PubMedCentralPubMed Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, van Biesen T, Cartmell J, Bianchi B, et al: A-317491, a novel potent and selective non nucleotide antagonist of P2X(3) and P2X(2/3) receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci USA. 2002, 99: 17179-17184. 10.1073/pnas.252537299.PubMedCentralPubMed
106.
Zurück zum Zitat Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003, 424: 778-783. 10.1038/nature01786.PubMed Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003, 424: 778-783. 10.1038/nature01786.PubMed
107.
Zurück zum Zitat Deuchars SA, Atkinson L, Brooke RE, Musa H, Milligan CJ, Batten TFC, Buckley NJ, Parson SH, Deuchars J: Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J Neurosci. 2001, 21: 7143-7152.PubMed Deuchars SA, Atkinson L, Brooke RE, Musa H, Milligan CJ, Batten TFC, Buckley NJ, Parson SH, Deuchars J: Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J Neurosci. 2001, 21: 7143-7152.PubMed
108.
Zurück zum Zitat Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, et al: Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005, 114: 386-396. 10.1016/j.pain.2005.01.002.PubMed Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, et al: Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005, 114: 386-396. 10.1016/j.pain.2005.01.002.PubMed
109.
Zurück zum Zitat Chaplan SR, Guo H-Q, Lee DH, Luo L, Liu C, Kuei C, Velumian AAL, Butler MP, Brown SM, Dubin AE: Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci. 2003, 23: 1169-1178.PubMed Chaplan SR, Guo H-Q, Lee DH, Luo L, Liu C, Kuei C, Velumian AAL, Butler MP, Brown SM, Dubin AE: Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci. 2003, 23: 1169-1178.PubMed
110.
Zurück zum Zitat Yao H, Donnelly DF, Ma C, LaMotte RH: Upregulation of the hyperpolarization activation cation current after chronic compression of the dorsal root ganglion. J Neurosci. 2003, 23: 2069-2074.PubMed Yao H, Donnelly DF, Ma C, LaMotte RH: Upregulation of the hyperpolarization activation cation current after chronic compression of the dorsal root ganglion. J Neurosci. 2003, 23: 2069-2074.PubMed
111.
Zurück zum Zitat Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter KC, Harris AL, Koukourakis MI: Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2003, 5: R193-201. 10.1186/ar756.PubMedCentralPubMed Giatromanolaki A, Sivridis E, Maltezos E, Athanassou N, Papazoglou D, Gatter KC, Harris AL, Koukourakis MI: Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2003, 5: R193-201. 10.1186/ar756.PubMedCentralPubMed
112.
Zurück zum Zitat Leffler A, Monter B, Koltzenburg M: The role of the capsaicin receptor TRPV1 and acid sensing ion channels (ASICs) in proton sensitivity of subpopulation of primary nociceptive neurons in rats and mice. Neuroscience. 2006, 139: 699-709. 10.1016/j.neuroscience.2005.12.020.PubMed Leffler A, Monter B, Koltzenburg M: The role of the capsaicin receptor TRPV1 and acid sensing ion channels (ASICs) in proton sensitivity of subpopulation of primary nociceptive neurons in rats and mice. Neuroscience. 2006, 139: 699-709. 10.1016/j.neuroscience.2005.12.020.PubMed
113.
Zurück zum Zitat Dube GR, Lehto SG, Breese NM, Baker SJ, Wang X, Matulenko MA, Honore P, Stewart AO, Moreland RB, Brioni JD: Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain. 2005, 117: 88-96. 10.1016/j.pain.2005.05.021.PubMed Dube GR, Lehto SG, Breese NM, Baker SJ, Wang X, Matulenko MA, Honore P, Stewart AO, Moreland RB, Brioni JD: Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain. 2005, 117: 88-96. 10.1016/j.pain.2005.05.021.PubMed
114.
Zurück zum Zitat Matzner O, Devor M: Hyperexcitability at sites of nerve injury depends on voltage sensitive sodium channels. J Neurophysiol. 1994, 72: 349-359.PubMed Matzner O, Devor M: Hyperexcitability at sites of nerve injury depends on voltage sensitive sodium channels. J Neurophysiol. 1994, 72: 349-359.PubMed
115.
Zurück zum Zitat Eglen RM, Hunter JC, Dray A: Ions in the fire: recent ion-channel research and approaches to pain therapy. Trends Pharmacol Sci. 1999, 8: 337-342. 10.1016/S0165-6147(99)01372-3. Eglen RM, Hunter JC, Dray A: Ions in the fire: recent ion-channel research and approaches to pain therapy. Trends Pharmacol Sci. 1999, 8: 337-342. 10.1016/S0165-6147(99)01372-3.
116.
Zurück zum Zitat Devor M: Sodium channels and mechanisms of neuropathic pain. Pain. 2005, 7 (Suppl 1): S3-S12. Devor M: Sodium channels and mechanisms of neuropathic pain. Pain. 2005, 7 (Suppl 1): S3-S12.
117.
Zurück zum Zitat Waxman SG, Dib-Hajj S: Erythermalgia: molecular basis for an inherited pain syndrome. Trends Mol Med. 2005, 11: 555-562. 10.1016/j.molmed.2005.10.004.PubMed Waxman SG, Dib-Hajj S: Erythermalgia: molecular basis for an inherited pain syndrome. Trends Mol Med. 2005, 11: 555-562. 10.1016/j.molmed.2005.10.004.PubMed
118.
Zurück zum Zitat Gould HJ, England JD, Soignier RD, Nolan P, Minor LD, Liu ZP, Levinson SR, Paul D: Ibuprofen blocks changes in NaV1.7 and 1.8 sodium currents associated with complete Freunds adjuvant induced inflammation in rat. Pain. 2004, 5: 270-280. 10.1016/j.jpain.2004.04.005. Gould HJ, England JD, Soignier RD, Nolan P, Minor LD, Liu ZP, Levinson SR, Paul D: Ibuprofen blocks changes in NaV1.7 and 1.8 sodium currents associated with complete Freunds adjuvant induced inflammation in rat. Pain. 2004, 5: 270-280. 10.1016/j.jpain.2004.04.005.
119.
Zurück zum Zitat Araujo MC, Sinnott CJ, Strichartz GR: Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain. 2003, 103: 21-29. 10.1016/S0304-3959(02)00350-0.PubMed Araujo MC, Sinnott CJ, Strichartz GR: Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain. 2003, 103: 21-29. 10.1016/S0304-3959(02)00350-0.PubMed
120.
Zurück zum Zitat Kastrup J, Petersen P, Dejgard A, Angelo FR: Intravenous lidocaine infusion: a new treatment of chronic painful diabetic neuropathy. Pain. 1987, 28: 69-75. 10.1016/0304-3959(87)91061-X.PubMed Kastrup J, Petersen P, Dejgard A, Angelo FR: Intravenous lidocaine infusion: a new treatment of chronic painful diabetic neuropathy. Pain. 1987, 28: 69-75. 10.1016/0304-3959(87)91061-X.PubMed
121.
Zurück zum Zitat Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Chao MV, Wood JN: Annexin II light chain regulates sensory neurone-specific sodium channel expression. Nature. 2002, 417: 653-656. 10.1038/nature00781.PubMed Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Chao MV, Wood JN: Annexin II light chain regulates sensory neurone-specific sodium channel expression. Nature. 2002, 417: 653-656. 10.1038/nature00781.PubMed
122.
Zurück zum Zitat Rush AM, Craner MJ, Kageyama T, Dib-Haj SD, Waxman SG: Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005, 22: 39-49. 10.1111/j.1460-9568.2005.04186.x.PubMed Rush AM, Craner MJ, Kageyama T, Dib-Haj SD, Waxman SG: Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005, 22: 39-49. 10.1111/j.1460-9568.2005.04186.x.PubMed
123.
Zurück zum Zitat Yaksh TL: Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006, 7 (1 Suppl 1): S13-S30. 10.1016/j.jpain.2005.09.007.PubMed Yaksh TL: Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006, 7 (1 Suppl 1): S13-S30. 10.1016/j.jpain.2005.09.007.PubMed
124.
Zurück zum Zitat Altier C, Khosravani H, Evans RM, Hameed S, Peloquin JB, Vartian BA, Chen L, Beedle AM, Ferguson SS, Mezghrani A, et al: ORL-1 receptor mediated internalization of N-type calcium channels. Nat Neurosci. 2005, 9: 31-40. 10.1038/nn1605.PubMed Altier C, Khosravani H, Evans RM, Hameed S, Peloquin JB, Vartian BA, Chen L, Beedle AM, Ferguson SS, Mezghrani A, et al: ORL-1 receptor mediated internalization of N-type calcium channels. Nat Neurosci. 2005, 9: 31-40. 10.1038/nn1605.PubMed
125.
Zurück zum Zitat Kim C, Jun K, Lee T, Kim SS, McEnery MW, Chin H, Kim HL, Park JM, Kim DK, Jung SJ, Kim J, Shin HS: Altered nociceptive response in mice deficient in the α(1B) subunit of the voltage-dependent calcium channel. Mol Cell Neurosci. 2001, 18: 235-245. 10.1006/mcne.2001.1013.PubMed Kim C, Jun K, Lee T, Kim SS, McEnery MW, Chin H, Kim HL, Park JM, Kim DK, Jung SJ, Kim J, Shin HS: Altered nociceptive response in mice deficient in the α(1B) subunit of the voltage-dependent calcium channel. Mol Cell Neurosci. 2001, 18: 235-245. 10.1006/mcne.2001.1013.PubMed
126.
Zurück zum Zitat Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T: Suppression of inflammation and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001, 20: 2349-2356. 10.1093/emboj/20.10.2349.PubMedCentralPubMed Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T: Suppression of inflammation and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001, 20: 2349-2356. 10.1093/emboj/20.10.2349.PubMedCentralPubMed
127.
Zurück zum Zitat Xiao WH, Bennett GJ: Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J Pharmacol Exp Ther. 1995, 274: 666-672.PubMed Xiao WH, Bennett GJ: Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J Pharmacol Exp Ther. 1995, 274: 666-672.PubMed
128.
Zurück zum Zitat Snutch TP: Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx. 2005, 2: 662-670. 10.1602/neurorx.2.4.662.PubMedCentralPubMed Snutch TP: Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx. 2005, 2: 662-670. 10.1602/neurorx.2.4.662.PubMedCentralPubMed
129.
Zurück zum Zitat Ikeda H, Heinke B, Ruscheweyh R, Sandkuhler J: Synaptic plasticity in spinal lamina 1 projection neurons that mediate hyperalgesia. Science. 2003, 299: 1237-1240. 10.1126/science.1080659.PubMed Ikeda H, Heinke B, Ruscheweyh R, Sandkuhler J: Synaptic plasticity in spinal lamina 1 projection neurons that mediate hyperalgesia. Science. 2003, 299: 1237-1240. 10.1126/science.1080659.PubMed
130.
Zurück zum Zitat Matthews EA, Dickenson AH: Effects of spinally delivered N-and P-type voltage dependent calacium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Eur J Pharmacol. 2001, 415: 141-149. 10.1016/S0014-2999(01)00812-3.PubMed Matthews EA, Dickenson AH: Effects of spinally delivered N-and P-type voltage dependent calacium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Eur J Pharmacol. 2001, 415: 141-149. 10.1016/S0014-2999(01)00812-3.PubMed
131.
Zurück zum Zitat Flatters SJ, Bennett GJ: Ethosuximaide reverses paclitaxel and vincristine-induced painful peripheral neuropathy. Pain. 2004, 109: 150-161. 10.1016/j.pain.2004.01.029.PubMed Flatters SJ, Bennett GJ: Ethosuximaide reverses paclitaxel and vincristine-induced painful peripheral neuropathy. Pain. 2004, 109: 150-161. 10.1016/j.pain.2004.01.029.PubMed
132.
Zurück zum Zitat Lu Y, Westlund KN: Gabapentin attenuates nociceptive behaviours in an acute arthritis model in rats. J Pharmacol Exp Ther. 1999, 290: 214-219.PubMed Lu Y, Westlund KN: Gabapentin attenuates nociceptive behaviours in an acute arthritis model in rats. J Pharmacol Exp Ther. 1999, 290: 214-219.PubMed
133.
Zurück zum Zitat Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR: Injury type-specific calcium channel alpha (2) delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther. 2002, 303: 1199-1205. 10.1124/jpet.102.041574.PubMed Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR: Injury type-specific calcium channel alpha (2) delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther. 2002, 303: 1199-1205. 10.1124/jpet.102.041574.PubMed
134.
Zurück zum Zitat Jaffe M, Iacobellis D, Young JP, et al: Post-hoc results show beneficial effects of pre-gabalin in patients with osteoarthritis of the hip. Arthritis Rheum. 2000, 43 (Suppl): S337- Jaffe M, Iacobellis D, Young JP, et al: Post-hoc results show beneficial effects of pre-gabalin in patients with osteoarthritis of the hip. Arthritis Rheum. 2000, 43 (Suppl): S337-
135.
Zurück zum Zitat Sah DWY, Ossipov MH, Porecca F: Neurotrophic factors as novel therapeutics for neuropathic pain. Nat Rev Drug Discov. 2003, 2: 460-472. 10.1038/nrd1107.PubMed Sah DWY, Ossipov MH, Porecca F: Neurotrophic factors as novel therapeutics for neuropathic pain. Nat Rev Drug Discov. 2003, 2: 460-472. 10.1038/nrd1107.PubMed
136.
Zurück zum Zitat Zweifel LS, Kuruvilla R, Ginty DD: Functions and mechanisms of retrograde neurotrophin signaling. Nat Rev Neurosci. 2005, 6: 615-625. 10.1038/nrn1727.PubMed Zweifel LS, Kuruvilla R, Ginty DD: Functions and mechanisms of retrograde neurotrophin signaling. Nat Rev Neurosci. 2005, 6: 615-625. 10.1038/nrn1727.PubMed
137.
Zurück zum Zitat Lu B, Pang PT, Woo NH: The Yin and Yang of neurotrophin action. Nat Rev Neurosci. 2005, 6: 603-614. 10.1038/nrn1726.PubMed Lu B, Pang PT, Woo NH: The Yin and Yang of neurotrophin action. Nat Rev Neurosci. 2005, 6: 603-614. 10.1038/nrn1726.PubMed
138.
Zurück zum Zitat Ro LS, Chen ST, Tang LM, Jacobs JM: Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve. Pain. 1999, 79: 265-274. 10.1016/S0304-3959(98)00164-X.PubMed Ro LS, Chen ST, Tang LM, Jacobs JM: Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve. Pain. 1999, 79: 265-274. 10.1016/S0304-3959(98)00164-X.PubMed
139.
Zurück zum Zitat Theodosiou M, Rush RA, Zhou XF, Hu D, Walker JS, Tracey DJ: Hyperalgesia due to nerve damage: role of nerve growth factor. Pain. 1999, 81: 245-255. 10.1016/S0304-3959(99)00018-4.PubMed Theodosiou M, Rush RA, Zhou XF, Hu D, Walker JS, Tracey DJ: Hyperalgesia due to nerve damage: role of nerve growth factor. Pain. 1999, 81: 245-255. 10.1016/S0304-3959(99)00018-4.PubMed
140.
Zurück zum Zitat Hefti FF, Rosenthal A, Walicka PA, Wyatt S, Vergara G, Shelton DL, Davis AM: Novel class of pain drug based on antagonism of NGF. Trends Pharmacol Sci. 2005, 27: 85-91. 10.1016/j.tips.2005.12.001.PubMed Hefti FF, Rosenthal A, Walicka PA, Wyatt S, Vergara G, Shelton DL, Davis AM: Novel class of pain drug based on antagonism of NGF. Trends Pharmacol Sci. 2005, 27: 85-91. 10.1016/j.tips.2005.12.001.PubMed
141.
Zurück zum Zitat Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ: P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron. 2002, 36: 57-68. 10.1016/S0896-6273(02)00908-X.PubMed Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ: P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron. 2002, 36: 57-68. 10.1016/S0896-6273(02)00908-X.PubMed
142.
Zurück zum Zitat Fjell J, Cummings TR, Fried K, Black JA, Waxman SG: In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons. J Neurophysiol. 1999, 81: 803-810.PubMed Fjell J, Cummings TR, Fried K, Black JA, Waxman SG: In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons. J Neurophysiol. 1999, 81: 803-810.PubMed
143.
Zurück zum Zitat Mamet J, Lazdunski M, Voilley N: How nerve growth factor drives physiological and inflammatory expression of acid-sensing ion channels 3 in sensory neurons. J Biol Chem. 2003, 278: 48907-48913. 10.1074/jbc.M309468200.PubMed Mamet J, Lazdunski M, Voilley N: How nerve growth factor drives physiological and inflammatory expression of acid-sensing ion channels 3 in sensory neurons. J Biol Chem. 2003, 278: 48907-48913. 10.1074/jbc.M309468200.PubMed
144.
Zurück zum Zitat Petersen M, Segond von Banchet G, Heppelmann B, Koltzenburg M: Nerve growth factor regulates the expression of bradykinin binding sites on adult sensory neurons via the neurotrophin receptor p75. Neuroscience. 1998, 83: 161-168. 10.1016/S0306-4522(97)00374-6.PubMed Petersen M, Segond von Banchet G, Heppelmann B, Koltzenburg M: Nerve growth factor regulates the expression of bradykinin binding sites on adult sensory neurons via the neurotrophin receptor p75. Neuroscience. 1998, 83: 161-168. 10.1016/S0306-4522(97)00374-6.PubMed
145.
Zurück zum Zitat Ramer MS, Bradbury EJ, McMahon SB: Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem. 2001, 77: 864-875. 10.1046/j.1471-4159.2001.00288.x.PubMed Ramer MS, Bradbury EJ, McMahon SB: Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem. 2001, 77: 864-875. 10.1046/j.1471-4159.2001.00288.x.PubMed
146.
Zurück zum Zitat Oddiah D, Anand P, McMahon SB, Rattray M: Rapid increase of NGF, BDNF and NT3 mRNAs in inflamed bladder. NeuroReport. 1998, 9: 1455-1458. 10.1097/00001756-199805110-00038.PubMed Oddiah D, Anand P, McMahon SB, Rattray M: Rapid increase of NGF, BDNF and NT3 mRNAs in inflamed bladder. NeuroReport. 1998, 9: 1455-1458. 10.1097/00001756-199805110-00038.PubMed
147.
Zurück zum Zitat Miller LJ, Fischer KA, Goralnick SJ, Litt M, Burleson JA, Albertsen P, Kreutzer DL: Nerve growth factor and chronic prostatis/chronic pelvic pain syndrome. Urology. 2002, 59: 603-608. 10.1016/S0090-4295(01)01597-7.PubMed Miller LJ, Fischer KA, Goralnick SJ, Litt M, Burleson JA, Albertsen P, Kreutzer DL: Nerve growth factor and chronic prostatis/chronic pelvic pain syndrome. Urology. 2002, 59: 603-608. 10.1016/S0090-4295(01)01597-7.PubMed
148.
Zurück zum Zitat Aloe L, Tuveri MA, Carcassi U, Levi-Montalcini R: Nerve growth factor in the synovial fluid of patients with chronic arthritis. Arthritis Rheum. 1992, 35: 351-355. 10.1002/art.1780350315.PubMed Aloe L, Tuveri MA, Carcassi U, Levi-Montalcini R: Nerve growth factor in the synovial fluid of patients with chronic arthritis. Arthritis Rheum. 1992, 35: 351-355. 10.1002/art.1780350315.PubMed
149.
Zurück zum Zitat Halliday DA, Zettler C, Rush RA, Scicchitano R, McNeil JD: Elevated growth factor levels in the synovial fluid of patients with inflammatory joint disease. Neurochem Res. 1998, 23: 919-922. 10.1023/A:1022475432077.PubMed Halliday DA, Zettler C, Rush RA, Scicchitano R, McNeil JD: Elevated growth factor levels in the synovial fluid of patients with inflammatory joint disease. Neurochem Res. 1998, 23: 919-922. 10.1023/A:1022475432077.PubMed
150.
Zurück zum Zitat Sarchielli P, Alberti A, Floridi A, Gallai V: Levels of nerve growth factor in cerebrospinal fluid of chronic headache patients. Neurology. 2001, 57: 132-134.PubMed Sarchielli P, Alberti A, Floridi A, Gallai V: Levels of nerve growth factor in cerebrospinal fluid of chronic headache patients. Neurology. 2001, 57: 132-134.PubMed
151.
Zurück zum Zitat Andreev N, Dimitrieva N, Kolzenburg M, McMahon SB: Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. Pain. 1995, 63: 109-115. 10.1016/0304-3959(95)00024-M.PubMed Andreev N, Dimitrieva N, Kolzenburg M, McMahon SB: Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. Pain. 1995, 63: 109-115. 10.1016/0304-3959(95)00024-M.PubMed
152.
Zurück zum Zitat Apfel SC: Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?. Int Rev Neurobiol. 2002, 50: 393-413.PubMed Apfel SC: Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?. Int Rev Neurobiol. 2002, 50: 393-413.PubMed
153.
Zurück zum Zitat Sah DWY, Ossipov MH, Porecca F: Neurotrophic factors as novel therapeutics for neuropathic pain. Nat Rev Drug Discov. 2003, 2: 460-472. 10.1038/nrd1107.PubMed Sah DWY, Ossipov MH, Porecca F: Neurotrophic factors as novel therapeutics for neuropathic pain. Nat Rev Drug Discov. 2003, 2: 460-472. 10.1038/nrd1107.PubMed
154.
Zurück zum Zitat Owolabi JB, Rizkalla G, Tehim A, Ross GM, Riopelle RJ, Kamboj R, Ossipov M, Bianm D, Wegert S, Porreca F, Lee DK: Characterization of antiallodynic actions ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999, 289: 1271-1276.PubMed Owolabi JB, Rizkalla G, Tehim A, Ross GM, Riopelle RJ, Kamboj R, Ossipov M, Bianm D, Wegert S, Porreca F, Lee DK: Characterization of antiallodynic actions ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999, 289: 1271-1276.PubMed
155.
Zurück zum Zitat Colquhoun A, Lawrance GM, Shamovsky IL, Riopelle RJ, Ross GM: Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-benzoylamino)-4,9-dihydro-4methyl-8-oxo-pyrazolo-[5,1-b]-quinazoline-2-carboxylic acid] suggest altered NGF-p75NTR interactions in the presence of trkA. J Pharmacol Exp Ther. 2004, 310: 505-511. 10.1124/jpet.104.066225.PubMed Colquhoun A, Lawrance GM, Shamovsky IL, Riopelle RJ, Ross GM: Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-benzoylamino)-4,9-dihydro-4methyl-8-oxo-pyrazolo-[5,1-b]-quinazoline-2-carboxylic acid] suggest altered NGF-p75NTR interactions in the presence of trkA. J Pharmacol Exp Ther. 2004, 310: 505-511. 10.1124/jpet.104.066225.PubMed
156.
Zurück zum Zitat Lane N, Webster L, Shiaoping Lu, Gray M, Hefti F, Walicke P: RN624 (anti-NGF) improves pain and function in subjects with moderate knee osteoarthritis: a phase i study. Arthritis Rheum. 2005, 52 (Suppl): S461-10.1002/art.20791. Lane N, Webster L, Shiaoping Lu, Gray M, Hefti F, Walicke P: RN624 (anti-NGF) improves pain and function in subjects with moderate knee osteoarthritis: a phase i study. Arthritis Rheum. 2005, 52 (Suppl): S461-10.1002/art.20791.
157.
Zurück zum Zitat Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005, 438: 1017-1021. 10.1038/nature04223.PubMed Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005, 438: 1017-1021. 10.1038/nature04223.PubMed
158.
Zurück zum Zitat Kerr BJ, Bradbury EJ, Bennett DL, Trivedi PM, Dassan P, French J, Shelton DB, McMahon SB, Thompson SW: Brain derived neurotrophic factor modulates nociceptive sensory neurone input and NMDA-evoked responses in the rat spinal cord. J Neurosci. 1999, 19: 5138-5148.PubMed Kerr BJ, Bradbury EJ, Bennett DL, Trivedi PM, Dassan P, French J, Shelton DB, McMahon SB, Thompson SW: Brain derived neurotrophic factor modulates nociceptive sensory neurone input and NMDA-evoked responses in the rat spinal cord. J Neurosci. 1999, 19: 5138-5148.PubMed
159.
Zurück zum Zitat Deng YS, Zhong JH, Zhou XF: Effects of endogenous neurotrophin on sympathetic sprouting in the dorsal root ganglia and allodynia following spinal nerve injury. Exp Neurol. 2000, 164: 344-350. 10.1006/exnr.2000.7432.PubMed Deng YS, Zhong JH, Zhou XF: Effects of endogenous neurotrophin on sympathetic sprouting in the dorsal root ganglia and allodynia following spinal nerve injury. Exp Neurol. 2000, 164: 344-350. 10.1006/exnr.2000.7432.PubMed
160.
Zurück zum Zitat Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER, Lozano AM, Penn RD, Simpson RK, Stacy M, Wooten GF: ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology. 2003, 60: 69-73.PubMed Nutt JG, Burchiel KJ, Comella CL, Jankovic J, Lang AE, Laws ER, Lozano AM, Penn RD, Simpson RK, Stacy M, Wooten GF: ICV GDNF Study Group. Implanted intracerebroventricular. Glial cell line-derived neurotrophic factor. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology. 2003, 60: 69-73.PubMed
161.
Zurück zum Zitat Welch MJ, Purkiss JR, Foster KA: Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins. Toxicon. 2000, 38: 245-258. 10.1016/S0041-0101(99)00153-1.PubMed Welch MJ, Purkiss JR, Foster KA: Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins. Toxicon. 2000, 38: 245-258. 10.1016/S0041-0101(99)00153-1.PubMed
162.
Zurück zum Zitat Mense S: Neurobiological basis for the use of botulinum toxin in pain therapy. J Neurol. 2004, 251 (Suppl 1): I1-I7. 10.1007/s00415-004-1102-z.PubMed Mense S: Neurobiological basis for the use of botulinum toxin in pain therapy. J Neurol. 2004, 251 (Suppl 1): I1-I7. 10.1007/s00415-004-1102-z.PubMed
163.
Zurück zum Zitat Mahowald ML, Singh JA, Dykstra D: Long term effects of intra-articular botulinum toxin A for refractory joint pain. Neurotox Res. 2006, 9: 179-188.PubMed Mahowald ML, Singh JA, Dykstra D: Long term effects of intra-articular botulinum toxin A for refractory joint pain. Neurotox Res. 2006, 9: 179-188.PubMed
164.
Zurück zum Zitat Apostolidis A, Popat R, Yiangou Y, Cockyne D, Ford ABDW, Davis JB, Dasgupta P, Fowler CJ, Anand P: Decreased sensory receptors P2X (3) and TRPV1 in suburothelial nerve fibers following intradetrusor injection of botulinum toxin for human detrusor overactivity. J Urol. 2005, 174: 977-982. 10.1097/01.ju.0000169481.42259.54.PubMed Apostolidis A, Popat R, Yiangou Y, Cockyne D, Ford ABDW, Davis JB, Dasgupta P, Fowler CJ, Anand P: Decreased sensory receptors P2X (3) and TRPV1 in suburothelial nerve fibers following intradetrusor injection of botulinum toxin for human detrusor overactivity. J Urol. 2005, 174: 977-982. 10.1097/01.ju.0000169481.42259.54.PubMed
165.
Zurück zum Zitat D'Amour FE, Smith DL: A method for determining loss of pain sensation. J Pharmacol Exp Ther. 1941, 72: 74-79. D'Amour FE, Smith DL: A method for determining loss of pain sensation. J Pharmacol Exp Ther. 1941, 72: 74-79.
166.
Zurück zum Zitat Woolfe G, MacDonald AD: The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther. 1944, 80: 300-307. Woolfe G, MacDonald AD: The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther. 1944, 80: 300-307.
167.
Zurück zum Zitat Le Bars D, Gozariu M, Cadden SW: Animal models of nociception. Pharmacol Rev. 2001, 53: 597-652.PubMed Le Bars D, Gozariu M, Cadden SW: Animal models of nociception. Pharmacol Rev. 2001, 53: 597-652.PubMed
168.
Zurück zum Zitat Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, Kazis L, Gale DR: The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001, 134: 541-549.PubMed Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, Kazis L, Gale DR: The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001, 134: 541-549.PubMed
169.
Zurück zum Zitat Hill CL, Gale DG, Chaisson CE, Skinner K, Kazis L, Gale ME, Felson DT: Knee effusions, popliteal cysts and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol. 2001, 28: 1330-1337.PubMed Hill CL, Gale DG, Chaisson CE, Skinner K, Kazis L, Gale ME, Felson DT: Knee effusions, popliteal cysts and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol. 2001, 28: 1330-1337.PubMed
170.
Zurück zum Zitat Wluka AE, Wolfe R, Stuckey R, Cicuttini FM: How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis?. Ann Rheum Dis. 2004, 63: 264-268. 10.1136/ard/2003.007666.PubMedCentralPubMed Wluka AE, Wolfe R, Stuckey R, Cicuttini FM: How does tibial cartilage volume relate to symptoms in subjects with knee osteoarthritis?. Ann Rheum Dis. 2004, 63: 264-268. 10.1136/ard/2003.007666.PubMedCentralPubMed
171.
Zurück zum Zitat Van Der Kraan OM, Vitters EL, van de Putte LBA, van den Berg WB: Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. Am J Pathol. 1989, 135: 1001-1014.PubMedCentralPubMed Van Der Kraan OM, Vitters EL, van de Putte LBA, van den Berg WB: Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. Am J Pathol. 1989, 135: 1001-1014.PubMedCentralPubMed
172.
Zurück zum Zitat Clarke KA, Heitmeyer SA, Smith AG, Taiwo YO: Gait analysis in a rat model of osteoarthritis. Physiol Behav. 1997, 62: 951-954. 10.1016/S0031-9384(97)00022-X.PubMed Clarke KA, Heitmeyer SA, Smith AG, Taiwo YO: Gait analysis in a rat model of osteoarthritis. Physiol Behav. 1997, 62: 951-954. 10.1016/S0031-9384(97)00022-X.PubMed
173.
Zurück zum Zitat Ivanavicius SP, Ball AD, Heapy CG, Westwood FR, Murray F, Read SJ: Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: Increased expression of ATF-3 and pharmacological characterization. Pain. 2007 Ivanavicius SP, Ball AD, Heapy CG, Westwood FR, Murray F, Read SJ: Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: Increased expression of ATF-3 and pharmacological characterization. Pain. 2007
174.
Zurück zum Zitat Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, Schrier DJ, Kilgore KS: Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage. 2003, 11: 821-830. 10.1016/S1063-4584(03)00163-8.PubMed Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, Schrier DJ, Kilgore KS: Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage. 2003, 11: 821-830. 10.1016/S1063-4584(03)00163-8.PubMed
175.
Zurück zum Zitat Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, Pellas T, Kidd B, Bevan S, Winter J: Pain releated behaviour in two model of osteoarthritis in the rat knee. Pain. 2004, 112: 83-93. 10.1016/j.pain.2004.08.004.PubMed Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, Pellas T, Kidd B, Bevan S, Winter J: Pain releated behaviour in two model of osteoarthritis in the rat knee. Pain. 2004, 112: 83-93. 10.1016/j.pain.2004.08.004.PubMed
176.
Zurück zum Zitat Pomonis JDM, Boulet JM, Gottshall SL, Phillips S, Rani S, Bunton T, Walker K: Development and pharmacological characterization of a rat model of osteoarthritis pain. Pain. 2005, 114: 339-346. 10.1016/j.pain.2004.11.008.PubMed Pomonis JDM, Boulet JM, Gottshall SL, Phillips S, Rani S, Bunton T, Walker K: Development and pharmacological characterization of a rat model of osteoarthritis pain. Pain. 2005, 114: 339-346. 10.1016/j.pain.2004.11.008.PubMed
Metadaten
Titel
Arthritis and pain. Future targets to control osteoarthritis pain
verfasst von
Andy Dray
Simon J Read
Publikationsdatum
01.06.2007
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2007
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2178

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